Zobrazeno 1 - 2
of 2
pro vyhledávání: '"C J, Gresk"'
Autor:
S K, Paulson, J Y, Zhang, A P, Breau, J D, Hribar, N W, Liu, S M, Jessen, Y M, Lawal, J N, Cogburn, C J, Gresk, C S, Markos, T J, Maziasz, G L, Schoenhard, E G, Burton
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(5)
The pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide, a cyclooxygenase-2 inhibitor, were investigated in rats. Celecoxib was metabolized exten
Autor:
S K, Paulson, T A, Kaprak, C J, Gresk, D M, Fast, M T, Baratta, E G, Burton, A P, Breau, A, Karim
Publikováno v:
Biopharmaceuticsdrug disposition. 20(6)
The plasma protein binding of celecoxib was determined for animals and humans using in vitro and ex vivo methods. Eight, healthy, human volunteers (three male, five female, 20-39 years) received celecoxib (600 mg) BID for 7 days, blood samples were c