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Transgenic Mice With Increased Copper/Zinc–Superoxide Dismutase Activity Are Resistant to Hepatic Leukostasis and Capillary No-Reflow After Gut Ischemia/Reperfusion

Autor: Joe M. McCord, Sonia C. Flores, Robert E. Wolf, D. N. Granger, Y Horie, C J Epstein

Publikováno v: Circulation Research. 83:691-696

Abstract —The objectives of this study were to (1) determine whether transgenic (Tg) mice overexpressing copper/zinc–superoxide dismutase (CuZn-SOD) are protected from the deleterious effects of gut ischemia/reperfusion (I/R) and (2) compare the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c17ac390d516b6f9159777aa5f780a
https://doi.org/10.1161/01.res.83.7.691

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Pleiotropic effects of the mouse lethal yellow (A y) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs

Autor: Mary E. Stevens, M. W. Miller, P. J. Saxon, Gregory S. Barsh, David M. J. Duhl, C. J. Epstein, Harry Vrieling

Publikováno v: Development. 120:1695-1708

Heterozygosity for the mouse lethal yellow(Ay) mutation leads to obesity, increased tumor susceptibility and increased activity of the agouti coat color gene; homozygosity for Ay results in embryonic death around the time of implantation. Although th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0856a8f5faa53f9413b19c4d242c5b
https://doi.org/10.1242/dev.120.6.1695

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The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene

Autor: M. W. Miller, B. M. Winkes, F. Arredondo-Vega, P. J. Saxon, Gregory S. Barsh, C. J. Epstein, David M. J. Duhl, Michael S. Hershfield, G. L. Wolff

Publikováno v: The EMBO Journal. 13:1806-1816

The lethal nonagouti (a(x)) mutation is a hypomorphic allele of the agouti coat color locus which, when homozygous, also leads to embryonic death around the time of implantation. To understand the molecular basis of these phenotypes, we identified an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1893583c26ef1d8d3348f02bd56bb86
https://doi.org/10.1002/j.1460-2075.1994.tb06449.x

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Mouse intestinal goblet cells expressing SV40 T antigen directed by the MUC2 mucin gene promoter undergo apoptosis upon migration to the villi

Autor: J R, Gum, J W, Hicks, A M, Gillespie, J L, Rius, P A, Treseler, S C, Kogan, E J, Carlson, C J, Epstein, Y S, Kim

Publikováno v: Cancer research. 61(8)

Mucinous colorectal cancers exhibit a characteristic set of molecular genetic alterations and may be derived from progenitor cells committed to the goblet cell lineage. Previously, we demonstrated that the MUC2 mucin gene promoter drives transgene re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb62bae742e15b12a7fb5027759d71b4
https://pubmed.ncbi.nlm.nih.gov/11309310

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Overexpression of manganese superoxide dismutase (MnSOD) in whole lung or alveolar type II cells of MnSOD transgenic mice does not provide intrinsic lung irradiation protection

Autor: M W, Epperly, E L, Travis, J A, Whitsett, I, Raineri, C J, Epstein, J S, Greenberger

Publikováno v: International journal of cancer. 96(1)

Intratracheal (IT) injection of the transgene for human manganese superoxide dismutase in plasmid/liposome (SOD2-PL) complex prior to irradiation protects C57BL/6J mice from whole lung irradiation-induced organizing alveolitis/fibrosis. Transgene mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89d689a4827fea383202de2c0f37fd33
https://pubmed.ncbi.nlm.nih.gov/11241326

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Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis

Autor: O A, Andreassen, R J, Ferrante, P, Klivenyi, A M, Klein, L A, Shinobu, C J, Epstein, M F, Beal

Publikováno v: Annals of neurology. 47(4)

The pathogenesis of neuronal cell death as a consequence of mutations in copper/zinc superoxide dismutase (SOD1) associated with familial amyotrophic lateral sclerosis may involve oxidative damage and mitochondrial dysfunction. We examined whether cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bae5d4ca70bee6eb4ba092b2821fda59
https://pubmed.ncbi.nlm.nih.gov/10762155

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Studies of Neuronal Necrosis and Apoptosis after Global Cerebral Ischemia in Superoxide Dismutase Transgenic and Knockout Mutants

Autor: K. Murakami, Miki Fujimura, Yuiko Morita-Fujimura, T. Kondo, Makoto Kawase, S. F. Chen, R. W. Scott, P. H. Chan, C. J. Epstein

Publikováno v: Maturation Phenomenon in Cerebral Ischemia III ISBN: 9783540650232

We have demonstrated that copper zinc-superoxide dismutase (CuZnSOD), a cytosolic isoenzyme of SOD, has a protective role in the pathogenesis of superoxide-radical-mediated brain injury, including focal transient ischemia/reperfusion and excitotoxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffb0f2e300a99d1f73f0a21b337e911b
https://doi.org/10.1007/978-3-642-58602-6_7

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Novel mutations in an otherwise strictly conserved domain of CuZn superoxide dismutase

Autor: R M, Luche, R, Maiwald, E J, Carlson, C J, Epstein

Publikováno v: Molecular and cellular biochemistry. 168(1-2)

All mutations in the human gene for CuZn superoxide dismutase (CuZnSOD) reported to date are associated with the disease amyotrophic lateral sclerosis (ALS). These mutations, mostly of a familial nature (ALS 1, MIM 105400), span all of the coding reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f986a334248abd9309e8a35a8e50fe02
https://pubmed.ncbi.nlm.nih.gov/9062909

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