Zobrazeno 1 - 9 of 9 pro vyhledávání: '"C H, Wortel"'
1
Safety and tolerability of antagonist anti-human CD40 Mab ch5D12 in patients with moderate to severe Crohn's disease
Autor: Paul Rutgeerts, C H Wortel, Jan Ceuppens, Eran Goldin, Mark De Boer, Louis Boon, Karel Geboes, R A Hogezand, Ahmad Kasran, Stefan Schreiber
Publikováno v: Alimentary Pharmacology and Therapeutics. 22:111-122
Summary Background: The ligation of CD40 by CD154 is a critical step in the interaction between APC and T cells. In animals, antagonizing CD40L-CD40 has been shown to reduce the severity of several autoimmune and inflammatory disorders, including exp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2ee0f3f5df01371b38cf976dae69d3
https://doi.org/10.1111/j.1365-2036.2005.02526.x
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2
Activation of coagulation after administration of tumor necrosis factor to normal subjects
Autor: J W ten Cate, H. R. Büller, C. H. Wortel, H. ten Cate, C. E. Hack, T. van der Poll, S. J. H. Van Deventer, Kenneth A. Bauer, Robert D. Rosenberg, H. P. Sauerwein
Publikováno v: New England journal of medicine, 322(23), 1622-1627. Massachussetts Medical Society
Tumor necrosis factor has been implicated in the activation of blood coagulation in septicemia, a condition commonly associated with intravascular coagulation and disturbances of hemostasis. To evaluate the early dynamics and the route of the in vivo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2150fa860eec4dc168babe71fec1355e
https://doi.org/10.1056/nejm199006073222302
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3
Neutrophils and neutrophil-endothelial cell adhesion in adult respiratory distress syndrome
Autor: C H, Wortel, C M, Doerschuk
Publikováno v: New horizons (Baltimore, Md.). 1(4)
The neutrophil has been implicated as a pivotal player in the pathogenesis of adult respiratory distress syndrome (ARDS) and multiple organ failure. An important first step in the process of neutrophil-mediated organ injury involves the binding of ne
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::61bb53ee7f46cf379aa193e00f3e7437
https://pubmed.ncbi.nlm.nih.gov/7916259
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4
Interleukin-6 mediates host defense responses induced by abdominal surgery
Autor: C H, Wortel, S J, van Deventer, L A, Aarden, N J, Lygidakis, H R, Büller, F J, Hoek, J, Horikx, J W, ten Cate
Publikováno v: Surgery. 114(3)
Cytokines have been implicated as pivotal mediators of the host defense reaction. In patients undergoing surgery we investigated the relationship between such mediators and postoperative host defense responses.Tumor necrosis factor (TNF) was determin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f00e242de2614c33f2c9bf48088f41d5
https://pubmed.ncbi.nlm.nih.gov/7690162
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5
Immunotherapy with Human Antiendotoxin Antibodies in the Treatment of Gram-Negative Sepsis: Practical Considerations
Autor: C. H. Wortel
Publikováno v: Host Defense Dysfunction in Trauma, Shock and Sepsis ISBN: 9783642774072
Gram-negative sepsis is an increasingly common disease, with a high mortality rate [1]. Endotoxin, present in the outer membrane of all gram-negative bacteria, is an important trigger in the development of the septic syndrome [2]. Recently, a multice
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::033847ba8f042a4d9f37e75dacb9c9b9
https://doi.org/10.1007/978-3-642-77405-8_157
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6
Effectiveness of a human monoclonal anti-endotoxin antibody (HA-1A) in gram-negative sepsis: relationship to endotoxin and cytokine levels
Autor: C. R. Smith, Isabel E. Allen, M. J. Lubbers, C. H. Wortel, S. J. H. Van Deventer, C. L. Sprung, M. Jastremski, J W ten Cate, M. A. M. Van Der Möhlen
Publikováno v: Journal of infectious diseases, 166(6), 1367-1374. Oxford University Press
Gram-negative sepsis is caused by endotoxin-induced release of tumor necrosis factor (TNF) and other cytokines. HA-1A is a human monoclonal antibody that binds specifically to endotoxin. HA-1A should prevent death in endotoxemic patients and reduce s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28276c58513cc7f358b83254048f61a0
https://pubmed.ncbi.nlm.nih.gov/8515123
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7
Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group
Autor: E J, Ziegler, C J, Fisher, C L, Sprung, R C, Straube, J C, Sadoff, G E, Foulke, C H, Wortel, M P, Fink, R P, Dellinger, N N, Teng
Publikováno v: The New England journal of medicine. 324(7)
HA-1A is a human monoclonal IgM antibody that binds specifically to the lipid A domain of endotoxin and prevents death in laboratory animals with gram-negative bacteremia and endotoxemia.To evaluate the efficacy and safety of HA-1A, we conducted a ra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b63161fa58efc2081f25a0adba1ba4bf
https://pubmed.ncbi.nlm.nih.gov/2057029
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9
Detection and clinical relevance of human endotoxemia
Autor: A, Sturk, S J, van Deventer, C H, Wortel, J H, Levels, J W, ten Cate, H R, Büller, G T, Sanders
Publikováno v: Zeitschrift fur medizinische Laboratoriumsdiagnostik. 31(3)
An optimized chromogenic assay for the detection of endotoxins in human blood is described. The assay comprises the removal of the inhibitory activity of plasma components by a dilution plus heating procedure, endotoxin-dependent activation of Limulu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49759585028f9c62d5756e5b24c13c7b
https://pubmed.ncbi.nlm.nih.gov/2368470
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