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Akademický článek

Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.

Autor: Christopher C Kemball, Stephanie Harkins, Jason K Whitmire, Claudia T Flynn, Ralph Feuer, J Lindsay Whitton

Publikováno v: PLoS Pathogens, Vol 5, Iss 10, p e1000618 (2009)

Many viruses encode proteins whose major function is to evade or disable the host T cell response. Nevertheless, most viruses are readily detected by host T cells, and induce relatively strong T cell responses. Herein, we employ transgenic CD4(+) and

Externí odkaz: https://doaj.org/article/cfa169a10cf548db966c297a81118ccb

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In Vivo Ablation of Type I Interferon Receptor from Cardiomyocytes Delays Coxsackieviral Clearance and Accelerates Myocardial Disease

Autor: Nadine Althof, J. L. Whitton, Claudia T. Flynn, Christopher C. Kemball, Stephanie Harkins, Mehrdad Alirezaei

Publikováno v: Journal of Virology. 88:5087-5099

Acute coxsackievirus B3 (CVB3) infection is one of the most prevalent causes of acute myocarditis, a disease that frequently is identified only after the sudden death of apparently healthy individuals. CVB3 infects cardiomyocytes, but the infection i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967cf5400225687442471ce295f5617d
https://doi.org/10.1128/jvi.00184-14

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Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo

Autor: J. Lindsay Whitton, Claudia T. Flynn, Jason Botten, Martin P. Hosking, Christopher C. Kemball

Publikováno v: Virology. 429:74-90

In vitro studies have shown that enteroviruses employ strategies that may impair the ability of DCs to trigger T cell immunity, but it is unclear how these viruses affect DCs in vivo . Here, we evaluate the effects of wild-type (wt) coxsackievirus B3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2b6ca97ddcc39ce61801217cc9cbc2
https://doi.org/10.1016/j.virol.2012.04.005

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Autophagy, inflammation and neurodegenerative disease

Autor: Mehrdad Alirezaei, Christopher C. Kemball, J. Lindsay Whitton

Publikováno v: European Journal of Neuroscience. 33:197-204

Autophagy is emerging as a central regulator of cellular health and disease and, in the central nervous system (CNS), this homeostatic process appears to influence synaptic growth and plasticity. Herein, we review the evidence that dysregulation of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b9baf455a7563a81c84844e0914ef68
https://doi.org/10.1111/j.1460-9568.2010.07500.x

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Coxsackievirus Infection Induces Autophagy-Like Vesicles and Megaphagosomes in Pancreatic Acinar Cells In Vivo

Autor: William B. Kiosses, Christopher C. Kemball, Malcolm R. Wood, Mehrdad Alirezaei, Stephanie Harkins, Claudia T. Flynn, J. Lindsay Whitton

Publikováno v: Journal of Virology. 84:12110-12124

Autophagy can play an important part in protecting host cells during virus infection, and several viruses have developed strategies by which to evade or even exploit this homeostatic pathway. Tissue culture studies have shown that poliovirus, an ente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d96174602bfa08531febfcddcda0bc
https://doi.org/10.1128/jvi.01417-10

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The Use of Exchange Reactions for the Study of the Nature and Behaviour of Adsorbed Radicals in Catalytic Reactions

Autor: C. Kemball

Publikováno v: Bulletin des Sociétés Chimiques Belges. 67:373-398

Nous decrivons des methodes d'analyse des donnees qui sont obtenues dans des reactions d'echange catalytique. Nous mettons l'accent sur l'importance d'une etude approfondie des quantites relatives des differentes especes isotopiques qui se forment au

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2145dc651160c8a00880c915d61f7967
https://doi.org/10.1002/bscb.19580670707

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Heterogeneity among Viral Antigen-Specific CD4+ T Cells and Their De Novo Recruitment during Persistent Polyomavirus Infection

Autor: Aron E. Lukacher, Eugene Lin, Annette Hadley, Jarad J. Wilson, Christopher C. Kemball, Christopher D. Pack, Amelia R. Hofstetter

Publikováno v: The Journal of Immunology. 185:1692-1700

Virus-specific CD4+ T cells optimize antiviral responses by providing help for antiviral humoral responses and CD8+ T cell differentiation. Although CD4+ T cell responses to viral infections that undergo complete clearance have been studied extensive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::539f5fb20667079337b121dbc295b9dc
https://doi.org/10.4049/jimmunol.0904210

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Enumeration and Functional Evaluation of Virus-Specific CD4 + and CD8 + T Cells in Lymphoid and Peripheral Sites of Coxsackievirus B3 Infection

Autor: Stephanie Harkins, J. Lindsay Whitton, Christopher C. Kemball

Publikováno v: Journal of Virology. 82:4331-4342

Previous studies have suggested that coxsackievirus B (CVB) activates CD8 + T cells in vivo, but the extent of this activation and the antigen specificity of the CD8 + T cells remain uncertain. Furthermore, CVB-induced CD4 + T-cell responses have not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0017334ead6e7d4db7dde94d295f9dd4
https://doi.org/10.1128/jvi.02639-07

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