Zobrazeno 1 - 10 of 28 pro vyhledávání: '"C J, Blankley"'
1
Identification and Characterization of m1 Selective Muscarinic Receptor Antagonists
Autor: D.W. Moreland, Juan C. Jaen, Penvose-Yi, Roy D. Schwarz, C.E. Augelli-Szafran, C. J. Blankley, Anthony Jerome Thomas, C.B. Nelson
Publikováno v: Journal of Medicinal Chemistry. 42:356-363
A series of esters of 1,4-disubstituted tetrahydropyridine carboxylic acids (I) has been synthesized and characterized as potential m1 selective muscarinic receptor antagonists. The affinity of these compounds for the five human muscarinic receptor s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99ae9fbcb3fa6b3d09c07d2e2341d960
https://doi.org/10.1021/jm980067l
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2
Stigmata: An Algorithm To Determine Structural Commonalities in Diverse Datasets
Autor: D. Weininger, N. E. Shemetulskis, Jeremy J. Yang, C. J. Blankley, C. Humblet
Publikováno v: Journal of Chemical Information and Computer Sciences. 36:862-871
An algorithm, Stigmata, is described, which extracts structural commonalities from chemical datasets. It is discussed using several illustrative examples and a pharmaceutically interesting set of dopamine D2 agonists. The commonalities are determined
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8ed132b98faa79cd6481649226c0bb9
https://doi.org/10.1021/ci950169+
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3
Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents. 8. Incorporation of Amide or Amine Functionalities into a Series of Disubstituted Ureas and Carbamates. Effects on ACAT Inhibition in vitro and Efficacy in vivo
Autor: C. J. Blankley, B.R. Krause, Patrick Michael O'brien, Michael William Wilson, K. L. Hamelehle, R. L. Stanfield, D. R. Sliskovic, Bruce David Roth
Publikováno v: Journal of Medicinal Chemistry. 37:1810-1822
A series of disubstituted ureas containing amide or amine groups was prepared and evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyl transferase in vitro and to lower plasma total cholesterol in a variety of cholesterol-fed rat models
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec94948a126f2e8cc31ae8279ce1bf13
https://doi.org/10.1021/jm00038a010
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4
Inhibitors of acyl-CoA:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents
Autor: T. L. Stoeber, R. L. Stanfield, W. H. Roark, Brian R. Krause, C. J. Blankley, Bharat K. Trivedi, J. A. Picard, Ann Holmes, Essenburg Ad, M. K. Shaw
Publikováno v: Journal of Medicinal Chemistry. 36:3300-3307
We have synthesized a series of N-phenyl-N'-aralkyl and N-phenyl-N'-(1-phenylcycloalkyl)ureas as inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). This intracellular enzyme is thought to be responsible for the esterification of dietary chole
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb799f26eb61cb17cd1f2baa218096d7
https://doi.org/10.1021/jm00074a011
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7
ChemInform Abstract: N6-Substituted Adenosine Receptor Agonists: Potential Antihypertensive Agents
Autor: James A. Bristol, S. A. Johnson, W. J. Kramer, Bharat K. Trivedi, Michael J. Ryan, William C. Patt, Harriet W. Hamilton, D. M. Cohen, C. J. Blankley, Robert F. Bruns
Publikováno v: ChemInform. 22
Adenosine is known to exert a wide range of pharmacological effects including hypotension. This effect of adenosine suggested that modified analogues of adenosine might provide useful antihypertensive agents. Thus, we prepared a series of novel N6-be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9b4ea132471abc6c7fa47aa7863dc10
https://doi.org/10.1002/chin.199127269
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