Zobrazeno 1 - 10
of 42
pro vyhledávání: '"C L, Eastham"'
Autor:
C L Eastham, Kevin C. Dellsperger, David G. Harrison, Daniel W. Nuno, Kathryn G. Lamping, M Fujii
Publikováno v:
Circulation Research. 71:120-126
We tested the hypothesis that transmural differences in coronary microvascular pressures may be greater in the setting of hypertension and left ventricular hypertrophy. Epicardial and endocardial microvascular pressures were measured in isolated lido
Publikováno v:
Circulation Research. 69:1146-1151
The purpose of the present study was to test the hypothesis that ATP-sensitive potassium channels mediate autoregulatory vasodilatation of coronary arterioles in vivo. Experiments were performed in 23 open-chest anesthetized dogs. Coronary arterial m
Autor:
James N. Bates, C L Eastham, Kathryn G. Lamping, M A Kurz, Melvin L. Marcus, David G. Harrison
Publikováno v:
Circulation Research. 68:847-855
Nitroglycerin dilates large (greater than or equal to 100 microns) but not small coronary arterial microvessels, and a putative metabolite of nitroglycerin, S-nitroso-L-cysteine, has been shown in vitro to dilate both large and small coronary microve
Publikováno v:
Circulation Research. 68:726-733
Chronic systemic hypertension has been shown to alter the distribution of vascular resistance in many microvascular beds. The purposes of this study were to assess the effects of chronic systemic hypertension on the pressure distribution in the coron
Publikováno v:
The American journal of physiology. 263(3 Pt 2)
Endothelin is a 21-amino acid peptide originally isolated from vascular endothelial cells. In the present study, we examined the effect of topical and intracoronary administration of endothelin-1 on the coronary microcirculation and the effect of inh
Publikováno v:
Microvascular research. 43(3)
The objectives of the present study were first, to determine the coronary microvascular response to vagal stimulation and to compare it to exogenously administered acetylcholine, and second, to determine the microvascular response to larger doses of
Publikováno v:
Journal of cardiovascular pharmacology. 19(5)
Nitroglycerin dilates conduit coronary vessels and only transiently increases flow, however the effects of nitroglycerin in the microcirculation of normal myocardium and during myocardial ischemia have not been assessed. The goal of this investigatio
Autor:
Kevin C. Dellsperger, Tatsuya Komaru, Kathryn G. Lamping, Melvin L. Marcus, C L Eastham, David G. Harrison
Publikováno v:
The American journal of physiology. 261(6 Pt 2)
The purpose of this study was to elucidate the contribution of endothelium-derived relaxing factor (EDRF) derived from arginine to acetylcholine (ACh)-induced coronary arteriolar vasodilatation in vivo. Experiments were performed in 62 open-chest ane
Publikováno v:
The American journal of physiology. 259(3 Pt 2)
The exact microvascular site of coronary vasodilation after coronary artery occlusion has not been clearly established. We sought to determine 1) the microvascular site of recruitable vasodilator reserve after a critical stenosis as assessed by adeno
Autor:
Kevin C. Dellsperger, William M. Chilian, Kathryn G. Lamping, Hiroshi Kanatsuka, C L Eastham, Melvin L. Marcus
Publikováno v:
Circulation. 82(1)
Studies of the coronary circulation have divided vascular resistances into three large components: large vessels, small resistance vessels, and veins. Studies of the epicardial microcirculation in the beating heart using stroboscopic illumination hav