Zobrazeno 1 - 10
of 98
pro vyhledávání: '"C G Regårdh"'
Publikováno v:
European Journal of Clinical Pharmacology. 38:421-424
The biliary secretion of [14C]felodipine in 4 healthy human subjects was studied by use of the multiple marker dilution principle with double lumen tubes placed in the stomach and intestine. Insignificant amounts of 14C activity were recovered from g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d96f765a79bfc26b9dfe08601e57553
https://doi.org/10.1007/bf02336677
https://doi.org/10.1007/bf02336677
Publikováno v:
Journal of pharmaceutical sciences. 89(1)
The objective of this study was a systematic characterization and evaluation of cell culture models based on mixtures of Caco-2/HT29-MTX co-cultures for their use in screening for drug absorption and intestinal permeability in comparison to the prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dde5830a268592a1853b59c4b586982b
https://pubmed.ncbi.nlm.nih.gov/10664539
https://pubmed.ncbi.nlm.nih.gov/10664539
Publikováno v:
Journal of pharmaceutical sciences. 88(10)
It has been shown in vivo and in vitro that P-glycoprotein (P-gp) may be able to influence the permeability of its substrates across biological membranes. However, the quantitative contribution of the secretion process mediated by P-gp on the overall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::086b87900086d2f1380fb33e0ca50463
https://pubmed.ncbi.nlm.nih.gov/10514357
https://pubmed.ncbi.nlm.nih.gov/10514357
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(5)
Clevidipine is a new vascular selective calcium channel antagonist of the dihydropyridine type, structurally related to felodipine. Clinical trials have shown that the drug can be used to effectively control the blood pressure in connection with card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::553c179bd4ac584e98b516f000ccdfef
https://pubmed.ncbi.nlm.nih.gov/10220482
https://pubmed.ncbi.nlm.nih.gov/10220482
Autor:
S, Döppenschmitt, P, Langguth, C G, Regårdh, T B, Andersson, C, Hilgendorf, H, Spahn-Langguth
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(1)
Interaction with the exsorptive transporter P-glycoprotein (P-gp) is a possible source of peculiarities in drug pharmacokinetics, including dose-dependent absorption, drug-drug interactions, intestinal secretion, and limited permeability of the blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50bc7594429bd95a6595bd8bb6fe86bf
https://pubmed.ncbi.nlm.nih.gov/9862789
https://pubmed.ncbi.nlm.nih.gov/9862789
Publikováno v:
Pharmaceutical research. 15(7)
To develop a rapid and reliable system for affinity determination of conventional as well as newly synthesized compounds to P-gp.The principles of radioligand-binding assay were adapted to the human intestinal P-gp. Acceptor protein was obtained from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::060f2320b75677a3988a4aed9b5cf229
https://pubmed.ncbi.nlm.nih.gov/9688051
https://pubmed.ncbi.nlm.nih.gov/9688051
Publikováno v:
Biopharmaceuticsdrug disposition. 19(1)
Pharmacokinetics, excretion, and metabolism of inogatran, a low-molecular-weight thrombin inhibitor, were studied in the rat, dog, and cynomolgus monkey. After intravenous administration the half-life was short in all three animal species, due to a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd5402d09a38d8ce497351dd1ca7074e
https://pubmed.ncbi.nlm.nih.gov/9510985
https://pubmed.ncbi.nlm.nih.gov/9510985
Publikováno v:
European Journal of Clinical Pharmacology. 49
In this randomised, cross-over study, in nine healthy males given felodipine ER 10 mg PO 200 ml grapefruit juice was found to increase the plasma levels of felodipine even when the juice was taken 24 hours before the drug. Grapefruit juice drunk simu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1086435bbcafe4ca3c17c90d09f2d74a
https://doi.org/10.1007/bf00192360
https://doi.org/10.1007/bf00192360
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 266(1)
The central nervous and systemic kinetics of ramipril, an angiotensin-converting enzyme inhibitor prodrug, and its active metabolite ramiprilat were studied in conscious beagle dogs after sampling of cerebrospinal fluid (CSF) and blood during chronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a280cedee23b8a86734867c650aae515
https://pubmed.ncbi.nlm.nih.gov/8331554
https://pubmed.ncbi.nlm.nih.gov/8331554
Autor:
H, Lennernäs, C G, Regårdh
Publikováno v:
Pharmaceutical research. 10(6)
Pafenolol is a beta-blocker with unusual oral absorption properties. The blood concentration-time profile exhibits two peaks, and the bioavailability is low and dose dependent because of incomplete and nonlinear intestinal uptake. We addressed the qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc4a10ea4a79ec41fbb8212edba90654
https://pubmed.ncbi.nlm.nih.gov/8100633
https://pubmed.ncbi.nlm.nih.gov/8100633