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An early phase I study to determine the tolerance, safety and pharmacokinetics of idebenone following multiple oral doses

Autor: M F, Barkworth, C J, Dyde, K I, Johnson, K, Schnelle

Publikováno v: Arzneimittel-Forschung. 35(11)

Ten healthy male volunteers participated in this Phase I multiple dose study with CV-2619 (6-[10-hydroxydecyl]-2,3- dimethoxy-5-methyl-1,4-benzoquinone, idebenone). Each volunteer received single oral doses of 100 mg CV-2619 on study days 1 and 35, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b64f34ad5d29042e2122868725e5832
https://pubmed.ncbi.nlm.nih.gov/4091873

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The Determination of Suprofen in Biological Fluids

Autor: M. F. Barkworth, C. J. Dyde, K. D. Rehm

Publikováno v: Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular ISBN: 9781475794267

A simple and specific method for determining suprofen in biological fluids generated from pharmacokinetic studies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b66aeeb4a420201f2f9d3a2becfeaf90
https://doi.org/10.1007/978-1-4757-9424-3_15

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[Plasma level and action of sotalol-HCL on the ECG interval after parenteral administration in healthy subjects]

Autor: K D, Rehm, K, Schnelle, C J, Dyde, E, Blümner, W, Arendts

Publikováno v: Arzneimittel-Forschung. 37(9)

Sotalol (Sotalex; Sotacor) is a beta-blocker with additional class III antiarrhythmic activity. In this study two intravenous doses of 1.5 mg/kg and 2 mg/kg body weight were administered in 8 healthy volunteers in order to determine the pharmacokinet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f82764f164a815f167183662d5d2000d
https://pubmed.ncbi.nlm.nih.gov/3435602

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[Relative bioavailability of paracetamol from tablets and suppositories as well as of paracetamol and codeine in a combination tablet]

Autor: G, Klein, M F, Barkworth, A, Birkenfeld, C J, Dyde, K D, Rehm, H, Töberich, H, Cierpka

Publikováno v: Arzneimittel-Forschung. 36(3)

Eight healthy male volunteers took part in this study to determine the relative bioavailability of Treuphadol oblong tablets (500 mg paracetamol), Treuphadol Plus oblong tablets (500 mg paracetamol, 30 mg codeine phosphate) and Treuphadol suppositori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bfaefaf4b3923591e329665db0b68422
https://pubmed.ncbi.nlm.nih.gov/3518729

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Tolerance and pharmacokinetics of oral fendiline

Autor: R, Weyhenmeyer, E, Fenzl, M, Apecechea, K D, Rehm, C J, Dyde, K J, Johnson, R, Friedel

Publikováno v: Arzneimittel-Forschung. 37(1)

Two studies with healthy volunteers were carried out to correlate safety with pharmacokinetics of the calcium antagonistic drug N-(3,3-diphenylpropyl)-(1-phenylethyl)-amine (fendiline, Sensit) after single and multiple oral doses. In the first study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::132e5f55fa1f599be433f692d721dd1c
https://pubmed.ncbi.nlm.nih.gov/3566858

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