Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.

Autor: Medina-Gomez C; Department of Internal Medicine, Erasmus MC University, Rotterdam, 3015GE, The Netherlands.; The Generation R Study Group, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands., Kemp JP; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, 4102, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK., Dimou NL; Department of Computer Science and Biomedical Informatics of the University of Thessaly, Lamia, GR 35100, Greece.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece., Kreiner E; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark., Chesi A; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Zemel BS; Division of GI, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark., Boer CG; Department of Internal Medicine, Erasmus MC University, Rotterdam, 3015GE, The Netherlands., Ahluwalia TS; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, 2820, Denmark., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark., Evangelou E; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK., Heppe DHM; The Generation R Study Group, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands., Bonewald LF; Departments of Anatomy and Cell Biology and Orthopaedic Surgery, School of Medicine, Indiana University, Indianapolis, IN, 46202, USA., Gorski JP; Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, 64108, USA., Ghanbari M; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands.; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad,, Iran., Demissie S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02131, USA., Duque G; Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St Albans, Victoria, 3021, Australia., Maurano MT; Institute for Systems Genetics, New York University Langone Medical Center, New York, NY, 10016, USA., Kiel DP; Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.; Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.; Broad Institute of MIT and Harvard, Boston, MA, 02115, USA., Hsu YH; Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.; Broad Institute of MIT and Harvard, Boston, MA, 02115, USA.; Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, MA, 02115, USA., C J van der Eerden B; Department of Internal Medicine, Erasmus MC University, Rotterdam, 3015GE, The Netherlands., Ackert-Bicknell C; Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 14642, USA., Reppe S; Department of Medical Biochemistry, Oslo University Hospital, Ullevaal, 0450, Oslo, Norway.; Unger-Vetlesen Institute, Oslo Diakonale Hospital, 0456, Oslo, Norway., Gautvik KM; Unger-Vetlesen Institute, Oslo Diakonale Hospital, 0456, Oslo, Norway.; Department of Molecular Medicine, University of Oslo, 0372, Oslo, Norway., Raastad T; Department of Physical Performance, Norwegian School of Sports Sciences, 0863, Oslo, Norway., Karasik D; Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.; Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 1311502, Israel., van de Peppel J; Department of Internal Medicine, Erasmus MC University, Rotterdam, 3015GE, The Netherlands., Jaddoe VWV; The Generation R Study Group, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands., Uitterlinden AG; Department of Internal Medicine, Erasmus MC University, Rotterdam, 3015GE, The Netherlands.; The Generation R Study Group, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands., Tobias JH; School of Clinical Sciences, University of Bristol, Bristol, BS10 5NB, UK., Grant SFA; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Bagos PG; Department of Computer Science and Biomedical Informatics of the University of Thessaly, Lamia, GR 35100, Greece., Evans DM; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, 4102, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK., Rivadeneira F; Department of Internal Medicine, Erasmus MC University, Rotterdam, 3015GE, The Netherlands. f.rivadeneira@erasmusmc.nl.; The Generation R Study Group, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands. f.rivadeneira@erasmusmc.nl.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands. f.rivadeneira@erasmusmc.nl.

Publikováno v: Nature communications [Nat Commun] 2017 Jul 25; Vol. 8 (1), pp. 121. Date of Electronic Publication: 2017 Jul 25.