Výsledky vyhledávání - "C H, Gemmell"

Assessment of material-induced procoagulant activity by a modified Russell viper venom coagulation time test

Autor: C H, Gemmell

Publikováno v: Journal of biomedical materials research. 42(4)

Platelet activation is an inevitable consequence of blood-material interactions. The ability of those activated platelets and platelet-derived microparticles to enhance coagulation reactions leading to thrombin/fibrin formation has not been well stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c42a84c2ac53aaa2c6b5b32934b5993
https://pubmed.ncbi.nlm.nih.gov/9827686

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Ethanol inhibits thrombin-induced secretion of the contents of human platelet dense and alpha-granules and lysosomes

Autor: A, Nguyen, C H, Gemmell, E L, Yeo, M A, Packham, M L, Rand

Publikováno v: Thrombosis and haemostasis. 80(4)

Moderate consumption of alcoholic beverages is associated with a reduction in thromboembolic complications of coronary artery disease, possibly partially attributable to inhibition by ethanol of platelet responses to some aggregating agents. Although

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5bdc030387cbb3bbde963fa21378297
https://pubmed.ncbi.nlm.nih.gov/9798988

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A flow cytometric immunoassay to quantify adsorption of complement activation products (iC3b, C3d, SC5b-9) on artificial surfaces

Autor: C H, Gemmell

Publikováno v: Journal of biomedical materials research. 37(4)

Crosslinked agarose microspheres and various polystyrene microspheres were analyzed for complement components after incubation with serum at 37 degrees C for times up to 2 h. Quantification involved direct flow cytometric analysis of the beads after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f76f5c3f8e63eadd48994050b421c1d
https://pubmed.ncbi.nlm.nih.gov/9407295

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Flow cytometric analysis of material-induced platelet activation in a canine model: elevated microparticle levels and reduced platelet life span

Autor: C H, Gemmell, E L, Yeo, M V, Sefton

Publikováno v: Journal of biomedical materials research. 37(2)

Assessment of material-induced platelet activation is important given that it is thought to be a major mechanism of biomaterials thrombogenicity. We monitored, by flow cytometry, platelet microparticle (MP) levels in the circulation during the connec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8349042aa924a76b6773e905bd0ac18f
https://pubmed.ncbi.nlm.nih.gov/9358309

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Material-induced up-regulation of leukocyte CD11b during whole blood contact: material differences and a role for complement

Autor: C H, Gemmell, J P, Black, E L, Yeo, M V, Sefton

Publikováno v: Journal of biomedical materials research. 32(1)

Material-induced thrombogenicity is in part a consequence of leukocyte activation. To evaluate and compare material-induced platelet damage, we have expanded our in vitro flow cytometric immunoassay to include assessment of leukocyte activation. We h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18c624a220c89592b53a1c24065a2622
https://pubmed.ncbi.nlm.nih.gov/8864870

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Conditions influencing release of granule contents from human platelets in citrated plasma induced by ADP or the thrombin receptor activating peptide SFLLRN: direct measurement of percent release of beta-thromboglobulin and assessment by flow cytometry of P-selectin expression

Autor: M L, Rand, D W, Perry, M A, Packham, C H, Gemmell, E L, Yeo, R L, Kinlough-Rathbone

Publikováno v: American journal of hematology. 52(4)

Contrary to a recent report [Rinder et al.: Blood 82:505, 1993], aspirin does inhibit the release of alpha-granule contents as well as inhibiting the release of dense granule contents by human platelets during ADP-induced aggregation in citrated plat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bace0d574e3428d0096972b1f1daf343
https://pubmed.ncbi.nlm.nih.gov/8701947

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Elevated platelet-derived microparticle levels during unstable angina

Autor: N, Singh, C H, Gemmell, P A, Daly, E L, Yeo

Publikováno v: The Canadian journal of cardiology. 11(11)

To use fluorescent-activated flow cytometry coupled with activation-dependent and -independent platelet-specific monoclonal antibodies in a pilot study to assess the degree and time course of platelet activation events in patients presenting within 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f74e66af43d2ae254b84f92227e13be
https://pubmed.ncbi.nlm.nih.gov/8542543

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Platelet activation in whole blood by artificial surfaces: identification of platelet-derived microparticles and activated platelet binding to leukocytes as material-induced activation events

Autor: C H, Gemmell, S M, Ramirez, E L, Yeo, M V, Sefton

Publikováno v: The Journal of laboratory and clinical medicine. 125(2)

Because the lack of thromboresistant vascular biomaterials is in part due to platelet activation, we have attempted, by using fluorescence-activated flow cytometry, to fully characterize the platelet population after in vitro material contact with wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4654a5e3f0a3461f84e66ece4f3c02da
https://pubmed.ncbi.nlm.nih.gov/7531214

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Platelet-derived microparticle formation involves glycoprotein IIb-IIIa. Inhibition by RGDS and a Glanzmann's thrombasthenia defect

Autor: C H, Gemmell, M V, Sefton, E L, Yeo

Publikováno v: The Journal of biological chemistry. 268(20)

While the physiologic role of platelet microparticles may include a stable, physical dispersion of concentrated surface procoagulant activity the mechanism(s) of platelet vesiculation remains unknown. We demonstrate using flow cytometric methods a ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8fa5e42020827a274359ce74c87a297a
https://pubmed.ncbi.nlm.nih.gov/8325838

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