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Autor: C J, Melief, R, Offringa, R E, Toes, W M, Kast

Publikováno v: Current Opinion in Immunology. 8:651-657

The application of molecularly defined vaccines composed of a limited number of tumor-specific T cell epitopes has resulted in protective antitumor T cell immunity in several mouse tumor models. The first encouraging results with such vaccines have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f7220b4a31cd6156edbdeec3359ab1
https://doi.org/10.1016/s0952-7915(96)80081-1

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Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors

Autor: R E Toes, R J Blom, R Offringa, W M Kast, C J Melief

Publikováno v: The Journal of Immunology. 156:3911-3918

CTL can play an important role in the defense against tumors. Protective CTL-mediated immunity can be established in animal tumor models after vaccination with synthetic peptides representing CTL epitopes. We now report that immunization with synthet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::086a3d0a6bbbfc4d81ac0e54e274a451
https://doi.org/10.4049/jimmunol.156.10.3911

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Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability

Autor: S H van der Burg, M J Visseren, R M Brandt, W M Kast, C J Melief

Publikováno v: The Journal of Immunology. 156:3308-3314

The impact of the MHC class I peptide binding stability on the immunogenicity of particular peptide Ags in class I-restricted cytotoxic T lymphocyte responses is not clearly established. Therefore, we have determined the dissociation rate of each pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b24adf7417023c8c1c996a023bca6742
https://doi.org/10.4049/jimmunol.156.9.3308

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Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides

Autor: M E Ressing, A Sette, R M Brandt, J Ruppert, P A Wentworth, M Hartman, C Oseroff, H M Grey, C J Melief, W M Kast

Publikováno v: The Journal of Immunology. 154:5934-5943

Human papillomavirus type 16 (HPV16) is strongly associated with cervical carcinogenesis. The HPV16 E6 and E7 oncoproteins are constitutively expressed in the majority of cervical tumor cells and are, therefore, attractive targets for CTL-mediated im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac91211f92de007975420378149695f1
https://doi.org/10.4049/jimmunol.154.11.5934

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CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells

Autor: M J Visseren, A van Elsas, E I van der Voort, M E Ressing, W M Kast, P I Schrier, C J Melief

Publikováno v: The Journal of Immunology. 154:3991-3998

CTL that lyse melanoma cells were previously isolated from several melanoma patients. Such CTL recognize autologous proteins, indicating the occurrence of autoreactive T cells in melanoma patients. We have now raised CTL, using responding T lymphocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc76e6c3e639aeaf4ca7718e6360cb9f
https://doi.org/10.4049/jimmunol.154.8.3991

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An adenovirus type 5 early region 1B-encoded CTL epitope-mediating tumor eradication by CTL clones is down-modulated by an activated ras oncogene

Autor: R E Toes, R Offringa, R J Blom, R M Brandt, A J van der Eb, C J Melief, W M Kast

Publikováno v: The Journal of Immunology. 154:3396-3405

Mouse embryo cells (C57BL/6, H-2b) transformed by the E1A and E1B genes of adenovirus type 5 (Ad5E1 MEC) are highly immunogenic. Previously, CTL were cloned from mice immunized with Ad5E1 MEC. These CTL clones were capable of tumor eradication in nud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cfd96ab6caa4eb36c081bf7c1545239
https://doi.org/10.4049/jimmunol.154.7.3396

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Immunodominant mink cell focus-inducing murine leukemia virus (MuLV)-encoded CTL epitope, identified by its MHC class I-binding motif, explains MuLV-type specificity of MCF-directed cytotoxic T lymphocytes

Autor: A J Sijts, F Ossendorp, E A Mengedé, P J van den Elsen, C J Melief

Publikováno v: The Journal of Immunology. 152:106-116

H-2b mice are immunologic responders to the tumorigenic MCF1233 murine leukemia virus (MuLV), an AKV-related virus derived from endogenous C57BL MuLV. We have identified an immunodominant CTL epitope that is expressed on MCF1233 MuLV-induced lymphoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::173ea5e472cafde1b076e79e380ed8d7
https://doi.org/10.4049/jimmunol.152.1.106

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Genomic organization and chromosomal localization of the human CD27 gene

Autor: W A Loenen, L A Gravestein, S Beumer, C J Melief, A Hagemeijer, J Borst

Publikováno v: The Journal of Immunology. 149:3937-3943

CD27 is a lymphocyte-specific member of a recently identified receptor family with at least 10 members that includes the receptors for nerve growth factor and TNF, CD40, and Fas. Several members of this family play a role in cell differentiation, pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::184f88076a09f2741f12ae3ff4331616
https://doi.org/10.4049/jimmunol.149.12.3937

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