Zobrazeno 1 - 10
of 291
pro vyhledávání: '"C Justin, Lee"'
Autor:
Jua Lee, Dongtan Yin, Jaekyung Yun, Minsoo Kim, Seong-Wook Kim, Heeyoun Hwang, Ji Eun Park, Boyoung Lee, C. Justin Lee, Hee-Sup Shin, Hyun Joo An
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Gangliosides in the brain play a crucial role in modulating the integrity of vertebrate central nervous system in a region-specific manner. However, to date, a comprehensive structural elucidation of complex intact ganglioside isomers has no
Externí odkaz:
https://doaj.org/article/88ad335f75134e77b2e144cfffd6635a
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease
Autor:
Suhyun Kim, Heejung Chun, Yunha Kim, Yeyun Kim, Uiyeol Park, Jiyeon Chu, Mridula Bhalla, Seung-Hye Choi, Ali Yousefian-Jazi, Sojung Kim, Seung Jae Hyeon, Seungchan Kim, Yeonseo Kim, Yeon Ha Ju, Seung Eun Lee, Hyunbeom Lee, Kyungeun Lee, Soo-Jin Oh, Eun Mi Hwang, Junghee Lee, C. Justin Lee, Hoon Ryu
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-26 (2024)
Abstract Background Astrocytes, one of the most resilient cells in the brain, transform into reactive astrocytes in response to toxic proteins such as amyloid beta (Aβ) in Alzheimer’s disease (AD). However, reactive astrocyte-mediated non-cell aut
Externí odkaz:
https://doaj.org/article/10d1c6d648c04589a8cf3caf530fc135
Autor:
Hyunji Kang, Ah-reum Han, Aihua Zhang, Heejin Jeong, Wuhyun Koh, Jung Moo Lee, Hayeon Lee, Hee Young Jo, Miguel A. Maria-Solano, Mridula Bhalla, Jea Kwon, Woo Suk Roh, Jimin Yang, Hyun Joo An, Sun Choi, Ho Min Kim, C. Justin Lee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Impaired ion channels regulating Golgi pH lead to structural alterations in the Golgi apparatus, such as fragmentation, which is found, along with cognitive impairment, in Alzheimer’s disease. However, the causal relationship between alter
Externí odkaz:
https://doaj.org/article/e0bbc7681bbb40cb81ceba4bc8f53496
Autor:
Ju‐Young Oh, Hyowon Lee, Sun‐Young Jang, Hyunjin Kim, Geunhong Park, Almas Serikov, Jae‐Hwan Jang, Junyeop Kim, Seulkee Yang, Moonsun Sa, Sung Eun Lee, Young‐Eun Han, Tae‐Yeon Hwang, Sharon Jiyoon Jung, Hee Young Kim, Seung Eun Lee, Soo‐Jin Oh, Jeongjin Kim, Jeongyeon Kim, Jongpil Kim, Thomas J. McHugh, C. Justin Lee, Min‐Ho Nam, Hi‐Joon Park
Publikováno v:
Advanced Science, Vol 11, Iss 43, Pp n/a-n/a (2024)
Abstract Despite clinical data stretching over millennia, the neurobiological basis of the effectiveness of acupuncture in treating diseases of the central nervous system has remained elusive. Here, using an established model of acupuncture treatment
Externí odkaz:
https://doaj.org/article/9b8a1679853d479eadeed71cd1449eaf
Autor:
Sunpil Kim, Ye-Ji Kim, Kyoung Hwan Park, Kang Moo Huh, Sun-Woong Kang, C. Justin Lee, Dong Ho Woo
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103320- (2024)
Dopamine-modified hyaluronic acid (DA-HA) has been initially developed as an efficient coating and adhesion material for industrial uses. However, the biological activity and safety of DA-HA in the brain have not been explored yet. Here, we report a
Externí odkaz:
https://doaj.org/article/afbcfa84d5c0400b99cfb01aa2b3f68b
Autor:
Sunpil Kim, Ye-Ji Kim, Kyoung Hwan Park, Kang Moo Huh, Sun-Woong Kang, C. Justin Lee, Dong Ho Woo
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103338- (2024)
Externí odkaz:
https://doaj.org/article/dc141f50486e48f1997c0a8e20ec1975
Autor:
Yeon Ha Ju, Jongwook Cho, Ji-Young Park, Hyunjin Kim, Eun-Bin Hong, Ki Duk Park, C. Justin Lee, Euiheon Chung, Hyoung-Ihl Kim, Min-Ho Nam
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 5, Pp 1193-1205 (2024)
Abstract Neuropathic pain is a debilitating condition caused by the hyperexcitability of spinal dorsal horn neurons and is often characterized by allodynia. Although neuron-independent mechanisms of hyperexcitability have been investigated, the contr
Externí odkaz:
https://doaj.org/article/33cfa45280e4488da082dc4892647469
Autor:
Hyunji Kang, C. Justin Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 4, Pp 850-860 (2024)
Abstract A transmembrane (TMEM) protein with an unknown function is a type of membrane-spanning protein expressed in the plasma membrane or the membranes of intracellular organelles. Recently, several TMEM proteins have been identified as functional
Externí odkaz:
https://doaj.org/article/440d33337286406791288fc867337d91
Autor:
Hyo Jung Shin, In Soo Kim, Seung Gyu Choi, Kayoung Lee, Hyewon Park, Juhee Shin, Dayoung Kim, Jaewon Beom, Yoon Young Yi, Deepak Prasad Gupta, Gyun Jee Song, Won-Suk Chung, C. Justin Lee, Dong Woon Kim
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-22 (2024)
Abstract Age-dependent accumulation of amyloid plaques in patients with sporadic Alzheimer’s disease (AD) is associated with reduced amyloid clearance. Older microglia have a reduced ability to phagocytose amyloid, so phagocytosis of amyloid plaque
Externí odkaz:
https://doaj.org/article/ae781111c5ef4bdeb213eacaa48f1a57
Autor:
Jae Woo Park, Se Eun Park, Wuhyun Koh, Won Hee Jang, Jong Han Choi, Eun Roh, Gil Myoung Kang, Seong Jun Kim, Hyo Sun Lim, Chae Beom Park, So Yeon Jeong, Sang Yun Moon, Chan Hee Lee, Sang Yeob Kim, Hyung Jin Choi, Se Hee Min, C. Justin Lee, Min-Seon Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Nicotinamide adenine dinucleotide (NAD)+ serves as a crucial coenzyme in numerous essential biological reactions, and its cellular availability relies on the activity of the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed salvage pa
Externí odkaz:
https://doaj.org/article/76bd7a81ac16438d856a226c7ca54b56