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Emergence of a Specific Intrapulmonary CD4+ T Cell Subset Prior to the Onset of Lung Allograft Dysfunction

Autor: Tereza Martinu, Shaf Keshavjee, Jonathan C. Yeung, Ricardo Zamel, Stephen C. Juvet, C. Guidos, S. Moshkelgosha, Liran Levy

Publikováno v: The Journal of Heart and Lung Transplantation. 38:S17

Purpose We have applied cutting-edge mass cytometry (MC) technology to serial bronchoalveolar lavage (BAL) cells obtained from lung transplant recipients (LTRs) and have used it to compare the cellular composition of the BAL compartment in patients w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d43f42f5af5fdfbb4911e1ae4932a72e
https://doi.org/10.1016/j.healun.2019.01.026

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Akademický článek

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Characterization of preneoplastic thymocytes and of their neoplastic progression in irradiated C57BL/Ka mice

Autor: A Sen-Majumdar, C Guidos, T Kina, M Lieberman, I L Weissman

Publikováno v: The Journal of Immunology. 153:1581-1592

Mice that receive whole body split-dose irradiation develop thymic lymphomas after a long latent period. Before emergence of frank lymphomas, preneoplastic thymocytes, which are defined by their ability to progress to full malignancy on intrathymic t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbfd6932e5b5858a150b9e2df9abc191
https://doi.org/10.4049/jimmunol.153.4.1581

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IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis

Autor: Ronald A. DePinho, A. Ma, Frederick W. Alt, K. Zimmerman, Irving L. Weissman, Peter E. Fisher, T. Moroy, A. Tesfaye, C. Guidos

Publikováno v: The EMBO Journal. 9:3659-3666

Transgenic constructs containing the murine L-myc gene under the control of the immunoglobulin transcriptional enhancer element (Emu) are expressed at unexpectedly high levels in thymocytes and proliferating T cells compared with cells from bone marr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f251be63357eb9501a02beb3cc7aaef
https://doi.org/10.1002/j.1460-2075.1990.tb07577.x

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Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor

Autor: Gerald R. Crabtree, C Guidos, Cornelis L. Verweij

Publikováno v: Journal of Biological Chemistry. 265:15788-15795

Nuclear factor of activated T-cells (NFAT-1) is a transcription factor which is considered to be an important regulator in early T-cell activation. We have developed a system to monitor the transcriptional activity of NFAT-1 at the single cell level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18fae70e832e5eb0e434d7812f72faf9
https://doi.org/10.1016/s0021-9258(18)55467-3

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Characterization of a rat monoclonal antibody specific for a determinant encoded by the V beta 7 gene segment. Depletion of V beta 7+ T cells in mice with Mls-1a haplotype

Autor: C Y Okada, B Holzmann, C Guidos, E Palmer, I L Weissman

Publikováno v: The Journal of Immunology. 144:3473-3477

We have generated a rat mAb, TR310, which recognizes a determinant encoded by the murine V beta 7 gene segment of the TCR. TR310 immunoprecipitates TCR from cell lysates, co-modulates with CD3, and can be used for immunofluorescence staining of T cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a020f0f4256ff81c5eb2da6357c730dd
https://doi.org/10.4049/jimmunol.144.9.3473

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Growth-promoting activity of IL-1 alpha, IL-6, and tumor necrosis factor-alpha in combination with IL-2, IL-4, or IL-7 on murine thymocytes. Differential effects on CD4/CD8 subsets and on CD3+/CD3- double-negative thymocytes

Autor: T Suda, R Murray, C Guidos, A Zlotnik

Publikováno v: The Journal of Immunology. 144:3039-3045

Many cytokines (including IL-1, IL-2, IL-4, IL-6, and TNF-alpha) have been shown to induce thymocyte proliferation in the presence of PHA. In this report, we demonstrate that certain cytokine combinations induce thymocyte proliferation in the absence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a6ac1e33ceceb1fd060558ac31cda17
https://doi.org/10.4049/jimmunol.144.8.3039

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