Výsledky vyhledávání - "C H, MacPhee"

Granulocyte/macrophage colony-stimulating factor affects myo-inositol metabolism in a novel manner. Implications for its priming action on human neutrophils

Autor: C H MacPhee

Publikováno v: Biochemical Journal. 286:535-540

Little is known about the signal transduction processes involved in the priming action of granulocyte/macrophage colony-stimulating factor (GM-CSF) on neutrophils. This study has used myo-[3H]inositol-labelled human neutrophils to determine whether p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba9a9528cfc6cb14cf790e8da79f70f
https://doi.org/10.1042/bj2860535

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Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group

Autor: C J, Packard, D S, O'Reilly, M J, Caslake, A D, McMahon, I, Ford, J, Cooney, C H, Macphee, K E, Suckling, M, Krishna, F E, Wilkinson, A, Rumley, G D, Lowe

Publikováno v: The New England journal of medicine. 343(16)

Chronic inflammation is believed to increase the risk of coronary events by making atherosclerotic plaques in coronary vessels prone to rupture. We examined blood constituents potentially affected by inflammation as predictors of risk in men with hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f2dd743d020cc2a78b1eaed802d41c3
https://pubmed.ncbi.nlm.nih.gov/11036126

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Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor

Autor: C H, MacPhee, K E, Moores, H F, Boyd, D, Dhanak, R J, Ife, C A, Leach, D S, Leake, K J, Milliner, R A, Patterson, K E, Suckling, D G, Tew, D M, Hickey

Publikováno v: The Biochemical journal. 338

A novel and potent azetidinone inhibitor of the lipoprotein-associated phospholipase A2 (Lp-PLA2), i.e. platelet-activating factor acetylhydrolase, is described for the first time. This inhibitor, SB-222657 (Ki=40+/-3 nM, kobs/[I]=6. 6x10(5) M-1.s-1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::626460f359a74e1b15f305f443280f4d
https://pubmed.ncbi.nlm.nih.gov/10024526

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Identification of a truncated form of the CC chemokine CK beta-8 demonstrating greatly enhanced biological activity

Autor: C H, Macphee, E R, Appelbaum, K, Johanson, K E, Moores, C S, Imburgia, J, Fornwald, T, Berkhout, M, Brawner, P H, Groot, K, O'Donnell, D, O'Shannessy, G, Scott, J R, White

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(11)

A new CC chemokine, designated CKbeta-8 or myeloid progenitor inhibitor factor-1, was recently identified in a large scale sequencing effort and was cloned from a human aortic endothelial library. CKbeta-8 cDNA encodes a signal sequence of 21 amino a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f4cc6014e97c593c660b01f0e6617a5
https://pubmed.ncbi.nlm.nih.gov/9834116

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Involvement of calcium in modulation of neutrophil function by phorbol esters that activate protein kinase C isotypes and related enzymes

Autor: Janet E. Merritt, Fred J. Evans, Kitty E. Moores, C H MacPhee, Pankaj Sharma, A.T. Evans

In this study, the effects of a series of phorbol esters with different spectra of biological activities and different patterns of activation of the isoenzymes of protein kinase C (PKC) have been studied in human neutrophils. The aim was to gain more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669407c485d381920e12165a30597b57
https://europepmc.org/articles/PMC1132263/

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The stereoselective recognition of substrates by phosphoinositide kinases. Studies using synthetic stereoisomers of dipalmitoyl phosphatidylinositol

Autor: C H, Macphee, A N, Carter, F, Ruiz-Larrea, J G, Ward, R C, Young, C P, Downes

Publikováno v: The Journal of biological chemistry. 267(16)

Soluble phosphatidylinositol (PtdIns) 4- and 3-kinase activities were partially purified and characterized from human placental extracts. The placental PtdIns 4-kinase (type 3) has a Km for ATP of 460 microM and is kinetically different to a partiall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b916248c30a14786816251e43fcf9c92
https://pubmed.ncbi.nlm.nih.gov/1317855

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Thyrotropin-releasing hormone-stimulated [3H]inositol metabolism in GH3 pituitary tumor cells. Studies with lithium

Autor: A H, Drummond, M, Bushfield, C H, Macphee

Publikováno v: Molecular pharmacology. 25(2)

GH3 pituitary tumor cells were labeled to isotopic equilibrium with [3H]inositol. Thyrotropin-releasing hormone (TRH), which has been shown to stimulate inositol phospholipid metabolism in these cells, enhanced the accumulation of [3H]inositol-derive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c46e27d665c10cfad7a9bf866ff993c
https://pubmed.ncbi.nlm.nih.gov/6321943

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Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets

Autor: C H, Macphee, D H, Reifsnyder, T A, Moore, K M, Lerea, J A, Beavo

Publikováno v: The Journal of biological chemistry. 263(21)

Agents such as prostaglandins E1 and I2 which elevate cAMP levels in platelets also increase cAMP phosphodiesterase activity. Since much of the cAMP phosphodiesterase activity in human platelets is due to the cGMP-inhibited isozyme (Macphee, C. H., H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d45ffdf15de487eb981ba48186325d8
https://pubmed.ncbi.nlm.nih.gov/2839485

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