Výsledky vyhledávání

Overexpression of Fibrinogen-Like Protein 2 Promotes Tolerance in a Fully Mismatched Murine Model of Heart Transplantation

Autor: Lin Zhang, Wei He, Andrzej Chruscinski, Agata Bartczak, Jianyu Zhang, M. Mendicino, David R. Grant, M. J. Phillips, Oyedele Adeyi, Hao Liu, Ramzi Khattar, A. Nguyen, Reginald M. Gorczynski, Hassan Sadozai, A. Z. Amir, C. G. Lobe, Gary A. Levy

Publikováno v: American Journal of Transplantation. 16:1739-1750

Fibrinogen-like protein 2 (FGL2) is an immunomodulatory protein that is expressed by regulatory T cells (Tregs). The objective of this study was to determine if recombinant FGL2 (rFGL2) treatment or constitutive FGL2 overexpression could promote tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe4fea955ea53cc14b1e6383b8164f9
https://doi.org/10.1111/ajt.13696

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A comparison of Notch, Hes and Grg expression during murine embryonic and post-natal development

Autor: T, Allen, C G, Lobe

Publikováno v: Cellular and molecular biology (Noisy-le-Grand, France). 45(5)

Mammalian Hairy/Enhancer-of-split-like (Hes) proteins interact with transcriptional corepressors encoded by the Groucho-related genes (Grg in mice). We have examined the embryonic and postnatal expression of the Hes1 and Hes3 genes as well as all fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb72e5eaf2b882fcf797ee25f4e02131
https://pubmed.ncbi.nlm.nih.gov/10512199

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Conditional genome alteration in mice

Autor: C G, Lobe, A, Nagy

Publikováno v: BioEssays : news and reviews in molecular, cellular and developmental biology. 20(3)

The recent ability to inactivate specific genes in mice has significantly accelerated our understanding of molecular, cellular, and even behavioral aspects of normal and disease processes. However, this ability has also demonstrated the extreme compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd81c2e38a1cdaa7c1b5f9d7b978b911
https://pubmed.ncbi.nlm.nih.gov/9631647

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Grg3, a murine Groucho-related gene, is expressed in the developing nervous system and in mesenchyme-induced epithelial structures

Autor: C, Leon, C G, Lobe

Publikováno v: Developmental dynamics : an official publication of the American Association of Anatomists. 208(1)

We have isolated cDNAs representing multiple members of murine groucho homologues, designated Grg for groucho-related genes. Among them, Grg3 appears to produce two transcripts. One of the Grg3 transcripts contains coding sequence for a complete Grou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac8a342a6414c97a220a25319c70cb16
https://pubmed.ncbi.nlm.nih.gov/8989517

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From Drosophila to Mouse

Autor: C. G. Lobe, P. Gruss

Publikováno v: Development ISBN: 9783642770456

The study of development in mammals is of particular interest, not only because of important relevant applications to medicine and agriculture, but also because there is a natural curiosity to learn about the process of embryology in humans. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::def68ae8c755354e7ae30a488b45a3e4
https://doi.org/10.1007/978-3-642-77043-2_27

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Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes

Autor: C G Lobe, C Havele, R C Bleackley

Publikováno v: Proceedings of the National Academy of Sciences. 83:1448-1452

The intracellular events leading to cytotoxic T-lymphocyte (CTL) activation and the molecular mechanism of target-cell lysis remain largely unknown. Differential hybridization analysis of a library constructed from a cloned CTL line was used to ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794a389354a0f92b34938305facaf732
https://doi.org/10.1073/pnas.83.5.1448

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A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor

Autor: Christoph Mueller, C G Lobe, Irving L. Weissman, Craig Okada, Howard K. Gershenfeld, R C Bleackley

Publikováno v: The Journal of Experimental Medicine

The role of cytotoxic cells in in vivo immune functions such as allograft rejection is unknown. To begin to assess the function of cytolytic cells in vivo we have begun with cytolytic cell-specific functional molecules: we have isolated and character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85a9b8491a573bf28eaad04288fa22e
https://doi.org/10.1084/jem.167.3.1124

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