Zobrazeno 1 - 10
of 132
pro vyhledávání: '"C Glenn, Begley"'
Autor:
Manoj M. Lalu, Joshua Montroy, C. Glenn Begley, Tania Bubela, Victoria Hunniford, David Ripsman, Neil Wesch, Jonathan Kimmelman, Malcolm Macleod, David Moher, Alvin Tieu, Lindsey Sikora, Dean A. Fergusson
Publikováno v:
F1000Research, Vol 9 (2020)
Background: The process of translating preclinical findings into a clinical setting takes decades. Previous studies have suggested that only 5-10% of the most promising preclinical studies are successfully translated into viable clinical applications
Externí odkaz:
https://doaj.org/article/155b2a30cc264c8b84c33f9e7854ebbb
Autor:
Jan L.A. Voskuil, Anita Bandrowski, C. Glenn Begley, Andrew R.M. Bradbury, Andrew D. Chalmers, Aldrin V. Gomes, Travis Hardcastle, Fridtjof Lund-Johansen, Andreas Plückthun, Giovanna Roncador, Alejandra Solache, Michael J. Taussig, James S. Trimmer, Cecilia Williams, Simon L. Goodman
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
In the wake of the reproducibility crisis and numerous discussions on how commercially available antibodies as research tool contribute to it, The Antibody Society developed a series of 10 webinars to address the issues involved. The webinars were de
Externí odkaz:
https://doaj.org/article/c2882a1d3d4c4f5fbfd4271ba95791db
Autor:
Winnie L. Kan, Urmi Dhagat, Kerstin B. Kaufmann, Timothy R. Hercus, Tracy L. Nero, Andy GX. Zeng, John Toubia, Emma F. Barry, Sophie E. Broughton, Guillermo A. Gomez, Brooks A. Benard, Mara Dottore, Karen S. Cheung Tung Shing, Helena Boutzen, Saumya E. Samaraweera, Kaylene J. Simpson, Liqing Jin, Gregory J. Goodall, C. Glenn Begley, Daniel Thomas, Paul G. Ekert, Denis Tvorogov, Richard J. D'Andrea, John E. Dick, Michael W. Parker, Angel F. Lopez
Publikováno v:
Cancer Discovery.
Leukemia stem cells (LSC) possess distinct self-renewal and arrested differentiation properties that are responsible for disease emergence, therapy failure and recurrence in acute myeloid leukemia (AML). Despite AML displaying extensive biological an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc41572709858062712a31dec8e1417
https://doi.org/10.1158/2159-8290.cd-22-1396
https://doi.org/10.1158/2159-8290.cd-22-1396
Autor:
Michael Bettess, Simon Fisher, James S. Rush, Christopher Davis, Ian H. Frazer, Jonathan B. Baell, Michael P. Brown, Mark Sullivan, Michael P. Jennings, Michael A. McGuckin, Eloise Keeffe, Craig Rayner, Anand Gautam, Philip Kearney, C. Glenn Begley, Brett Carter, William N. Charman, Michael W. Parker, Mark R. Ashton, Brett Roberts, Angel F. Lopez, Darren J. Kelly
Publikováno v:
Science translational medicine. 13(612)
Drug repurposing is promoted as a cost- and time-effective mechanism for providing new medicines. Often, however, there is insufficient consideration by academic researchers of the processes required to ensure that a repurposed drug can be used for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fd4678be2e05d0047237accbbe9583
https://pubmed.ncbi.nlm.nih.gov/34550729
https://pubmed.ncbi.nlm.nih.gov/34550729
Autor:
C. Glenn Begley, Steven M. Snapinn
Publikováno v:
Statistics in Biopharmaceutical Research. 13:40-42
In his excellent article, Gibson (2020) argues that the replication crisis in science is not the fault of p-values, but rather largely a consequence of excessive optimism. We agree with the author’...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7340834da697afac3515f25c5bcdc624
https://doi.org/10.1080/19466315.2020.1782259
https://doi.org/10.1080/19466315.2020.1782259
Autor:
Scott D Patterson, John M Rossi, Katherine L Paweletz, V Dan Fitzpatrick, C Glenn Begley, Leigh Busse, Steve Elliott, Ian McCaffery
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122149 (2015)
Several clinical trials in oncology have reported increased mortality or disease progression associated with erythropoiesis-stimulating agents. One hypothesis proposes that erythropoiesis-stimulating agents directly stimulate tumor proliferation and/
Externí odkaz:
https://doaj.org/article/cfa6893608d54c5d9b9b086c3645e23b
Autor:
James E. Trosko, Carr J. Smith, C. Glenn Begley, Thomas A. Perfetti, Sir Colin Berry, Jay I. Goodman, Judy A. King, A. Wallace Hayes, Anthony Dayan
Publikováno v:
Archives of Toxicology.
The International Agency for Research on Cancer (IARC) has recently proposed employing “ten key characteristics of human carcinogens” (TKCs) to determine the potential of agents for harmful effects. The TKCs seem likely to confuse the unsatisfact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b30760626e4c2c117c09af2f84684925
https://doi.org/10.1007/s00204-021-03109-w
https://doi.org/10.1007/s00204-021-03109-w
Autor:
Carr J, Smith, Thomas A, Perfetti, A Wallace, Hayes, Sir Colin, Berry, James E, Trosko, Judy A, King, Jay I, Goodman, C Glenn, Begley, Anthony, Dayan
Publikováno v:
Archives of toxicology. 95(8)
The International Agency for Research on Cancer (IARC) has recently proposed employing "ten key characteristics of human carcinogens" (TKCs) to determine the potential of agents for harmful effects. The TKCs seem likely to confuse the unsatisfactory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb98ed16a3971023172e7b356189db58
https://pubmed.ncbi.nlm.nih.gov/34148101
https://pubmed.ncbi.nlm.nih.gov/34148101
Autor:
Alejandra Solache, Aldrin V. Gomes, Cecilia Williams, James S. Trimmer, Simon L. Goodman, Travis Hardcastle, C. Glenn Begley, Andrew Bradbury, Andrew D. Chalmers, Fridtjof Lund-Johansen, Giovanna Roncador, Andreas Plückthun, Anita Bandrowski, Michael J. Taussig, Jan L.A. Voskuil
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
In the wake of the reproducibility crisis and numerous discussions on how commercially available antibodies as research tool contribute to it, The Antibody Society developed a series of 10 webinars to address the issues involved. The webinars were de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72b8ba9caa690de67057299bf9f6ad9
https://doi.org/10.1080/19420862.2020.1794421
https://doi.org/10.1080/19420862.2020.1794421