Zobrazeno 1 - 10
of 16
pro vyhledávání: '"C J, Refino"'
Publikováno v:
Circulation. 92:3032-3040
Background The thrombolytic properties of a new variant of tissue plasminogen activator (TPA) (T103N, N117Q, KHRR 296-299 AAAA, or TNK-TPA) with longer plasma half-life, greater fibrin specificity, and increased resistance to inhibition by plasminoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433c800a15fc4a8747e24f84a491ae90
https://doi.org/10.1161/01.cir.92.10.3032
https://doi.org/10.1161/01.cir.92.10.3032
Publikováno v:
Thrombosis and haemostasis. 82(3)
10C12, a human antibody F(ab')2, which specifically binds to the Gla domain of factor IX, interfered with all known coagulation processes that involve factor IX/IXa. These include the function of the intrinsic Xase complex and the activation of zymog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73fb3113446b6f300a9caf758416a630
https://pubmed.ncbi.nlm.nih.gov/10494786
https://pubmed.ncbi.nlm.nih.gov/10494786
Publikováno v:
Blood. 89(9)
One approach to developing safer and more efficacious agents for the treatment of thrombotic disease involves the design and testing of inhibitors that block specific steps in the coagulation cascade. We describe here the development of a mutant of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::36dd8d991812dab54717f03493ddc8f2
https://pubmed.ncbi.nlm.nih.gov/9129026
https://pubmed.ncbi.nlm.nih.gov/9129026
Autor:
G R, Thomas, H, Thibodeaux, C J, Errett, J M, Badillo, D T, Wu, C J, Refino, B A, Keyt, W F, Bennett
Publikováno v:
Thrombosis and haemostasis. 75(6)
Clinical experience suggests that thrombolytic-induced bleeding is associated with systemic activation of the thrombolytic system. Using fibrin specific variants of tissue-type plasminogen activator (t-PA) and making use of the apparent fibrin specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63570c0eb08e8fa7e6836300c4ae85c2
https://pubmed.ncbi.nlm.nih.gov/8822586
https://pubmed.ncbi.nlm.nih.gov/8822586
Publikováno v:
Thrombosis and haemostasis. 75(5)
Multiple clinical trials have proven that thrombolytic therapy is an effective treatment for acute myocardial infarction. Spontaneous intracranial hemorrhage (ICH) occurs in a small percentage of patients as a result of the treatment. The etiology of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29ce8c8f1f42d433fa9785dc46ca856f
https://pubmed.ncbi.nlm.nih.gov/8725730
https://pubmed.ncbi.nlm.nih.gov/8725730
Autor:
J Lai, Luis C. Pena, L. Berleau, Bruce Keyt, C Pater, J Ogez, C J Refino, Alice M. Chow, N F Paoni, Hung V. Nguyen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 91(9)
Current treatment with tissue plasminogen activator (tPA) requires an intravenous infusion (1.5-3 h) because the clearance of tPA from the circulation is rapid (t 1/2 approximately 6 min). We have developed a tPA variant, T103N,N117Q, KHRR(296-299)AA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b49fb3a4f0dddb5dc487a719699f5f
https://pubmed.ncbi.nlm.nih.gov/8170967
https://pubmed.ncbi.nlm.nih.gov/8170967
Autor:
C J, Refino, N F, Paoni, B A, Keyt, C S, Pater, J M, Badillo, F M, Wurm, J, Ogez, W F, Bennett
Publikováno v:
Thrombosis and haemostasis. 70(2)
In the accompanying paper, we reported that the properties of decreased plasma clearance rate, increased fibrin specificity, and resistance to inactivation by PAI-1 could be effectively combined in the t-PA variant T103N, KHRR 296-299 AAAA. In the cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c6b192b846722a41468d06a77518873
https://pubmed.ncbi.nlm.nih.gov/8236141
https://pubmed.ncbi.nlm.nih.gov/8236141
Autor:
N F, Paoni, B A, Keyt, C J, Refino, A M, Chow, H V, Nguyen, L T, Berleau, J, Badillo, L C, Peña, K, Brady, F M, Wurm
Publikováno v:
Thrombosis and haemostasis. 70(2)
Site directed mutagenesis was used to construct a t-PA variant that contains an additional glycosylation site in the first kringle domain (T103N) combined with a tetra-alanine substitution in the protease domain (KHRR 296-299 AAAA). This combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e25aff08b11cbf1f52f1f4fbe64f769f
https://pubmed.ncbi.nlm.nih.gov/8236140
https://pubmed.ncbi.nlm.nih.gov/8236140
Autor:
C. J. Refino, Casey M. Donovan, Peter R. Dallman, Kelvin J.A. Davies, Lester Packer, George A. Brooks
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 246:E535-E543
Three weeks of dietary iron deficiency in weanling rats resulted in anemia (Hb, 3.9 vs. 14.2 g/dl in controls) and decreased oxidative capacities of skeletal muscle (as much as 90% below control values). Whole-animal maximal O2 consumption (VO2max),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ae3c0e2db9ecda30414b01f7b8b8f5
https://doi.org/10.1152/ajpendo.1984.246.6.e535
https://doi.org/10.1152/ajpendo.1984.246.6.e535
Autor:
A Hotchkiss, C J Refino, C K Leonard, J V O'Connor, C Crowley, J McCabe, K Tate, G Nakamura, D Powers, A Levinson, M Mohler, M W Spellman
Publikováno v:
Thrombosis and Haemostasis. 60:255-261
SummaryModification of the carbohydrate structures of recombinant tissue-type plasminogen activator (rt-PA) can increase or decrease its rate of clearance in rabbits. When rt-PA was treated with sodium periodate to oxidize carbohydrate residues, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dda24a20a8703f116333944a39a1ccd
https://doi.org/10.1055/s-0038-1647041
https://doi.org/10.1055/s-0038-1647041