Proteomic analysis reveals a potential role for extracellular vesicles within the erythroblastic island niche

Autor: Telma Ventura, Antonella Fidanza, Marieangela C. Wilson, Daniel C. J. Ferguson, Phillip A. Lewis, Alisha May, Helen Taylor, Michael P. Rimmer, Christopher D. Gregory, Jan Frayne, Lesley M. Forrester

Publikováno v: Frontiers in Molecular Biosciences, Vol 11 (2024)

Introduction: Erythroblastic island (EBI) macrophages play an essential role in the production and maturation of the vast numbers of red blood cells (RBCs) that are produced throughout life. Their location within the bone marrow makes it difficult to

Externí odkaz: https://doaj.org/article/efb4c16f8d8e4e2885212d3119f67a99

Erratum to: Comparing the two leading erythroid lines BEL-A and HUDEP-2

Autor: Deborah E. Daniels, Damien J. Downes, Ivan Ferrer-Vicens, Daniel C. J. Ferguson, Belinda K. Singleton, Marieangela C. Wilson, Kongtana Trakarnsanga, Ryo Kurita, Yukio Nakamura, David J. Anstee, Jan Frayne

Publikováno v: Haematologica, Vol 109, Iss 1 (2024)

Externí odkaz: https://doaj.org/article/4d782518f626402dbd7d20dbf0bff7ad

Novel human cellular model of CDA IV enables comprehensive analysis revealing molecular basis of disease phenotype

Autor: Ivan Ferrer-Vicens, Daniel C. J. Ferguson, Marieangela C Wilson, Kate J Heesom, James J Bieker, Jan Frayne

Publikováno v: Blood Journal.

Red blood cell disorders can result in severe anemia. One such disease, congenital dyserythropoietic anemia IV (CDA IV) is caused by heterozygous mutation E325K in the transcription factor KLF1. However, studying the molecular basis of CDA IV is seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fb0dd35367a0019b3f9d2638c87063f
https://doi.org/10.1182/blood.2022018735

Human cellular model systems of β-thalassemia enable in-depth analysis of disease phenotype

Autor: Deborah E Daniels, Ivan Ferrer-Vicens, J Hawksworth, Tatyana N Andrienko, Elizabeth M Finnie, Daniel C J Ferguson, A. Sofia F. Oliveira, Jenn-Yeu A. Szeto, Marieangela C Wilson, Jan Frayne

β-thalassemia is a prevalent genetic disorder causing severe anemia due to defective erythropoiesis, with few treatment options. Studying the underlying molecular defects is impeded by paucity of suitable patient material. In this study we created h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5852f8ee726a0d767ffc1a8c93246a3
https://doi.org/10.1101/2022.09.01.506225

Identification of the transcription factor MAZ as a regulator of erythropoiesis

Autor: Darya Deen, Jan Frayne, Matthias Mann, Daniel C. J. Ferguson, Helena Ayyub, Vasiliki Samara, Michelle L. Holland, Falk Butter, Jacqueline A. Sloane-Stanley, Douglas Vernimmen, Ivan Ferrer-Vicens, David Garrick, Deborah E. Daniels

Publikováno v: Deen, D, Butter, F, Daniels, D, Ferrer-Vicens, I, Vernimmen, D, Garrick, D, Holland, M L, Samara, V, Sloane-Stanley, J A, Ayyub, H, Mann, M, Frayne, J & Ferguson, D 2021, ' Identification of the transcription factor MAZ as a regulator of erythropoiesis ', Blood Advances, pp. 3002-3015 . https://doi.org/10.1182/bloodadvances.2021004609
Deen, D, Daniels, D E, Ferrer-Vicens, I, Ferguson, D C J, Frayne, J, Vernimmen, D & al., E 2021, ' Identification of the transcription factor MAZ as a regulator of erythropoiesis ', Blood Advances, vol. 5, no. 15, pp. 3002-3015 . https://doi.org/10.1182/bloodadvances.2021004609

Erythropoiesis requires a combination of ubiquitous and tissue-specific transcription factors (TFs). Here, through DNA affinity purification followed by mass spectrometry, we have identified the widely expressed protein MAZ (Myc-associated zinc finge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1803f22fa6b8a0383e0dd594d4ce65
https://pubmed.ncbi.nlm.nih.gov/35298619