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Akademický článek

Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency

Autor: David C. Jürgens, Leonie Deßloch, Diana Porras-Gonzalez, Joshua Winkeljann, Sebastian Zielinski, Matthias Munschauer, Andreas L. Hörner, Gerald Burgstaller, Benjamin Winkeljann, Olivia M. Merkel

Publikováno v: OpenNano, Vol 12, Iss , Pp 100161- (2023)

Lipid Nanoparticles (LNPs) are promising drug delivery systems for various RNAs such as small interfering (siRNA) and messenger RNA (mRNA). Microfluidic mixing is a common technique to encapsulate RNA in LNPs. However, high flow rates and lipid conce

Externí odkaz: https://doaj.org/article/ab2f0b7a736b4f48a959f68d35d4ba31

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Akademický článek

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Targeted GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma

Autor: Rima Kandil, Domizia Baldassi, Sebastian Böhlen, Joschka T. Müller, David C. Jürgens, Tonia Bargmann, Susann Dehmel, Yuran Xie, Aditi Mehta, Katherina Sewald, Olivia M. Merkel

GATA3 gene silencing in activated T cells displays a promising option to early-on undermine pathological pathways in the disease formation of allergic asthma. The central transcription factor of T helper 2 (Th2) cell cytokines IL-4, IL-5, and IL-13 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68da4d25421e2c7c46cec7acbb0f1e18
https://publica.fraunhofer.de/handle/publica/439564

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Entfernung eines verbogenen Femurnagels

Autor: M. Wenzel, A. P. Schulz, S. Fuchs, K. H. Frosch, C. Jürgens

Publikováno v: Die Unfallchirurgie.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1b22eadfb0419b040b0fd9ae0cc4faf
https://doi.org/10.1007/s00113-022-01219-3

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[Removal of a bent femoral nail : Case report: treatment strategy of a complex femoral deformity with a bent femoral nail in situ since 36 years]

Autor: M, Wenzel, A P, Schulz, S, Fuchs, K H, Frosch, C, Jürgens

Publikováno v: Unfallchirurgie (Heidelberg, Germany)LiteraturVerwendete LiteraturWeiterführende Literatur.

To remove a bent femoral nail is always a challenging task for a surgeon. In the last 20 years several case reports and descriptions of techniques are to be found in literature, the goal being to weaken the nail at the apex and then straightening it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aaa2c3c16c72061c87ea892d72710dbf
https://pubmed.ncbi.nlm.nih.gov/35943548

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Implementation of a regional video multidisciplinary team meeting is associated with an improved prognosis for patients with oesophageal cancer A mixed methods approach

Autor: J. E. Vincent, Wouter L. Curvers, Erik H.C.J. Buster, Clément J. Huysentruyt, Josianne Luijten, Matthias C. Jürgens, Misha D. P. Luyer, Jan Kees Kneppelhout, Ruud W. M. Schrauwen, Vera C. Haagsman, Fanny B.M. Heesakkers, Joost Nederend, Grard A. P. Nieuwenhuijzen, Geert-Jan Creemers, Maurice J.C. van der Sangen, Rob H.A. Verhoeven, Pauline A. J. Vissers

Publikováno v: Luijten, J C H B M, Haagsman, V C, Luyer, M D P, Vissers, P A J, Nederend, J, Huysentruyt, C, Creemers, G-J, Curvers, W, van der Sangen, M, Heesakkers, F B M, Schrauwen, R W M, Jürgens, M C, Buster, E H C J, Vincent, J, Kneppelhout, J K, Verhoeven, R H A & Nieuwenhuijzen, G A P 2021, ' Implementation of a regional video multidisciplinary team meeting is associated with an improved prognosis for patients with oesophageal cancer A mixed methods approach ', European Journal of Surgical Oncology, vol. 47, no. 12, pp. 3088-3096 . https://doi.org/10.1016/j.ejso.2021.04.020
European Journal of Surgical Oncology, 47(12), 3088-3096. W.B. Saunders Ltd
European Journal of Surgical Oncology, 47, 12, pp. 3088-3096
European Journal of Surgical Oncology, 47, 3088-3096
European journal of surgical oncology, 47(12), 3088-3096. W.B. Saunders Ltd

Background: Studies have shown that multidisciplinary team meetings (MDTM) improve diagnostic work-up and treatment-decisions. This study aims to evaluate the influence of implementing a regional-video-Upper-GI-MDTM (uMDTM) for oesophageal cancer (OC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd3ac275e65c1164c5cfb6740662dbd
https://research.vumc.nl/en/publications/469d1496-30aa-4e39-bf9f-ac97ee8ab2c8

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