Výsledky vyhledávání - "C I Westacott"

Interleukin 1 alpha and beta production by cells isolated from membranes around aseptically loose total joint replacements

Autor: G Taylor, C I Westacott, Christopher J. Elson, R M Atkins

Publikováno v: Annals of the Rheumatic Diseases. 51:638-642

Aseptic loosening of joint prostheses is accompanied by local osteolysis. To determine whether local production of interleukin 1 might contribute to such lysis, the number of interleukin 1 secreting cells in the pseudosynovial membrane surrounding pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156ef9a635549072d6cf576b8349e6c2
https://doi.org/10.1136/ard.51.5.638

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Identification of novel single nucleotide polymorphisms in intron 1B and exon 1C of the human interleukin-1 receptor type I (IL-1RI) gene

Autor: Despina Sitara, O. O. Olomolaiye, LJ Keen, Jeffrey L. Bidwell, H. R. Morse, Christopher J. Elson, C. I. Westacott, N. A. P. Wood

Publikováno v: Genes and immunity. 1(2)

We have identified two novel single nucleotide polymorphisms in the 5' region of the human IL-1RI gene: (1) A-->G at position 52 in intron 1B (GenBank accession number AF146426), which creates an Mspl restriction endonuclease site. Allele frequencies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356303ed2395cf9d2d51825f83fcae93
https://pubmed.ncbi.nlm.nih.gov/11196665

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An MspA1 I polymorphism in exon 1 of the human TNF receptor type I (p55) gene

Autor: S A, Pitts, O O, Olomolaiye, C J, Elson, C I, Westacott, J L, Bidwell

Publikováno v: European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 25(2-3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2a355f38af814eed319a8e675a2fde2
https://pubmed.ncbi.nlm.nih.gov/9615917

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Identification of a rare Bg/II polymorphism in the promoter region of the human TNF receptor type I (p55) gene

Autor: S A, Pitts, O O, Olomolaiye, C J, Elson, C I, Westacott, J L, Bidwell

Publikováno v: European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 25(2-3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff792dd9024dd01bc74338b8f82bed9a
https://pubmed.ncbi.nlm.nih.gov/9615918

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Alteration of cartilage metabolism by cells from osteoarthritic bone

Autor: C I, Westacott, G R, Webb, M G, Warnock, J V, Sims, C J, Elson

Publikováno v: Arthritis and rheumatism. 40(7)

To determine whether bone cells alter cartilage metabolism.Bone cell cultures were established using explants obtained from the hip and knee joints of 9 patients with osteoarthritis (OA) and 6 subjects without arthritis (nonarthritic [NA]). NA human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::556b8403c224baae57782e9d36595b06
https://pubmed.ncbi.nlm.nih.gov/9214429

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Tumor necrosis factor-alpha receptor expression on chondrocytes isolated from human articular cartilage

Autor: C I, Westacott, R M, Atkins, P A, Dieppe, C J, Elson

Publikováno v: The Journal of rheumatology. 21(9)

To determine whether the previously observed enhanced susceptibility of osteoarthritic (OA) cartilage to tumor necrosis factor-alpha (TNF-alpha) induced degradation could be due to differences in receptor expression.Using specific monoclonal antibodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::962483a3f50b7d776b9e55e7ab890a4b
https://pubmed.ncbi.nlm.nih.gov/7799355

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Mediators of joint swelling and damage in rheumatoid arthritis and pristane induced arthritis

Autor: Christopher J. Elson, K. D. Bhoola, Stephen J. Thompson, C. I. Westacott

Publikováno v: Autoimmunity. 13(4)

Joint swelling and tenderness in rheumatoid arthritis (RA) probably result from IgG aggregates activating complement with the consequent attraction of polymorphonuclear leucocytes (PMNs) and the liberation of their granule enzymes such as kininogenas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a850942502b1de630cfa67b959acc637
https://pubmed.ncbi.nlm.nih.gov/1472643

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The acute phase response

Autor: C. I. Westacott, J. T. Whicher

Publikováno v: Biochemistry of Inflammation ISBN: 9789401053327

Inflammation comprises a series of cellular phagocytosis and either the killing of microorganisms or the digestion of cell debris. This is followed by proliferation of connective tissue cells and repair of the intercellular matrix. Both of these even

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d548a64164ba3601f75129702e735ef6
https://doi.org/10.1007/978-94-011-2996-1_13

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Synovial fluid concentration of five different cytokines in rheumatic diseases

Autor: J.T. Whicher, C I Westacott, I C Barnes, A Swan, Paul Dieppe, D Thompson

Interleukin-1 beta, interleukin-2, tumour necrosis factor alpha, and the interferons, alfa and gamma, were measured concurrently in synovial fluid samples from 68 patients with rheumatic diseases. Mean interleukin-1 beta concentrations (130.3 (SD 22)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6c0eb265465a47eeb1ed858e72539f
https://europepmc.org/articles/PMC1004202/

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