Zobrazeno 1 - 10
of 13
pro vyhledávání: '"C H, Pletcher"'
Autor:
M S, Gee, C J, Koch, S M, Evans, W T, Jenkins, C H, Pletcher, J S, Moore, H K, Koblish, J, Lee, E M, Lord, G, Trinchieri, W M, Lee
Publikováno v:
Cancer research. 59(19)
The role of angiogenesis inhibition in the antitumor activity of recombinant murine interleukin 12 (rmIL-12) was studied in K1735 murine melanomas, the growth of which is rapidly and markedly suppressed by rmIL-12 treatment. On the basis of the predi
Publikováno v:
Cytometry. 32(1)
Apoptosis is a vital process for organism development and, when disrupted, can lead to abnormalities including cancer and autoimmune diseases. We demonstrate a novel multicolor flow cytometry approach for quantifying apoptosis and cell cycle informat
Publikováno v:
Cytometry. 29(1)
The importance of glutathione (GSH) in contributing to cancer therapy resistance is well established. Various advantages may accrue from the ability to determine the distribution of GSH content in individual tumor cells disaggregated from solid tumor
Publikováno v:
Blood. 86(6)
To determine the potential role of autocrine growth factor production in regulating primitive human hematopoietic cell development, we examined highly purified CD34+, c-Kit+ marrow mononuclear cells for expression of c-Kit ligand (KL) and stem cell t
Publikováno v:
The Journal of biological chemistry. 267(6)
Inhibitory effects of human immunodeficiency virus (HIV) on T lymphocyte function have been linked to perturbation of signaling through the T cell antigen receptor-CD3 complex. Comparative biochemical analyses of signaling responses were performed in
Publikováno v:
Scopus-Elsevier
Naturally occurring isolates of human immunodeficiency virus (HIV) have been described which are deficient in their ability to fuse with and kill CD4+ target cells. Although the molecular basis for their attenuation has not yet been defined, several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e26c2bd59ed3bcd03507902f340b39
https://europepmc.org/articles/PMC248977/
https://europepmc.org/articles/PMC248977/
Autor:
C H Pletcher, G L Nelsestuen
Publikováno v:
Journal of Biological Chemistry. 257:5342-5345
The heparin-catalyzed inactivation of thrombin by antithrombin was examined using saturation kinetics and fractional reaction lifetimes. Based solely on kinetic analysis, the reaction binding sequence was determined to be heparin binding to antithrom
Publikováno v:
Journal of Biological Chemistry. 255:7433-7438
The carbohydrate portion of prothrombin fragment 1 has been removed by fluorolysis in anhydrous HF. The deglycosylated protein retains its calcium- and membrane-binding properties. The slow, calcium-dependent protein transition monitored by changes i
Autor:
G L Nelsestuen, C H Pletcher
Publikováno v:
Journal of Biological Chemistry. 258:1086-1091
The kinetics of the heparin-dependent antithrombin/protease reaction were consistent with an ordered sequential two-substrate reaction model under all circumstances tested. In this model, heparin is the catalyst; while antithrombin is the first subst
Autor:
C H, Pletcher, G L, Nelsestuen
Publikováno v:
The Journal of biological chemistry. 258(2)
The kinetics of the heparin-dependent antithrombin/protease reaction were consistent with an ordered sequential two-substrate reaction model under all circumstances tested. In this model, heparin is the catalyst; while antithrombin is the first subst