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Akademický článek

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Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest

Autor: Brad E. Hoffman, Da Liebermann, Antonio Giordano, A. De Luca, Muthu Selvakumaran, C Guillouf, Xavier Graña

Publikováno v: Scopus-Elsevier
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Employing the myeloblastic leukemia M1 cell line, which does not express endogenous p53, and genetically engineered variants, it was recently shown that activation of p53, using a p53 temperature-sensitive mutant transgene (p53ts), resulted in rapid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502a560894691b9e48b65e1cfcc2596a
https://doi.org/10.1182/blood.v85.10.2691.bloodjournal85102691

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Akademický článek

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Role of a mutant p53 protein in apoptosis: characterization of a function independent of transcriptional trans-activation

Autor: F Rosselli, Brad E. Hoffman, C Guillouf, R T Sjin, Dan A. Liebermann, E Moustacchi

Publikováno v: International journal of oncology. 13(1)

Wild-type (wt) tumor suppressor p53 has been implicated in cellular radiosensitivity, mediated by its role in apoptosis and growth arrest. Intriguingly, it was observed that the temperature sensitive (ts) mutant p53val135 protein functions as a posit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7cda74dc6ca2ec5610894ab6d5f8c5c
https://pubmed.ncbi.nlm.nih.gov/9625811

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Deregulated apoptosis is a hallmark of the Fanconi anemia syndrome

Autor: A, Ridet, C, Guillouf, E, Duchaud, E, Cundari, M, Fiore, E, Moustacchi, F, Rosselli

Publikováno v: Cancer research. 57(9)

Fanconi anemia (FA) is a genetic human disorder associated with bone marrow failure and predisposition to cancer. FA cells show poor growth capacity and spontaneous chromosomal anomalies as well as cellular and chromosomal hypersensitivity to DNA cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b4a09527703cb7fefc468a07b1e0134
https://pubmed.ncbi.nlm.nih.gov/9135015

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p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis

Autor: C, Guillouf, F, Rosselli, K, Krishnaraju, E, Moustacchi, B, Hoffman, D A, Liebermann

Publikováno v: Oncogene. 10(11)

DNA damage in proliferating mammalian cells induces a complex cellular response comprising perturbation of the cell cycle and programmed cell death. The relationship between p53-dependent and p53-independent apoptotic cell death, as well as the cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15b65f7473c32796c2b9a14d2a95a097
https://pubmed.ncbi.nlm.nih.gov/7784074

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Hypomutability in Fanconi anemia cells is associated with increased deletion frequency at the HPRT locus

Autor: C Guillouf, D Papadopoulo, E Moustacchi, H Mohrenweiser

Fanconi anemia (FA) is an inherited human disorder associated with a predisposition to cancer and characterized by anomalies in the processing of DNA cross-links and certain monoadducts. We reported previously that the frequency of psoralen-photoindu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da94f6bc17c6b0573a8bf04c48f2cccb
https://europepmc.org/articles/PMC54960/

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Fanconi's anemia: genetic and molecular aspects of the defect

Autor: E, Moustacchi, C, Guillouf, D, Fraser, F, Rosselli, C, Diatloff-Zito, D, Papadopoulo

Publikováno v: Nouvelle revue francaise d'hematologie. 32(6)

Several features of Fanconi's anemia (FA) are reported: relative inefficiency in the processing of DNA cross-links and monoadducts, hypomutability at the two loci analysed, complementation of the cytogenetic defect by cocultivation with mouse cells a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::109eb60fe63c3e186df0cfdc49ed452e
https://pubmed.ncbi.nlm.nih.gov/2101869

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