Zobrazeno 1 - 10
of 29
pro vyhledávání: '"C J, McCabe"'
Autor:
W, Imruetaicharoenchoke, A, Fletcher, W, Lu, R J, Watkins, B, Modasia, V L, Poole, H R, Nieto, R J, Thompson, K, Boelaert, M L, Read, V E, Smith, C J, McCabe
Publikováno v:
Endocrine-Related Cancer
Pituitary tumor-transforming gene 1-binding factor (PTTG1IP; PBF) is a multifunctional glycoprotein, which is overexpressed in a wide range of tumours, and significantly associated with poorer oncological outcomes, such as early tumour recurrence, di
Autor:
C. J. McCabe
Publikováno v:
Journal of Clinical Endocrinology & Metabolism. 84:649-653
Publikováno v:
Journal of endocrinological investigation. 35(4)
The pituitary tumor transforming gene (PTTG) is a multifunctional proto-oncogene that is over-expressed in various tumors including thyroid carcinomas, where it is a prognostic indicator of tumor recurrence. PTTG has potent transforming capabilities
Autor:
C J, McCabe, J S, Khaira, K, Boelaert, A P, Heaney, L A, Tannahill, S, Hussain, R, Mitchell, J, Olliff, M C, Sheppard, J A, Franklyn, N J L, Gittoes
Publikováno v:
Clinical endocrinology. 58(2)
Pituitary tumour transforming gene (PTTG) encodes a multifunctional protein that is implicated in initiating and perpetuating pituitary adenoma growth. PTTG appears to have key regulatory functions in determining control of many fundamental cellular
Autor:
L A, Tannahill, T J, Visser, C J, McCabe, S, Kachilele, K, Boelaert, M C, Sheppard, J A, Franklyn, N J L, Gittoes
Publikováno v:
Clinical endocrinology. 56(6)
Thyroid hormones (THs) perform essential roles in pituitary function. They regulate anterior pituitary hormone secretion and are also key determinants of pituitary cell proliferation and differentiation. The critical role of deiodinase enzymes, which
Publikováno v:
Pituitary. 1(2)
Estrogen (E2), acting via its nuclear receptors, has been implicated in tumor development and growth, particularly in the pathogenesis of breast cancer. E2 also modulates anterior pituitary hormone production and is a potent cell mitogen. Until recen
Publikováno v:
Clinical endocrinology. 50(6)
The MEN1 gene on chromosome 11q13 encodes a tumour suppressor gene, mutations in which cause multiple endocrine neoplasia (MEN) type 1 syndrome. Loss of heterozygosity (LOH) at this locus is a common finding amongst sporadic pituitary tumours. We hav