Výsledky vyhledávání - "C Gianna Hoffman-Luca"

Akademický článek

Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment.

Autor: C Gianna Hoffman-Luca, Chao-Yie Yang, Jianfeng Lu, Daniel Ziazadeh, Donna McEachern, Laurent Debussche, Shaomeng Wang

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128807 (2015)

SAR405838 is a potent and specific MDM2 inhibitor currently being evaluated in Phase I clinical trials for the treatment of human cancer. Using the SJSA-1 osteosarcoma cell line which harbors an amplified MDM2 gene and wild-type p53, we have investig

Externí odkaz: https://doaj.org/article/e0f16c2bfe2e4121ac305783ca6bfeb1

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Supplemental Figure S5 and Figure S6 from Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo

Autor: Shaomeng Wang, Laurent Debussche, Wei Sun, Yujun Zhao, Donna McEachern, Daniel Ziazadeh, C. Gianna Hoffman-Luca

Supplemental Figure S5 and Figure S6. Figure S5. Testing the role of BAX and BAK for the activity of ABT-263 or SAR in MV4;11 cells. Figure S6. Evaluation of the role of p53 for the activity of SAR and ABT-263 in the MV4;11 cell line.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16a736b14d30e851333b8a3112e5071
https://doi.org/10.1158/1078-0432.22459064

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Supplemental Figure S4 from Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo

Autor: Shaomeng Wang, Laurent Debussche, Wei Sun, Yujun Zhao, Donna McEachern, Daniel Ziazadeh, C. Gianna Hoffman-Luca

Supplemental Figure S4. Further Characterization of MV4;11 sublines obtained from in vitro treatment with ABT-263 or SAR.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40dac23928286374dfb3c8c8c028198
https://doi.org/10.1158/1078-0432.22459067.v1

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Supplemental Table S1, Table S2 and Table S3 from Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo

Autor: Shaomeng Wang, Laurent Debussche, Wei Sun, Yujun Zhao, Donna McEachern, Daniel Ziazadeh, C. Gianna Hoffman-Luca

Supplemental Table S1, Table S2 and Table S3. Table S1. Sequencing of p53 in RS4;11 cell lines. Table S2. Combination index analysis of and SAR405838 and ABT-263 in the RS4;11 and MV4;11 cell lines in cell growth assay. Table S3. Combination index an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1746ce506979150c13a3f057bc877863
https://doi.org/10.1158/1078-0432.22459055

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Data from Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo

Autor: Shaomeng Wang, Laurent Debussche, Wei Sun, Yujun Zhao, Donna McEachern, Daniel Ziazadeh, C. Gianna Hoffman-Luca

Purpose: Two clinical-stage anticancer drugs, the Bcl-2 inhibitor ABT-263, and the MDM2 inhibitor SAR405838 achieve complete tumor regression in animal models of leukemia but also induce acquired resistance. Elucidation of acquired resistance mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4942a9966acc75b55040667e28c93c84
https://doi.org/10.1158/1078-0432.c.6524123

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Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo

Autor: C. Gianna Hoffman-Luca, Yujun Zhao, Donna McEachern, Shaomeng Wang, Laurent Debussche, Wei Sun, Daniel Ziazadeh

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 21(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b426bfd163dbf76747f04c90ce58ee98
https://pubmed.ncbi.nlm.nih.gov/25754349

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Formation of a triply bridged mu-oxo diiron(III) core stabilized by two deprotonated carboxamide groups upon photorelease of NO from a [Fe-NO]6 iron nitrosyl

Autor: Aura A. Eroy-Reveles, C. Gianna Hoffman-Luca, Pradip K. Mascharak

Publikováno v: Dalton transactions (Cambridge, England : 2003). (45)

The iron nitrosyl [(PaPy2Q)Fe(NO)](ClO4)2 (2), derived from the quinoline-based ligand PaPy2QH (N,N-bis(2-pyridylmethyl)amine-N-ethyl-2-quinoline-2-carboxamide, where H is dissociable proton) has been characterized by spectroscopy and X-ray diffracti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d9ca75afd0e7328ec4ee3a2c233101
https://pubmed.ncbi.nlm.nih.gov/18271482

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Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment

Autor: Chao Yie Yang, Jianfeng Lu, C. Gianna Hoffman-Luca, Donna McEachern, Daniel Ziazadeh, Shaomeng Wang, Laurent Debussche

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128807 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb79fafd41a7266c258bd6de93d95434
https://doi.org/10.1371/journal.pone.0128807

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Abstract C250: Concurrent targeting Bcl-2/Bcl-xL and MDM2 as a new therapeutic strategy for acute leukemia

Autor: Daniel Ziazadeh, C. Gianna Hoffman-Luca, Laurent Debussche, Yujun Zhao, Wei Sun, Donna McEachern, Shaomeng Wang

Publikováno v: Molecular Cancer Therapeutics. 12:C250-C250

Acquired resistance of tumor cells to anticancer drugs is a major cause of cancer therapy failure in the clinic. In this study, we have investigated the acquired resistance mechanisms in vitro and in vivo for two novel anticancer drugs currently in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bec8246202952d087426681c1f80613
https://doi.org/10.1158/1535-7163.targ-13-c250

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