Zobrazeno 1 - 10
of 20
pro vyhledávání: '"C J Molineaux"'
Autor:
Eric E. Allen, C J Molineaux, Lorraine Malkowitz, Debra Ondeyka, Salvatore J. Siciliano, Nathan B. Mantlo, Bing Li, Ralph A. Rivero, William J. Greenlee, S. E. De Laszlo, Martin S. Springer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:213-218
The structural optimization for binding affinity and attempted modification of agonist function of a nonpeptide ligand of the human C5a receptor is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a524b49d8b119f92268a7358ba0a44d1
https://doi.org/10.1016/s0960-894x(96)00606-3
https://doi.org/10.1016/s0960-894x(96)00606-3
Autor:
Z D Konteatis, S J Siciliano, G Van Riper, C J Molineaux, S Pandya, P Fischer, H Rosen, R A Mumford, M S Springer
Publikováno v:
The Journal of Immunology. 153:4200-4205
C5a is a 74-amino acid glycoprotein generated on activation of the C system. The responses evoked by C5a, both in vitro and in vivo, and its association with inflammatory diseases, suggest that a receptor antagonist would be of considerable therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::310a8826b3aab1835b2f9d03f6b66d1b
https://doi.org/10.4049/jimmunol.153.9.4200
https://doi.org/10.4049/jimmunol.153.9.4200
Autor:
S. E. De Laszlo, C J Molineaux, Martin S. Springer, Salvatore J. Siciliano, Nathan B. Mantlo, Lorraine Malkowitz, Debra Ondeyka, William J. Greenlee, Eric E. Allen, Ralph A. Rivero, Bing Li
Publikováno v:
ChemInform. 28
The structural optimization for binding affinity and attempted modification of agonist function of a nonpeptide ligand of the human C5a receptor is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bcdafe425631946a61942a85ede0a67
https://doi.org/10.1002/chin.199720171
https://doi.org/10.1002/chin.199720171
Publikováno v:
Endocrinology. 130:1173-1179
CRF stimulates beta-endorphin (beta EP) secretion from adult rat Leydig cells in vitro. To evaluate the relevance of this action of CRF in a physiological context, we studied the effect of CRF on beta EP secretion in the testis in whole animals. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b0c5a88fd28a12408cc6b70d0060fb
https://doi.org/10.1210/endo.130.3.1537283
https://doi.org/10.1210/endo.130.3.1537283
Autor:
C J Molineaux, Eric M. Genden
Publikováno v:
Hypertension. 18:360-365
The potent vasodilatory peptide bradykinin is cleaved at the Phe5-Ser6 bond in vitro by the metalloenzyme endopeptidase-24.15 (E.C.3.4.24.15). We now report that intravenous infusion of N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739a45d6ec9e3d5d3a151cbdaac118ea
https://doi.org/10.1161/01.hyp.18.3.360
https://doi.org/10.1161/01.hyp.18.3.360
Autor:
Z D, Konteatis, S J, Siciliano, G, Van Riper, C J, Molineaux, S, Pandya, P, Fischer, H, Rosen, R A, Mumford, M S, Springer
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 153(9)
C5a is a 74-amino acid glycoprotein generated on activation of the C system. The responses evoked by C5a, both in vitro and in vivo, and its association with inflammatory diseases, suggest that a receptor antagonist would be of considerable therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44dbfecdf44de9df70693a7c840a5bc1
https://pubmed.ncbi.nlm.nih.gov/7930622
https://pubmed.ncbi.nlm.nih.gov/7930622
Autor:
J A, DeMartino, G, Van Riper, S J, Siciliano, C J, Molineaux, Z D, Konteatis, H, Rosen, M S, Springer
Publikováno v:
The Journal of biological chemistry. 269(20)
The binding domain of the human C5a receptor consists of two distinct and physically separable subsites. One of these sites binds the C-terminal 8 amino acids of C5a and is as yet undefined, while the second site lies in the N terminus of the recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18c8c21f9cd9a87390e7bccb13e87b7e
https://pubmed.ncbi.nlm.nih.gov/8182049
https://pubmed.ncbi.nlm.nih.gov/8182049
Autor:
J A, Schriefer, C J, Molineaux
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 266(2)
Bradykinin (BK) affects a variety of smooth muscle types, including uterus. These effects are generally short-lived due to metabolism by a variety of enzymes including angiotensin converting enzyme (ACE), endopeptidase 24.11 (EP-24.11) and endopeptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45cc46f4700f36b41b633c8c88b82db7
https://pubmed.ncbi.nlm.nih.gov/8394914
https://pubmed.ncbi.nlm.nih.gov/8394914
Publikováno v:
The International journal of neuroscience. 56(1-4)
Endopeptidase 24.15, a metalloendopeptidase active in brain, rapidly converts prodynorphin-derived peptides into leu-enkephalin. Inhibitors of this enzyme slow the degradation of these peptides in vivo and in vitro. The present study evaluated two in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfe02738260b3e7567d788b433edbc7
https://pubmed.ncbi.nlm.nih.gov/1938129
https://pubmed.ncbi.nlm.nih.gov/1938129
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 249:E244-E250
The effect of hemorrhagic shock (40% of blood vol) on the distribution of immunoreactive dynorphin A (Dyn A-IR), [Arg8]vasopressin (AVP-IR), and [Leu5]enkephalin (LE-IR) in the pituitary and brain nuclei was studied in the conscious rat. At 24 h afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3c90a128da7a8db612c20dd7c81b5b
https://doi.org/10.1152/ajpendo.1985.249.3.e244
https://doi.org/10.1152/ajpendo.1985.249.3.e244