Zobrazeno 1 - 10
of 63
pro vyhledávání: '"C J, Musante"'
Autor:
Anna, Kondic, Dean, Bottino, John, Harrold, Jeffrey D, Kearns, C J, Musante, Aleksandrs, Odinecs, Saroja, Ramanujan, Jangir, Selimkhanov, Birgit, Schoeberl
Publikováno v:
Frontiers in Pharmacology. 13
The goal of this mini-review is to summarize the collective experience of the authors for how modeling and simulation approaches have been used to inform various decision points from discovery to First-In-Human clinical trials. The article is divided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4960bae4a8a25b77d1e696a43b883c98
https://doi.org/10.3389/fphar.2022.860881
https://doi.org/10.3389/fphar.2022.860881
Autor:
S. Longobardi, A. Lewalle, S. Coveney, I. Sjaastad, E. K. S. Espe, W. E. Louch, C. J. Musante, A. Sher, S. A. Niederer
Cardiac contraction is the result of integrated cellular, tissue and organ function. Biophysical in silico cardiac models offer a systematic approach for studying these multi-scale interactions. The computational cost of such models is high, due to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099502cb78e7cc98a9577085e9e40f30
Autor:
S. Longobardi, A. Lewalle, S. Coveney, I. Sjaastad, E. K. S. Espe, W. E. Louch, C. J. Musante, A. Sher, S. A. Niederer
Cardiac contraction is the result of integrated cellular, tissue and organ function. Biophysical in silico cardiac models offer a systematic approach for studying these multi-scale interactions. The computational cost of such models is high, due to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f26ee70639cb3a188d6755f32721c266
Publikováno v:
Inhalation Toxicology. 13:307-356
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c53dfa07a67f43a718178a35f066cd4
https://doi.org/10.1080/089583701750127412
https://doi.org/10.1080/089583701750127412
Publikováno v:
Mathematical and Computer Modelling. 33(1-3):49-64
A distributed parameter model describing spatially-dependent hepatic processing of the chemical compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) has previously been reported [1]. The mathematical system consists of coupled nonlinear part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8536102c4ed3db8c8e9ed0c0166ec44
Autor:
T. B. Martonen, C. J. Musante
Publikováno v:
Inhalation Toxicology. 12:261-280
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f13b57da04a1f17d92b01606f20dc5ab
https://doi.org/10.1080/089583700750019602
https://doi.org/10.1080/089583700750019602
Autor:
C. J. Musante, Ted B. Martonen
Publikováno v:
Inhalation Toxicology. 12:261-280
Deposition patterns of mainstream cigarette smoke were studied in casts of human extrathoracic and lung airways. The laboratory tests were designed to simulate smoking (i.e., the behavior of undiluted cigarette smoke in smokers' lungs), not secondary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f03b88f8bcd7b770207c95630b18463
https://doi.org/10.1080/08958370050165120
https://doi.org/10.1080/08958370050165120
Autor:
C. J. Musante, Harvey Thomas Banks
Publikováno v:
Nonlinear Analysis: Theory, Methods & Applications. 35:629-648
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b429a87589f161c1f6d929bc15a0da4
https://doi.org/10.1016/s0362-546x(98)00053-4
https://doi.org/10.1016/s0362-546x(98)00053-4
Publikováno v:
Mathematical and Computer Modelling. 28(1):9-29
A convection-dispersion model for the uptake and elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the liver is presented. The model is adapted from the general dispersion model of Roberts and Rowland and includes the dynamics of TCDD inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93a67fe1b12442795723eb834da1392
Publikováno v:
Inhalation toxicology. 13(4)
Nonhuman primates may be used as human surrogates in inhalation exposure studies to assess either the (1) adverse health effects of airborne particulate matter or (2) therapeutic effects of aerosolized drugs and proteins. Mathematical models describi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6453627d76d77269e779e6f5fa0a427e
https://pubmed.ncbi.nlm.nih.gov/11295864
https://pubmed.ncbi.nlm.nih.gov/11295864