Zobrazeno 1 - 10 of 65 pro vyhledávání: '"C J, Allegra"'
2
Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen
Autor: J L, Grem, K D, Danenberg, K, Behan, A, Parr, L, Young, P V, Danenberg, D, Nguyen, J, Drake, A, Monks, C J, Allegra
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(4)
To determine the expression of three targets of 5-fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd) in human tumor cell lines and to compare these with the 50% growth inhibition concentrations (GI(50)) from the National Cancer Institute databa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f5ee16211666ce694e780afba250eb51
https://pubmed.ncbi.nlm.nih.gov/11309351
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3
Cell cycle regulation of the G0/G1 transition in 5-fluorouracil-sensitive and -resistant human colon cancer cell lines
Autor: C J, McGinn, B C, Pestalozzi, J C, Drake, M C, Glennon, K, Kunugi, G, Otterson, C J, Allegra, P G, Johnston, T J, Kinsella
Publikováno v: Cancer journal (Sudbury, Mass.). 6(4)
Resistance to 5-fluorouracil (5-FU) has been associated with thymidylate synthase (TS) gene amplification and increased TS protein levels. Increased TS protein expression has also been found to be a significant independent prognostic factor for disea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a30d7956f72ca1eb76d55178773f4fb2
https://pubmed.ncbi.nlm.nih.gov/11038140
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4
Molecular heterogeneity and function of EWS-WT1 fusion transcripts in desmoplastic small round cell tumors
Autor: J, Liu, M M, Nau, J C, Yeh, C J, Allegra, E, Chu, J J, Wright
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(9)
Desmoplastic small round cell tumor (DSRCT) is a primitive sarcoma with a consistent cytogenetic abnormality, t(11;22)(p13;q12). This chromosomal translocation generates a chimeric transcript that is formed by fusion of the 5' region of the Ewing's s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aedc960973a87b012201fcc41444100b
https://pubmed.ncbi.nlm.nih.gov/10999739
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7
A Phase I study of raltitrexed, an antifolate thymidylate synthase inhibitor, in adult patients with advanced solid tumors
Autor: J L, Grem, J M, Sorensen, E, Cullen, C H, Takimoto, S M, Steinberg, A P, Chen, J M, Hamilton, S G, Arbuck, N, McAtee, D, Lawrence, B, Goldspiel, P G, Johnston, C J, Allegra
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(9)
The purpose of this study was to perform a Phase I trial of raltitrexed, a selective inhibitor of thymidylate synthase, and to determine the pharmacokinetic and toxicity profiles as a function of raltitrexed dose. Fifty patients with advanced solid t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::288f06bc6a5369531adcee7a27b4d164
https://pubmed.ncbi.nlm.nih.gov/10499608
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9
Epitope mapping of a series of human thymidylate synthase monoclonal antibodies
Autor: K A, Behan, P G, Johnston, C J, Allegra
Publikováno v: Cancer research. 58(12)
We have reported previously the development and application of several monoclonal antibodies to thymidylate synthase (TS). In this study, we used a series of overlapping 17-mer peptides that spanned the entire TS protein to map the epitope recognized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::636fa9588dd711479c26fdc4065c3d49
https://pubmed.ncbi.nlm.nih.gov/9635586
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10
Modulation of fluorouracil cytotoxicity by interferon-alpha and -gamma
Autor: A, Ismail, C J, Van Groeningen, A, Hardcastle, Q, Ren, G W, Aherne, F, Geoffroy, C J, Allegra, J L, Grem
Publikováno v: Molecular pharmacology. 53(2)
Because interferons (IFN)-alpha and -gamma individually have increased fluorouracil (FUra) cytotoxicity in several in vitro models, we studied the effects of FUra combined with IFN-alpha + gamma in HT29 colon cancer cells. A 96-hr exposure to IFN-alp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d39f3200f9bf69faffe080b22937950a
https://pubmed.ncbi.nlm.nih.gov/9463483
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