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Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors

Autor: E, Buchdunger, C L, Cioffi, N, Law, D, Stover, S, Ohno-Jones, B J, Druker, N B, Lydon

Publikováno v: The Journal of pharmacology and experimental therapeutics. 295(1)

STI571 (formerly known as CGP 57148B) is a protein-tyrosine kinase inhibitor that is currently in clinical trials for the treatment of chronic myelogenous leukemia. STI571 selectively inhibits the Abl and platelet-derived growth factor (PDGF) recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::17ec00a07e55abd6182a8222333f8c90
https://pubmed.ncbi.nlm.nih.gov/10991971

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Evaluation of biological role of c-Jun N-terminal kinase using an antisense approach

Autor: C L, Cioffi, B P, Monia

Publikováno v: Methods in enzymology. 314

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44abb00d2df39daf96c59c496aaf8983
https://pubmed.ncbi.nlm.nih.gov/10565025

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Selective inhibition of A-Raf and C-Raf mRNA expression by antisense oligodeoxynucleotides in rat vascular smooth muscle cells: role of A-Raf and C-Raf in serum-induced proliferation

Autor: C L, Cioffi, M, Garay, J F, Johnston, K, McGraw, R T, Boggs, D, Hreniuk, B P, Monia

Publikováno v: Molecular pharmacology. 51(3)

Raf kinases, cytoplasmic serine/threonine protein kinases, have been proposed as important participants in mitogen-induced signal transduction. However, the precise role that Raf kinase isozymes play in cellular responses such as proliferation has no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ecccb9ab624115bd51c7560a3da10fd
https://pubmed.ncbi.nlm.nih.gov/9058592

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Characterization of rat lung endothelin receptor subtypes which are coupled to phosphoinositide hydrolysis

Autor: C L, Cioffi, R F, Neale, R H, Jackson, M A, Sills

Publikováno v: The Journal of pharmacology and experimental therapeutics. 262(2)

The ability of endothelin (ET) isopeptides to interact with ET receptor subtypes and stimulate phosphoinositide (PI) hydrolysis was examined in the rat lung. [125I]ET-1 and [125I]ET-3 binding to lung homogenates was saturable with maximal binding cap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91ad1ecb74db52d859fbb3083dff1b2e
https://pubmed.ncbi.nlm.nih.gov/1323655

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Differential sensitivity of phosphoinositide and cyclic GMP responses to short-term regulation by a muscarinic agonist in mouse neuroblastoma cells. Correlation with down-regulation of cell surface receptors

Autor: C L, Cioffi, E E, el-Fakahany

Publikováno v: Biochemical pharmacology. 38(11)

Short-term agonist-induced loss of cell surface muscarinic receptors and desensitization of receptor-mediated cyclic GMP (cGMP) formation and phosphoinositide hydrolysis were examined in mouse neuroblastoma cells (clone N1E-115) in suspension. This t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d81ea5cf9982124f17c2394204adfafd
https://pubmed.ncbi.nlm.nih.gov/2544180

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Short-term desensitization of muscarinic cholinergic receptors in mouse neuroblastoma cells: selective loss of agonist low-affinity and pirenzepine high-affinity binding sites

Autor: C L, Cioffi, E E, el-Fakahany

Publikováno v: The Journal of pharmacology and experimental therapeutics. 238(3)

The effects of brief incubation with carbamylcholine on subsequent binding of [3H]N-methylscopolamine were investigated in mouse neuroblastoma cells (clone N1E-115). This treatment demonstrated that the muscarinic receptors in this neuronal clone can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a5d29e420dd2249285ee61cafe005bd
https://pubmed.ncbi.nlm.nih.gov/3018226

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Pseudo-noncompetitive antagonism of muscarinic receptor-mediated cyclic GMP formation and phosphoinositide hydrolysis by pirenzepine

Autor: E E, el-Fakahany, W, Surichamorn, C L, Amrhein, S, Stenstrom, C L, Cioffi, E, Richelson, M, McKinney

Publikováno v: The Journal of pharmacology and experimental therapeutics. 247(3)

Pirenzepine selectively antagonized muscarinic receptor-mediated cyclic GMP formation in a noncompetitive fashion in mouse neuroblastoma cells (clone N1E-115). These effects of pirenzepine were time- and concentration-dependent and they were also rev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::825284b342c4a68ae4e36bd5733573e8
https://pubmed.ncbi.nlm.nih.gov/2849677

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