Výsledky vyhledávání - "C J, Carrera"

2-Chlorodeoxyadenosine: an active agent in the treatment of cutaneous T- cell lymphoma

Autor: A, Saven, C J, Carrera, D A, Carson, E, Beutler, L D, Piro

Publikováno v: Blood. 80:587-592

Cutaneous T-cell lymphomas are disfiguring malignant lymphoproliferative disorders for which standard therapy has been principally palliative. 2-Chlorodeoxyadenosine (2-CdA), a new purine analogue resistant to degradation by adenosine deaminase that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1cc0b8f7fffcb7e99919da6f2e8d33d
https://doi.org/10.1182/blood.v80.3.587.587

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Dependence of cell survival on DNA repair in human mononuclear phagocytes

Autor: C Terai, D B Wasson, C J Carrera, D A Carson

Publikováno v: The Journal of Immunology. 147:4302-4306

Mononuclear phagocytes play a central role in the pathogenesis of chronic inflammatory diseases. It is therefore important to define chemotherapeutically exploitable metabolic pathways that distinguish monocytes from other cell types. Blood monocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4c3110da37c05ed42c0a14bc7372216
https://doi.org/10.4049/jimmunol.147.12.4302

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Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

Autor: D, Genini, S, Adachi, Q, Chao, D W, Rose, C J, Carrera, H B, Cottam, D A, Carson, L M, Leoni

Publikováno v: Blood. 96(10)

Adenine deoxynucleosides induce apoptosis in quiescent lymphocytes and are thus useful drugs for the treatment of indolent lymphoproliferative diseases. To explain why deoxyadenosine and its analogs are toxic to a cell that is not undergoing replicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59d773cab6d0cde8bb23d4c99dc3d721
https://pubmed.ncbi.nlm.nih.gov/11071652

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The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia

Autor: Y, Hori, H, Hori, Y, Yamada, C J, Carrera, M, Tomonaga, S, Kamihira, D A, Carson, T, Nobori

Publikováno v: International journal of cancer. 75(1)

Adult T-cell leukemia (ATL) is a retrovirus-associated leukemia with poor prognosis and often has deletions of the p16INK4a and p15INK4b genes on chromosome 9p21. The gene for methylthioadenosine phosphorylase (MTAP), a purine and methionine metaboli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc9c7482c8c0859dcfcdbe18b1c0a4ee
https://pubmed.ncbi.nlm.nih.gov/9426690

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Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells

Autor: H, Hori, P, Tran, C J, Carrera, Y, Hori, M D, Rosenbach, D A, Carson, T, Nobori

Publikováno v: Cancer research. 56(24)

Methylthioadenosine phosphorylase (MTAP), an enzyme involved in purine and methionine metabolism, is present in all normal tissues but is frequently deficient in a variety of cancers. It has been suggested that this metabolic difference between norma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32fea689ab3d9bdf9d75d5731ff088b5
https://pubmed.ncbi.nlm.nih.gov/8971171

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Oral 2-chlorodeoxyadenosine in psoriatic arthritis. A preliminary report

Autor: B, Eibschutz, S M, Baird, M H, Weisman, D G, Amox, M, Spellman, D, Piacquadio, C J, Carrera, D A, Carson

Publikováno v: Arthritis and rheumatism. 38(11)

To determine if weekly oral 2-chlorodeoxyadenosine (2-CdA) can induce selective lymphocytopenia, and reduce inflammation, in patients with refractory psoriatic arthritis.Seven patients with psoriatic arthritis were treated with oral 2-CdA at weekly d

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https://pubmed.ncbi.nlm.nih.gov/7488281

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Purine metabolism of lymphocytes. Targets for chemotherapy drug development

Autor: C J, Carrera, A, Saven, L D, Piro

Publikováno v: Hematology/oncology clinics of North America. 8(2)

The unique metabolic profile that renders lymphoid cells sensitive to purine deoxynucleosides also accounts for the response of chronic lymphoid malignancies to purine analogues. Consistent with earlier observations in children with adenosine deamina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39ca47ab7c71fc26c7743f19e33b9b76
https://pubmed.ncbi.nlm.nih.gov/8040145

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