Výsledky vyhledávání - "C J, Saranko"

1,3-butadiene: cancer, mutations, and adducts. Part II: Roles of two metabolites of 1,3-butadiene in mediating its in vivo genotoxicity

Autor: L, Recio, C J, Saranko, A M, Steen

Publikováno v: Research report (Health Effects Institute). (92)

1,3-Butadiene (BD) is carcinogenic in mice and rats, with mice being more susceptible than rats to its carcinogenic effects. 1,3-Butadiene is mutagenic in the bone marrow and spleen cells of B6C3F1 lacI transgenic mice. The goal of this research was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76d774875a4e2f349ba40f8237c9ab41
https://pubmed.ncbi.nlm.nih.gov/10925839

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The butadiene metabolite, 1,2:3,4-diepoxybutane, induces micronuclei but is only weakly mutagenic at lacI in the Big Blue Rat2 lacI transgenic cell line

Autor: C J, Saranko, L, Recio

Publikováno v: Environmental and molecular mutagenesis. 31(1)

1,3-Butadiene (BD) is a genotoxic carcinogen that is bioactivated to at least two mutagenic metabolites, 1,2-epoxybutene (EB) and 1,2:3,4-diepoxybutane (DEB). We investigated the mutagenicity and induction of micronuclei by DEB in vitro in Rat2 lambd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3d92ae932b9edbd43640c687ce772533
https://pubmed.ncbi.nlm.nih.gov/9464313

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Assessment of 1,3-butadiene mutagenicity in the bone marrow of B6C3F1 lacI transgenic mice (Big Blue): a review of mutational spectrum and lacI mutant frequency after a 5-day 625 ppm 1,3-butadiene exposure

Autor: L, Recio, K G, Meyer, L J, Pluta, O R, Moss, C J, Saranko

Publikováno v: Environmental and molecular mutagenesis. 28(4)

1,3-Butadiene (BD) is a carcinogen that is bioactivated to at least two genotoxic metabolites. In the present article, we review briefly our previous studies on the in vivo mutagenicity and mutational spectra of BD in bone marrow and extend these stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ac0a94d318264e0d7e25aa310a60d5e
https://pubmed.ncbi.nlm.nih.gov/8991073

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