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Amplification of Ki-ras and elevation of MAP kinase activity during mammary tumor progression in C3(1)/SV40 Tag transgenic mice

Autor: F. C. Von Lintig, Gerry R. Boss, Marek Liyanage, C. L. Jorcyk, Min-Ling Liu, Jeffrey E. Green, Thomas Ried, Masa-Aki Shibata

Publikováno v: Oncogene. 17:2403-2411

We have previously documented that transgenic mice expressing SV40 Tag regulated by the rat prostatic steroid-binding protein C3(1) 5'-flanking region display multistage mammary tumorigenesis. To delineate genetic changes associated with mammary tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a8b8311d11dbff3cb58f9a24598064
https://doi.org/10.1038/sj.onc.1202456

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Altered expression of transforming growth factor betas during urethral and bulbourethral gland tumor progression in transgenic mice carrying the androgen-responsive C3(1) 5' flanking region fused to SV40 large T antigen

Autor: Masa-Aki Shibata, S Rulong, N Roche, Deborah E. Devor, J Resau, Jeffrey E. Green, C. L. Jorcyk, Katsuhide Yoshidome, A B Roberts, Jerrold M. Ward

Publikováno v: Carcinogenesis. 19(1)

We demonstrate that targeted expression of SV40 large T antigen (TAg) to the urethral (periurethral) and bulbourethral gland epithelium leads to adenocarcinoma formation in these tissues after 7 months of age, which are extremely rare sites for spont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ce44da0a7f942963cb6d11d56e7882
https://pubmed.ncbi.nlm.nih.gov/9472712

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Genetic alterations in the development of mammary and prostate cancer in the C3(1)/Tag transgenic mouse model

Autor: K, Yoshidome, M A, Shibata, I G, Maroulakou, M L, Liu, C L, Jorcyk, L G, Gold, V N, Welch, J E, Green

Publikováno v: International journal of oncology. 12(2)

We have generated a transgenic mouse model in which female mice develop ductal mammary adenocarcinomas and male mice develop prostatic adenocarcinomas by using a transgene containing the hormone-responsive rat prostatic steroid binding protein 5' fla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57fb63a533d4308339070dc140419739
https://pubmed.ncbi.nlm.nih.gov/9458374

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Reduced p53 dosage associated with mammary tumor metastases in C3(1)/TAG transgenic mice

Autor: I G, Maroulakou, M A, Shibata, C L, Jorcyk, X X, Chen, J E, Green

Publikováno v: Molecular carcinogenesis. 20(2)

Transgenic mice expressing the simian virus 40 large T-antigen (TAG) under the regulatory control of the rat prostatic steroid binding protein C3(1) gene develop mammary carcinomas (in females) and prostate carcinomas (in males). The development of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04dcd36d8fa51fd19441cddec80feab1
https://pubmed.ncbi.nlm.nih.gov/9364206

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Multiple regulatory regions control the expression of Ets-1 in the developing mouse: vascular expression conferred by intron I

Autor: C L, Jorcyk, L J, Garrett, I G, Maroulakou, D K, Watson, J E, Green

Publikováno v: Cellular and molecular biology (Noisy-le-Grand, France). 43(2)

Ets-1, a developmentally-regulated protooncogene, is expressed in multiple tissues during different stages of mouse development and cellular differentiation including high levels in lymphoid organs and endothelium. The putative roles of this DNA-bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c3be1213411c0e763bfff3065417dd4
https://pubmed.ncbi.nlm.nih.gov/9130605

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p53-independent apoptosis during mammary tumor progression in C3(1)/SV40 large T antigen transgenic mice: suppression of apoptosis during the transition from preneoplasia to carcinoma

Autor: M A, Shibata, I G, Maroulakou, C L, Jorcyk, L G, Gold, J M, Ward, J E, Green

Publikováno v: Cancer research. 56(13)

Alterations in apoptosis and associated mechanisms during mammary tumor progression were investigated in transgenic mice expressing the SV40 large T antigen (T(AG)) driven by the rat prostatic steroid-binding protein C3(1) 5'-flanking region. Apoptos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32e7ec95ff1d22efaaa8004a91d85517
https://pubmed.ncbi.nlm.nih.gov/8674054

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The human ETS1 gene: genomic structure, promoter characterization and alternative splicing

Autor: C L, Jorcyk, D K, Watson, G J, Mavrothalassitis, T S, Papas

Publikováno v: Oncogene. 6(4)

Genomic clones encompassing the human ETS1 gene were isolated and utilized to define its molecular organization. This gene consists of eight exons spanning over 60 kb. The 5' end of the human ETS1 gene was subcloned and characterized. S1 nuclease, pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2df63622ec35f75c825101913852c2e
https://pubmed.ncbi.nlm.nih.gov/2030910

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Molecular organization and differential polyadenylation sites of the human ETS2 gene

Autor: D K, Watson, G J, Mavrothalassitis, C L, Jorcyk, F E, Smyth, T S, Papas

Publikováno v: Oncogene. 5(10)

The human ETS2 gene is a member of the ets gene family (ETS1, ETS2, ERG, ELK1 and ELK2) with amino acid similarity to the v-ets oncogene of the avian leukemia virus, E26. The ETS2 gene is composed of 10 exons, nine of which contribute to the open rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4e8a7e2368bfc16a93e4afb537a0b90
https://pubmed.ncbi.nlm.nih.gov/2250910

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