Zobrazeno 1 - 10
of 73
pro vyhledávání: '"C I, Civin"'
Autor:
Harry L. Malech, Thomas Foster City Dull, Sebastian Brenner, C. I. Civin, Joachim Roesler, Michael C. Kelly, Narda L. Whiting-Theobald, Anatoly Bukovsky
Publikováno v:
Blood. 100:4381-4390
HIV-1-derived lentivectors are promising for gene transfer into hematopoietic stem cells but require preclinical in vivo evaluation relevant to specific human diseases. Nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice accept human he
Autor:
L C Strauss, B G Leventhal, Moody D. Wharam, R L Dubowy, Michael L. Graham, C I Civin, A M Yeager, C A Hurwitz, P M Colombani, Joseph Wiley
Publikováno v:
Journal of Clinical Oncology. 10:1857-1864
PURPOSE The purpose of this study was to determine the toxicities of and responses to high-dose busulfan and cyclophosphamide with autologous bone marrow transplant (ABMT) in patients with recurrent or refractory pediatric solid tumors. PATIENTS AND
Publikováno v:
Journal of Biological Chemistry. 267:17540-17546
CD34 is a transmembrane sialoglycoprotein expressed by early hematopoietic progenitor cells as well as endothelial cells. Previously we found that CD34 is rapidly and stoichiometrically phosphorylated by activated protein kinase C (PKC) (Fackler, M.J
Publikováno v:
Blood. 77:1681-1690
To compare the differentiation of early B- and T-lymphoid precursors, we have used immune adherence combined with analytical flow cytometric techniques to enrich and characterize subsets of the small population of bone marrow mononuclear cells that e
Publikováno v:
Journal of Biological Chemistry. 265:11056-11061
The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. We found that CD34 is a phosphoprotein and therefore examined the regulation of its phosphorylation. Activation of protein kinase C
Publikováno v:
Journal of Cellular Physiology. 142:219-230
To facilitate the direct study of the molecular events that control the development of human burst-forming units-erythroid (BFU-E), we have developed a method to purify BFU-E from peripheral blood. Using density centrifugation, rosetting with a mixtu
Publikováno v:
Humanexperimental toxicology. 23(4)
Haematopoietic suppression is one of the dose-limiting side effects of chronic zidovudine (AZT) therapy. We tested the hypothesis that AZT would reduce mitochondrial DNA (mtDNA) content in haematopoietic progenitors causing impaired haematopoiesis an
Publikováno v:
Transplantation. 68(5)
We sought to compare the immunoreactive potential of human cord blood (CB) versus normal adult bone marrow (BM) versus mobilized blood (peripheral blood stem cells; PBSC) from cancer patients.Forty mice were randomized to receive a range of doses of
Publikováno v:
Experimental hematology. 27(2)
The identification and study of genes expressed in hematopoietic stem/progenitor cells should further our understanding of hematopoiesis. Transcription factors in particular are likely to play important roles in maintaining the set of genes that defi
Publikováno v:
Blood. 92(11)
CBFbeta-SMMHC is expressed in M4Eo acute myeloid leukemia (AML) as a result of inv(16), but how it contributes to leukemogenesis is unknown. p53 mutations are rare in de novo AML, but they are common in many malignancies. Expression of CBFbeta-SMMHC