The Immune Privilege of the Eye: Human Retinal Pigment Epithelial Cells Selectively Modulate T-Cell ActivationIn Vitro

Autor: Niels Ødum, Paola Lovato, Carsten Röpke, C G Kaestel, Mogens Holst Nissen

Publikováno v: Current Eye Research. 30:375-383

To examine the effect of human retinal pigment epithelial (RPE) cells on phytohemagglutinin (PHA) activation of T cells.Resting peripheral blood lymphocytes (PBLs) were stimulated with PHA with or without the presence of gamma-irradiated RPE cells. P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5670cdf57c5768b4da6d939f1b1f72c
https://doi.org/10.1080/02713680590934120

Superantigen Presentation by Human Retinal Pigment Epithelial Cells to T Cells is Dependent on CD2–CD58 and CD18–CD54 Molecule Interactions

Autor: C G Kaestel, Mogens Holst Nissen, Carsten Röpke, A. Jørgensen, Ge M. Lui, Ye Liang, Morten L. A. Cour, Anne Katrine Wiencke, Niels Ødum, Niels Junker

Publikováno v: Experimental Eye Research. 73:723-733

Human retinal pigment epithelial (RPE) cells are capable of presenting bacterial superantigens (SAg) to T cells in vitro by ligation of MHC class II molecules on RPE cells with the T cell receptor. The purpose of this study was to evaluate the involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d43caf4c3635cd4fcdb7ce8e0f49ad
https://doi.org/10.1006/exer.2001.1082

Bcl-2, Bax, and c-Fos expression correlates to RPE cell apoptosis induced by UV-light and daunorubicin

Autor: Mogens Holst Nissen, Ye Liang, Morten la Cour, C G Kaestel, Anne Katrine Wiencke, A. Jørgensen, Ge M. Lui, Carsten Röpke

Publikováno v: Current Eye Research. 20:25-34

Purpose. The aim of this study was to determine the role of Bcl-2, Bcl-X L, Bax, and c-Fos in regulation of apoptosis, induced by ultraviolet-light A (UV-A) and daunorubicin (DNR), in retinal pigment epithelium (RPE) cells grown on bovine extracellul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7ed03c80fd1f480aa2b51bb67dcf34
https://doi.org/10.1076/0271-3683(200001)2011-hft025

Human retinal pigment epithelial cells inhibit proliferation and IL2R expression of activated T cells

Autor: C G Kaestel, Mette Olaf Nielsen, Mogens Holst Nissen, Karsten W. Eriksen, Niels Ødum, A. Jørgensen, Carsten Röpke

Publikováno v: Experimental eye research. 74(5)

The purpose of this study was to characterize the effects of human retinal pigment epithelial (RPE) cells on activated T cells. Activated T cells were cocultured with adult and foetal human RPE cells whereafter apoptosis and proliferation were determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea72690bd27915a46fa2a745432f2508
https://pubmed.ncbi.nlm.nih.gov/12076084

Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells

Autor: Carsten Geisler, M. Nielsen, Keld Kaltoft, Anders Woetmann, Karsten W. Eriksen, Carsten Röpke, Niels Ødum, T Stokkedal, C G Kaestel

Publikováno v: University of Copenhagen
Nielsen, M, Kaestel, C G, Eriksen, K W, Woetmann, A, Stokkedal, T, Kaltoft, K, Geisler, C, Ropke, C & Odum, N 1999, ' Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells ' Leukemia, bind 13, nr. 5, s. 735-738 .

The Jak/Stat signaling pathway transmits signals from many cytokine and growth factor receptors to target genes in the nucleus. Constitutive activation of Stat3 has recently been observed in many tumor cells and dysregulation of the Stat signaling pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baed51dd325e291d1edf51e520eb4cee
https://curis.ku.dk/portal/en/publications/inhibition-of-constitutively-activated-stat3-correlates-with-altered-bcl2bax-expression-and-induction-of-apoptosis-in-mycosis-fungoides-tumor-cells(258e3f20-b0a3-11dd-b538-000ea68e967b).html