Zobrazeno 1 - 10
of 41
pro vyhledávání: '"C J Hackbarth"'
Publikováno v:
Journal of Antimicrobial Chemotherapy. 55:ii21-ii24
Objectives: Dalbavancin is a novel, semi-synthetic glycopeptide antibiotic. The aim of this study was to further explore its activity against staphylococci. Methods: The bactericidal activity of dalbavancin was studied using MBC and time-kill methods
Autor:
Janice M. Friis, Charlotte Wu, Sara E. Morin, Joaquim Trias, Bore Raju, Wade J. Adams, Ford Charles W, Ronda D. Schaadt, Stuart Lam, Joe Palandra, Dinesh V. Patel, Joseph Zhou, Maria Courtney, Mikhail F. Gordeev, Sara Lopez, Gary E. Zurenko, C J Hackbarth, Upinder Singh, Robert C. Gadwood, Zhengyu Yuan, Kathleen Mortell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4209-4212
Combinatorial libraries of N-acylated 5-(S)-aminomethyloxazolidinone derivatives of S-oxide and S,S-dioxide tetrahydro-4(2H)-thiopyranyl and thiomorpholine phenyloxazolidinone series have been synthesized on a solid phase and evaluated for antimicrob
Autor:
Shaoqing Chen, Stuart Lam, Romeo Ciabatti, Joaquim Trias, Richard White, Gianpaolo Candiani, C J Hackbarth, Jeffrey W. Jacobs, Stefano Donadio, Eric M. Gordon, Jeffrey Clough, Gabriella Romano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3409-3414
Thiazole peptide GE2270 A (1) possesses potent antimicrobial activity against many gram-positive pathogens, including methicillin resistant Staphylococcus aureus (S. aureus, MRSA; MIC(90)=0.06 microg/mL) and vancomycin resistant Enterococcus spp. (VR
Autor:
Dennis C. Young, Richard C. White, Dawn Chen, Zhengyu Yuan, Peter S. Margolis, Joaquim Trias, C J Hackbarth, Wen Wang
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:1825-1831
Peptide deformylase, a bacterial enzyme, represents a novel target for antibiotic discovery. Two deformylase homologs, defA and defB , were identified in Staphylococcus aureus . The defA homolog, located upstream of the transformylase gene, was ident
Publikováno v:
Antimicrobial Agents and Chemotherapy. 43:2742-2746
Levofloxacin is among the more active fluoroquinolones against streptococci and staphylococci. It is effective against moderately severe infections caused by these organisms, but its efficacy in the treatment of bacteremia and serious infections such
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:1768-1774
To characterize mechanisms of resistance to fluoroquinolones by Mycobacterium tuberculosis, mutants of strain H37Ra were selected in vitro with ofloxacin. Their quinolone resistance-determining regions for gyrA and gyrB were amplified and sequenced t
Publikováno v:
Biochemical Journal. 301:139-144
Reduced affinity of penicillin-binding proteins (PBPs) for binding penicillin has been proposed as a mechanism of beta-lactam antibiotic resistance in staphylococci. Penicillin binding by PBPs of three penicillin-susceptible and two penicillin-resist
Autor:
Henry F. Chambers, C J Hackbarth
Publikováno v:
Antimicrobial Agents and Chemotherapy. 37:1144-1149
For Staphylococcus aureus, it is hypothesized that two genes located upstream of the beta-lactamase gene, blaZ, are required for the inducible expression of beta-lactamase. blaR1 is predicted to encode a signal-transducing membrane protein, and blaI
Autor:
Zhengyu Yuan, Bore Raju, Marcela Gomez, Joaquim Trias, Hardwin O'dowd, Bum Tae Kim, Prudencio Herradura, Dinesh V. Patel, Shihai Gu, Richard C. White, Wen Wang, Sampath-Kumar Anandan, Charlotte Wu, C J Hackbarth
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(12)
Deoxynegamycin (1b) is a protein synthesis inhibitor with activity against Gram-negative (GN) bacteria. A series of conformationally restricted analogs were synthesized to probe its bioactive conformation. Indeed, some of the constrained analogs were
Autor:
Dinesh V. Patel, Richard C. White, Zhengyu Yuan, Charlotte Wu, Kathleen Mortell, Marcela Gomez, Wen Wang, Joaquim Trias, Hardwin O'dowd, Bore Raju, Sampath-Kumar Anandan, Hongwu Gao, C J Hackbarth
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(14)
Negamycin 1 is a bactericidal antibiotic with activity against Gram-negative bacteria, and served as a template in an antibiotic discovery program. An orthogonally protected β-amino acid derivative 3a was synthesized and used in parallel synthesis o