Zobrazeno 1 - 10
of 31
pro vyhledávání: '"C J, Grubbs"'
Autor:
G A, Piazza, W J, Thompson, R, Pamukcu, H W, Alila, C M, Whitehead, L, Liu, J R, Fetter, W E, Gresh, A J, Klein-Szanto, D R, Farnell, I, Eto, C J, Grubbs
Publikováno v:
Cancer research. 61(10)
Exisulind (Aptosyn) is a novel antineoplastic drug being developed for the prevention and treatment of precancerous and malignant diseases. In colon tumor cells, the drug induces apoptosis by a mechanism involving cyclic GMP (cGMP) phosphodiesterase
Autor:
C J, Grubbs, R A, Lubet, A T, Koki, K M, Leahy, J L, Masferrer, V E, Steele, G J, Kelloff, D L, Hill, K, Seibert
Publikováno v:
Cancer research. 60(20)
Epidemiological studies have shown that nonsteroidal anti-inflammatory drugs (NSAIDs) may have a role in the prevention of human cancers. A number of preclinical studies have also suggested that inhibition of cyclooxygenase (COX) with NSAIDs has an a
Publikováno v:
Anticancer research. 20(4)
The effect of chemopreventive agents on cancer multiplicity is of primary interest in animal studies. The nature of data collected from chemoprevention studies may be analyzed by a longitudinal analysis of repeatedly measured cancer multiplicity data
Autor:
J D, Haag, G M, Brasic, L A, Shepel, M A, Newton, C J, Grubbs, R A, Lubet, G J, Kelloff, M N, Gould
Publikováno v:
Molecular carcinogenesis. 24(1)
In this paper, patterns of allelic imbalances (Als) in chemically induced rat mammary, colon, and bladder tumors from (Wistar Furth x Fischer 344)F1 rats are described and compared. Male F1 rats were administered azoxymethane (AOM), and colon tumors
Autor:
Y F, Shealy, J L, Frye, D L, Hill, B P, Sani, T S, Rogers, J M, Riordan, C A, Krauth, T H, Lin, I, Eto, C J, Grubbs
Publikováno v:
Anti-cancer drug design. 13(3)
Recently, we reported that retinyl 2-propynyl ether (RPE) inhibits MNU-induced mammary cancer in rats and is less toxic than RME and retinyl acetate. The preparation and biological investigations of retinyl ethers have now been extended to retinyl su
Autor:
R A, Lubet, G B, Gordon, R A, Prough, X D, Lei, M, You, Y, Wang, C J, Grubbs, V E, Steele, G J, Kelloff, C F, Thomas, R D, Moon
Publikováno v:
Cancer research. 58(5)
Dehydroepiandrosterone (DHEA), the major steroid precursor of androgens and estrogens produced in peripheral tissues in primates, is an effective chemopreventive agent in the N-methyl-N-nitrosourea (MNU)-induced rat mammary tumor model. Dietary DHEA
Autor:
S M, Swanson, L M, Whitaker, C R, Stockard, R B, Myers, D, Oelschlager, W E, Grizzle, M M, Juliana, C J, Grubbs
Publikováno v:
Anticancer research. 17(6D)
Women who bear their first child by their late teens have about half the risk of developing breast cancer relative to nulliparous women. The rat is a good model for studying the role of hormones in breast cancer since, for example, young rats become
Publikováno v:
International journal of cancer. 72(1)
The chemopreventive efficacy of N-acetyl-L-cysteine (NAC), anethole trithione, miconazole and phenethylisothiocyanate (PEITC), each of which would be expected to alter carcinogen metabolism, was examined in the dimethylbenzanthracene (DMBA) mammary c
Autor:
Y F, Shealy, J L, Frye, J M, Riordan, D L, Hill, M, McPhillips, J J, Wille, B P, Sani, J R, Kalin, I, Eto, C J, Grubbs
Publikováno v:
Anti-cancer drug design. 12(1)
It had been demonstrated previously that retinyl methyl ether (RME) can suppress carcinogen-induced mammary cancers in vivo. It had also been shown that RME is demethylated enzymatically to retinol and produces the toxic effects of retinol; however,
Autor:
C J, Grubbs, V E, Steele, T, Casebolt, M M, Juliana, I, Eto, L M, Whitaker, K H, Dragnev, G J, Kelloff, R L, Lubet
Publikováno v:
Anticancer research. 15(3)
Indole-3-carbinol, a component of cruciferous vegetables, was evaluated for it efficacy in the prevention of chemically-induced mammary tumors using three different protocols. Because this compound was unstable, it was administered by gavage rather t