Zobrazeno 1 - 10
of 22
pro vyhledávání: '"C Jake Harris"'
Publikováno v:
eLife, Vol 12 (2024)
Silencing pathways prevent transposable element (TE) proliferation and help to maintain genome integrity through cell division. Silenced genomic regions can be classified as either euchromatic or heterochromatic, and are targeted by genetically separ
Externí odkaz:
https://doaj.org/article/f173910d7dd743d1b0e8d98004df95ca
Autor:
C Jake Harris, Dylan Husmann, Wanlu Liu, Farid El Kasmi, Haifeng Wang, Ashot Papikian, William A Pastor, Guillaume Moissiard, Ajay A Vashisht, Jeffery L Dangl, James A Wohlschlegel, Steven E Jacobsen
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1005998 (2016)
The MORC family of GHKL ATPases are an enigmatic class of proteins with diverse chromatin related functions. In Arabidopsis, AtMORC1, AtMORC2, and AtMORC6 act together in heterodimeric complexes to mediate transcriptional silencing of methylated DNA
Externí odkaz:
https://doaj.org/article/3caaa8387fac48d093f4b3ea14fca9fe
Autor:
Zhenhui Zhong, Yan Xue, C. Jake Harris, Ming Wang, Zheng Li, Yunqing Ke, Mukun Liu, Jessica Zhou, Yasaman Jami-Alahmadi, Suhua Feng, James A. Wohlschlegel, Steven E. Jacobsen
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background The microrchidia (MORC) proteins are a family of evolutionarily conserved GHKL-type ATPases involved in chromatin compaction and gene silencing. Arabidopsis MORC proteins act in the RNA-directed DNA methylation (RdDM) pathway, whe
Externí odkaz:
https://doaj.org/article/36717267e0554e1a8f34782f596b8a07
Publikováno v:
bioRxiv
Silencing pathways prevent transposable element (TE) proliferation and help to maintain genome integrity through cell division. Silenced genomic regions can be classified as either euchromatic or heterochromatic, and are targeted by genetically separ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfdf7a313e00f797e9de7e541a3a21a1
https://europepmc.org/articles/PMC10197610/
https://europepmc.org/articles/PMC10197610/
Autor:
Laixing Zhang, Steven E. Jacobsen, Jiamu Du, Zhe Wu, C. Jake Harris, Sisi Li, Zhenhui Zhong, Qian Wang, Maojun Yang, Changshi Wang, Zhenlin Yang, Suhua Feng, Jixian Zhai, Yan Xue, Lifan Xiao
Publikováno v:
Science
In eukaryotes, small RNAs (sRNAs) play critical roles in multiple biological processes. Dicer endonucleases are a central part of sRNA biogenesis. In plants, DICER-LIKE PROTEIN 3 (DCL3) produces 24-nucleotide (nt) small interfering RNAs (siRNAs) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800f8507c52b4e79673c29e352f7dd72
https://doi.org/10.1126/science.abl4546
https://doi.org/10.1126/science.abl4546
Autor:
Zhenhui Zhong, Yan Xue, C. Jake Harris, Ming Wang, Zheng Li, Yunqing Ke, Yasaman Jami-Alahmadi, Suhua Feng, James A. Wohlschlegel, Steven E. Jacobsen
BackgroundThe Microrchidia (MORC) proteins are a family of evolutionarily conserved GHKL-type ATPases involved in chromatin compaction and gene silencing. Arabidopsis MORC proteins act in the RNA-directed DNA methylation (RdDM) pathway, where they ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db31b06e6ab7e6e8beb5055bc4343954
https://doi.org/10.1101/2022.11.01.514783
https://doi.org/10.1101/2022.11.01.514783
Autor:
Yasaman Jami-Alahmadi, Gundeep Kaur, C. Jake Harris, Maverick Tan, Sascha H. Duttke, Steven E. Jacobsen, Lucia Ichino, Brandon A. Boone, Sy Redding, Matthew A. Gladstone, Xiaodong Cheng, James A. Wohlschlegel, Luke Strauskulage, Suhua Feng
Publikováno v:
Science
Science (New York, N.Y.), vol 372, iss 6549
Science (New York, N.Y.), vol 372, iss 6549
Methyl readers that repress transcription DNA methylation is a conserved epigenetic mark required for gene silencing in many different organisms. However, how the methyl mark is able to silence genes is still largely unknown. Ichino et al. discovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58cdb94453b009c0dda334ee5e16b22
https://doi.org/10.1126/science.abg6130
https://doi.org/10.1126/science.abg6130
Autor:
Yasaman Jami-Alahmadi, Jihui Sha, Colette L. Picard, Ivy Kwok, Javier Gallego-Bartolomé, C. Jake Harris, Shan Hua, Zhenhui Zhong, Suhua Feng, James A. Wohlschlegel, Jason Gardiner, Steven E. Jacobsen, Ming Wang, Xueshi Cao, Yan Xue
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
The Microrchidia (MORC) family of ATPases are required for transposable element (TE) silencing and heterochromatin condensation in plants and animals, and C. elegans MORC-1 has been shown to topologically entrap and condense DNA. In Arabidopsis thali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ac68b218d8c6710da9b15869912ab2
https://www.repository.cam.ac.uk/handle/1810/327927
https://www.repository.cam.ac.uk/handle/1810/327927
Autor:
William D. Barshop, C. Jake Harris, Qikun Liu, Fei Sun, Michael Carey, James A. Wohlschlegel, Calvin Nguyen, Zhenhui Zhong, Lingyu Zhan, Magdalena E. Potok, Sylvain Bischof, Andrew Q. Rashoff, Jeff A. Long, Suhua Feng, Steven E. Jacobsen, Javier Gallego-Bartolomé, Jixian Zhai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Mediator 12 (MED12) and MED13 are components of the Mediator multi-protein complex, that facilitates the initial steps of gene transcription. Here, in an Arabidopsis mutant screen, we identify MED12 and MED13 as positive gene regulators, both of whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1db81bd4bb567608cbac4b48706f48
https://doi.org/10.1038/s41467-020-16651-5
https://doi.org/10.1038/s41467-020-16651-5
Autor:
C. Jake Harris, Steven E. Jacobsen
Publikováno v:
Cell Research
Heterochromatin Protein 1 (HP1) recognizes histone H3 lysine 9 methylation (H3K9me) through its conserved chromodomain and maintains heterochromatin from fission yeast to mammals. However, in Arabidopsis, Like Heterochromatin Protein 1 (LHP1) recogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b625941e7381d82a15a46581099ff76
https://pubmed.ncbi.nlm.nih.gov/30425322
https://pubmed.ncbi.nlm.nih.gov/30425322