Výsledky vyhledávání - "C K, Svensson"

Autor: C K, Svensson, E W, Cowen, A A, Gaspari

Publikováno v: Pharmacological reviews. 53(3)

Cutaneous drug reactions are the most frequently occurring adverse reactions to drugs. Among hospitalized patients, the incidence of these reactions ranges from 1 to 3%. The frequency of cutaneous reactions to specific drugs may exceed 10%. These rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b8d362c769a02d12167e64a75ebf5d3
https://pubmed.ncbi.nlm.nih.gov/11546834

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Is hydroxylamine-induced cytotoxicity a valid marker for hypersensitivity reactions to sulfamethoxazole in human immunodeficiency virus-infected individuals?

Autor: T P, Reilly, R D, MacArthur, M J, Farrough, L R, Crane, P M, Woster, C K, Svensson

Publikováno v: The Journal of pharmacology and experimental therapeutics. 291(3)

Hypersensitivity (HS) reactions to sulfonamides and sulfones continue to limit their use in human immunodeficiency virus (HIV)-infected individuals. In vitro cytotoxicity of hydroxylamine metabolites toward peripheral blood mononuclear cells (PBMCs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::52bd787fbaff3acdf031dd3a380d2051
https://pubmed.ncbi.nlm.nih.gov/10565861

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Methemoglobin formation by hydroxylamine metabolites of sulfamethoxazole and dapsone: implications for differences in adverse drug reactions

Autor: T P, Reilly, P M, Woster, C K, Svensson

Publikováno v: The Journal of pharmacology and experimental therapeutics. 288(3)

Differences in the incidence of adverse drug reactions to trimethoprim-sulfamethoxazole and dapsone may result from differences in the formation, disposition, toxicity, and/or detoxification of their hydroxylamine metabolites. In this study, we exami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbaa3ad9546d7c63e5d0ad3f3658c3ae
https://pubmed.ncbi.nlm.nih.gov/10027831

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Longitudinal distribution of arylamine N-acetyltransferases in the intestine of the hamster, mouse, and rat. Evidence for multiplicity of N-acetyltransferases in the intestine

Autor: J A, Ware, C K, Svensson

Publikováno v: Biochemical pharmacology. 52(10)

Experimental and clinical evidence indicates that AcCoA:arylamine N-acetyltransferases (NATs; EC 2.3.1.5) are involved in the bioactivation and inactivation of a wide variety of arylamine, hydrazine, and carcinogenic arylamine xenobiotics. Longitudin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f5ee68715c48bca6962bc3eaa0a8b6e
https://pubmed.ncbi.nlm.nih.gov/8937477

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Arylacetamide deacetylase activity towards monoacetyldapsone. Species comparison, factors that influence activity, and comparison with 2-acetylaminofluorene and p-nitrophenyl acetate hydrolysis

Autor: C V, Preuss, C K, Svensson

Publikováno v: Biochemical pharmacology. 51(12)

The deacetylation of monoacetyldapsone (MADDS) was examined in liver microsomes and cytosol from male Sprague-Dawley rats, Golden Syrian hamsters, and Swiss Albino mice. All three rodent species demonstrated greater MADDS deacetylation activity in li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6684d500fe4c4567a32ac4994009b923
https://pubmed.ncbi.nlm.nih.gov/8687481

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Comparison of acetyl coenzyme A:arylamine N-acetyltransferase activity in the liver, kidney, and intestine of male and female rats from three strains

Autor: J A, Ware, P, Divakaruni, C K, Svensson

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 23(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b29a0abd7fbc739b05f1e761651cd12
https://pubmed.ncbi.nlm.nih.gov/7736928

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Evidence that the biotransformation of dapsone and monoacetyldapsone to their respective hydroxylamine metabolites in rat liver microsomes is mediated by cytochrome P450 2C6/2C11 and 3A1

Autor: C, Vage, C K, Svensson

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 22(4)

The formation of dapsone hydroxylamine (DDS-NOH) and monoacetyldapsone hydroxylamine (MADDS-NOH) was found to be greater in male vs. female rat liver microsomes, suggesting a role for either CYP2C11 or CYP3A2. Preincubation with cimetidine (selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::081f315118b378b1eaa404c5c6338549
https://pubmed.ncbi.nlm.nih.gov/7956732

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Glucocorticoid induction of hepatic acetyl CoA:arylamine N-acetyltransferase activity in the rat

Autor: H, Zaher, C K, Svensson

Publikováno v: Research communications in chemical pathology and pharmacology. 83(2)

N-Acetylation, which is catalyzed by the enzymes N-acetyltransferase (NAT), is an important biotransformation pathway for the elimination of a wide variety of xenobiotics. Based on reports by several investigators that hydrocortisone (HYD) pretreatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79e661ea9653c3b6f28befedb45e4d2b
https://pubmed.ncbi.nlm.nih.gov/8202632

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Effect of solvents on rat liver cytosolic acetyl CoA:arylamine N-acetyltransferase activity in vitro

Autor: C K, Svensson, J A, Ware

Publikováno v: Research communications in chemical pathology and pharmacology. 79(1)

The effect of several solvents on the in vitro activity of rat liver N-acetyltransferase (NAT) isozymes was examined. Dimethylsulfoxide (DMSO), dimethylformamide, dimethyl-acetamide, ethanol, and methanol all reduced NAT II activity in concentrations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ebf99dfb397fd7d0ae2d8615175717e
https://pubmed.ncbi.nlm.nih.gov/8434128

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Effect of H2-receptor antagonists on rat liver cytosolic acetyl CoA:arylamine N-acetyltransferase activity

Autor: C K, Svensson, M, Tomilo

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 20(1)

This investigation examined the effect of cimetidine, famotidine, and ranitidine on rat liver acetyl CoA:arylamine N-acetyltransferase (NAT) activity. Studies were conducted using procainamide and p-aminobenzoic acid as substrate probes for NAT isozy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7deff3f2d8fb907a820064a1fcd3f54
https://pubmed.ncbi.nlm.nih.gov/1371435

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