Zobrazeno 1 - 10 of 236 pro vyhledávání: '"C Hanski"'
1
UDCA slows down intestinal cell proliferation by inducing high and sustained ERK phosphorylation
Autor: Martin Zeitz, C. Hanski, G. Pagès, M.L. Hanski, B. Choudhary, Christoph Loddenkemper, S Krishna-Subramanian
Publikováno v: International Journal of Cancer. 130:2771-2782
Ursodeoxycholic acid (UDCA) attenuates colon carcinogenesis in humans and in animal models by an unknown mechanism. We investigated UDCA effects on normal intestinal epithelium in vivo and in vitro to identify the potential chemopreventive mechanism.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a72c80e57cdf61034da23461d9dd57
https://doi.org/10.1002/ijc.26336
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5
The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-xL protein
Autor: M. Bhonde, Kimitoshi Kohno, Peter T. Daniel, Dhatchana Moorthy, M.L. Hanski, Antje Müller, C. Hanski, Roberta Magrini, Martin Zeitz, Edward A. Sausville, Peter Wiegand
Publikováno v: Oncogene. 24:148-156
The broad-range cyclin-dependent kinase inhibitor 7-hydroxystaurosporine (UCN-01) is known to induce both a G1 cell cycle arrest and apoptosis. The mechanism of UCN-01-induced apoptosis is largely unknown. We analysed the mechanism of cytotoxicity of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad103a29696ef7c427df3cc81201b275
https://doi.org/10.1038/sj.onc.1207842
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6
Histopathological Subtypes and Prognosis of Gastric Cancer Are Correlated with the Expression of Mucin-Associated Sialylated Antigens: Sialosyl-Lewisa, Sialosyl-Lewisx and Sialosyl-Tn
Autor: K Rafiqpoor, Franz-Georg Hanisch, C Hanski, E. Monaca, S Engel, H. Pichlmaier, Stephan Baldus, Stefan P. Mönig, Juergen Thiele, T. K. Zirbes, Hans-Peter Dienes
Publikováno v: Tumor Biology. 19:445-453
The expression of three sialylated mucin-associated antigens - sialosyl-Lewisa (SLEA), sialosyl-Lewisx (SLEX) and sialosyl-Tn (STN) - and their correlation with the TNM stage, histopathological growth pattern and prognosis was investigated in a serie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a0de62c31ebf94eda285e1f242ff4f8
https://doi.org/10.1159/000030036
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7
Differential stimulation of intestinal mucin secretion by cholera toxin and carbachol
Autor: Ernst-Otto Riecken, K. M. Kreusel, Michael Fromm, Hans-Jörg Epple, Jörg-Dieter Schulzke, C. Hanski
Publikováno v: Pfl�gers Archiv European Journal of Physiology. 433:638-647
Cholinergic stimulation triggers the secretion of apically stored, preformed mucin from goblet cells but the pathway of cAMP-stimulated mucin secretion is not known. In this study the effect of cholera toxin on mucin secretion in the human colonic go
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b8e40a3490a78b49f0767459796c9c
https://doi.org/10.1007/s004240050325
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8
Is mucinous carcinoma of the colorectum a distinct genetic entity?
Autor: C Hanski
Publikováno v: British Journal of Cancer
Mucinous carcinomas are defined on the basis of the amount of the mucus component in the tumour mass. Apart from this quantitative criterion, a number of clinicopathological parameters (such as localisation, prevalence in different countries and age
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f94cfd7daf2e4d47642e053efa06c1
https://doi.org/10.1038/bjc.1995.514
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9
The chemopreventive agent ursodeoxycholic acid inhibits proliferation of colon carcinoma cells by suppressing c-Myc expression
Autor: Marie-Luise Hanski, C. Hanski, Martin Zeitz, Santosh Krishna-Subramanian, Roser Peiró-Jordán, Juliane Lüscher-Firzlaff
Publikováno v: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 21(5)
Ursodeoxycholic acid (UDCA) can prevent chemical and colitis-associated colon carcinogenesis by unknown mechanism(s). One of the processes underlying the chemopreventive action could be the inhibition of proliferation by UDCA. To clarify the antiprol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0b59ce7dd23df89370432d0ee8838c
https://pubmed.ncbi.nlm.nih.gov/22395148
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10
Proliferation rate but not mismatch repair affects the long-term response of colon carcinoma cells to 5FU treatment
Autor: B. Choudhary, C. Hanski, M.L. Hanski, Martin Zeitz
Publikováno v: Cancer letters. 320(1)
The role of mismatch repair (MMR) in the response of colon carcinoma cells to 5-fluorouracil (5FU) is not well understood. In most of the in vitro studies only short-term response was investigated. We focussed here on the influence of MMR status on t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2727d557257f6660111c3183b7f62ce8
https://pubmed.ncbi.nlm.nih.gov/22266192
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