CTLA4-IgG Reverses Asthma Manifestations in a Mild but Not in a More 'Severe' Ongoing Murine Model

Autor: D.T. Deurloo, Antoon J. M. van Oosterhout, Frans P. Nijkamp, C. L. Hofstra, Betty C.A.M. van Esch

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 25:751-760

We investigated whether CTLA4-Ig can reverse established asthma manifestations in a novel murine model of ongoing disease. In BALB/c mice, sensitized to ovalbumin (OVA) without adjuvant, airway inflammation was induced by a first series of OVA aeroso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4349c29475eca34445900402e2c9e98
https://doi.org/10.1165/ajrcmb.25.6.4607

Vβ8+T lymphocytes are essential in the regulation of airway hyperresponsiveness and bronchoalveolar eosinophilia but not in allergen-specific IgE in a murine model of allergic asthma

Autor: A. J. M. Van Oosterhout, I. Van Ark, Huub F. J. Savelkoul, Frans P. Nijkamp, William W. Cruikshank, C. L. Hofstra

Publikováno v: Clinical & Experimental Allergy. 28:1571-1580

Background There is increasing evidence that in allergic asthma the inflammatory process is regulated by T lymphocytes. In BALB/c mice the majority of ovalbumin responsive T lymphocytes express the Vβ8.1+ and Vβ8.2+ T-cell receptor. Objective We an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62555e2275f3cc37816469228d3e7082
https://doi.org/10.1046/j.1365-2222.1998.00387.x

Bronchoconstriction and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice

Autor: A. J. M. Van Oosterhout, Huub F. J. Savelkoul, J. J. De Bie, Frans P. Nijkamp, H. van Loveren, A. Verheyen, C. L. Hofstra, Edith M. Hessel, Johan Garssen

Publikováno v: European Journal of Pharmacology 293 (1995) 4
European Journal of Pharmacology, 293(4), 401-412

To investigate the mechanisms underlying airway hyperresponsiveness a murine model was developed with several important characteristics of human allergic asthma. Mice were intraperitoneally sensitized with ovalbumin and after 4 weeks challenge via an

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https://doi.org/10.1016/0926-6917(95)90061-6

Abstracts of papers and posters

Autor: R. L. Anthonio, A. T. M. Willemsen, T. Visser, A. Waarde, P. Elzinga, A. Weemaes, J. G. Meeder, J. Pruim, G. Visser, P. K. Blanksma, W. Vaalburg, P. G. M. Bloemen, P. A. J. Henricks, L. Bloois, M. C. Tweel, F. P. Nijkamp, D. J. A. Crommelin, G. Storm, A. H. Boer, H. M. I. Winter, C. F. Lerk, J. Boer, H. Meurs, A. E. Bottone, M. Koopal, J. C. Visser, J. Zaagsma, P. Borger, H. F. Kauffman, J. L. J. Vijgen, D. S. Postma, E. Vellenga, Theresa L. Buckley, H. Buikema, W. H. Gilst, D. J. Veldhuisen, B. J. G. L. Smet, E. Scholtens, K. I. Lie, H. Wesseling, P. K. Cheung, F. W. D. Dijkhuis, W. W. Bakker, J. Visser, R. P. Coopes, L. Benthem, J. Leest, A. F. Roffel, R. P. Coppes, L. J. W. Zeilstra, A. Vissink, A. W. T. Konings, M. Dijkstra, G. In't Veld, M. Müller, G. J. Berg, F. Kuipers, R. J. Vonk, P. H. Elsinga, E. J. F. Franssen, W. T. A. Graaf, E. G. E. Vries, G. M. Visser, M. G. Vos, A. H. Braker, T. J. Visser, F. Engels, A. H. Houwelingen, M. J. Velde, R. T. Gansevoort, W. J. Sluiter, M. H. Hemmelder, D. Zeeuw, P. E. Jong, H. P. M. M. Gelissen, R. H. Henning, A. H. Epema, J. Eekeren, P. J. Hennis, A. Hertog, S. S. N. Graaf, S. J. Kellie, H. Bloemhof, I. Johnston, M. Besser, R. W. Chaseling, R. A. Ouvrier, D. R. A. Uqes, A. Haan, H. J. Geerligs, J. P. Huchshorn, G. J. M. Scharenburg, J. Wilschut, M. Haas, C. A. Kluppel, D. K. F. Meijer, F. Moolenaar, Eibert R. Heerdink, Hubert G. Leufkens, Ron M. C. Herings, Bruno H. Ch. Stricker, Albert Bakker, W. F. Heesen, F. W. Beltman, A. J. Smit, J. F. May, B. Meyboom-de Jong, M. Duin, J. Akker, M. F. W. Pas, J. P. Popta, S. A. Nelemans, H. J. Linde, A. Boer, F. Sturmans, E. M. Hessel, A. J. M. Oosterhout, C. L. Hofstra, J. Garssen, H. Loveren, H. F. J. Savelkoul, Y. Hoekstra, E. J. M. Weersink, J. W. Jong, B. Belt-Gritter, Lisa M. Jonkman, Chantal Kemner, Harry S. Koelega, Herman Engeland, Marinus N. Verbaten, M. Kalivianakis, I. Zijlstra, H. J. Verkade, H. Elzinga, F. Stellaard, J. A. A. M. Kamps, P. J. Swart, H. Morselt, G. L. Scherphof, J. L. Kenemans, M. M. Lorist, N. R. Koopen, A. D. Kraneveld, A. Si. Koster, M. E. Kuipers, M. Groenink, H. Huisman, H. Schuitemaker, H. S. Lau, I. J. P. M. Broek, A. Dijk, J. Oostinga, A. J. Porsius, Y. Lin, R. Havinga, R. J. Meijer, Th. W. Mark, G. H. Koëter, A. A. Michels, V. -T. Nguyen, O. Bensaude, H. H. Kampinga, Inge C. M. Mohede, J. M. Antoon, Grietje Molema, Thomas S. Edgington, Philip E. Thorpe, P. Olinga, G. W. Sandker, M. J. H. Slooff, M. T. Merema, G. M. M. Groothuis, G. Hofman, I. Ark, J. J. C. Paulussen, M. J. E. Fischer, N. J. Mol, L. H. M. Janssen, E. Th. J. Peters, G. Th. Werf, F. M. Haaijer-Ruskamp, Yigal M. Pinto, Gerrit Rooks, Jean G. Grandjean, Tjark Ebels, H. Schunkert, Frank A. Redegeld, Johan Garssen, Henk Loveren, Irma M. Rigter, Muck Groningen, Gertjan J. Boks, Jan P. Tollenaere, Keith I. Trollope, Jeremy G. Vinter, Gudarz Sadeghi Hashjin, Gert Folkerts, Peet G. F. Loo, R. E. Santing, C. G. Olymulder, K. Molen, Y. Pasman, Heleen Scheerens, T. J. A. Seppenwoolde-Waasdorp, P. Boer, H. M. J. Engelen, J. H. H. Thijssen, R. A. A. Maes, J. Smit, J. W. Smit, H. Steen, M. H. Steurs, P. F. M. Kuks, J. A. Leusink, Balázs M. Szabó, Harry J. G. M. Crijns, Ans C. P. Wiesfeld, H. Talsma, J. C. H. Borchert, M. J. Steenbergen, W. E. Hennink, K. B. Teeuw, H. Cromheecke, A. Schreudering, B. C. H. Teisman, W. Maselbas, G. T. P. Wolters-Keulemans, R. G. Tieleman, C. D. J. Langen, K. Bel, H. J. G. M. Crijns, J. Grandjean, M. Wijffels, A. H. Klimp, P. F. Meer, M. A. Allessie, H. A. Tissot Patot, B. M. Jongh, Y. S. Tuininga, J. Brouwer, J. Haaksma, A. J. Man in't Veld, F. J. Blomjous, M. H. Vingerhoeds, S. O. Belliot, H. J. Haisma, C. A. Visscher, R. M. Huisman, G. J. Navis, J. F. Vlieger, P. Wijngaard, J. Wilting, D. Heuven-Nolsen, A. A. Voors, B. L. Brussel, H. W. M. Plokker, R. C. A. M. Waardenburg, Prins J. Meijer, C. Vries, N. H. Mulder, P. K. Wierenga, P. Schoen, R. Bron

Publikováno v: Pharmacy World & Science. 16:H3-H21

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https://doi.org/10.1007/bf01883242

Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels

Autor: C L, Hofstra, I, Van Ark, G, Hofman, M, Kool, F P, Nijkamp, A J, Van Oosterhout

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(9)

Allergic asthma is thought to be regulated by Th2 cells, and inhibiting this response is a promising mode of intervention. Many studies have focused on differentiation of Th cells to the Th1 or Th2 subset in vitro. IL-4 is essential for Th2 developme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a85e0f87ebe4a73ff7e03812da9944a4
https://pubmed.ncbi.nlm.nih.gov/9794443