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Safety and activity of alectinib plus bevacizumab in patients with advanced ALK-rearranged non-small-cell lung cancer: a phase I/II study

Autor: J J, Lin, A, Muzikansky, E, Kennedy, H, Kuberski, L L, Stober, A C, Wanat, C G, Azzoli, I, Lennes, L V, Sequist, I, Dagogo-Jack, A T, Shaw, J F, Gainor

Publikováno v: ESMO Open

Background Alectinib, a second-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI), is highly effective in advanced ALK-rearranged non-small-cell lung cancer and represents a standard first-line therapy. New strategies are nee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295fe154a393d7792ed6a71b70a93f6f
https://doi.org/10.1016/j.esmoop.2021.100342

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Cooperation of p53 loss of function and v-Ha-ras in transformation of mouse keratinocyte cell lines

Autor: C G, Azzoli, M, Sagar, A, Wu, D, Lowry, H, Hennings, D L, Morgan, W C, Weinberg

Publikováno v: Molecular carcinogenesis. 21(1)

We previously demonstrated that after transduction with the v-Ha-ras oncogene and grafting onto nude mouse hosts, primary epidermal keratinocytes with a null mutation in the p53 gene form tumors with increased growth rates and predisposition to malig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f33d953fd54541e12da5cf0d5af11e5
https://pubmed.ncbi.nlm.nih.gov/9473771

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p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein

Autor: W C, Weinberg, C G, Azzoli, K, Chapman, A J, Levine, S H, Yuspa

Publikováno v: Oncogene. 10(12)

The regulation of p53 protein synthesis and p53-mediated gene transactivation were evaluated in cultured mouse keratinocytes maintained as basal cells or induced to differentiate by Ca2+0.1 mM. p53 protein half-life, p53 protein synthesis and the lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::063124ec30597d8ec4283e19161a4e8e
https://pubmed.ncbi.nlm.nih.gov/7784075

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p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene

Autor: W C, Weinberg, C G, Azzoli, N, Kadiwar, S H, Yuspa

Publikováno v: Cancer research. 54(21)

Epidermal keratinocyte cultures were established from newborn mice expressing a null mutation in the p53 gene to explore the contribution of p53 to epidermal growth regulation and neoplasia. Keratinocytes were initiated by transduction with a replica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::019e3d702c4c97d763c326e6f9327c86
https://pubmed.ncbi.nlm.nih.gov/7923201

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Combined inhibition of mTOR and EGFR with everolimus (RAD001) and gefitinib in patients with non-small cell lung cancer who have smoked cigarettes: A phase II trial

Autor: C. G. Azzoli, N. A. Rizvi, W. Pao, V. A. Miller, Gregory J. Riely, R. T. Heelan, D. T. Milton, E. Moore, L. M. Krug, M. G. Kris

Publikováno v: Journal of Clinical Oncology. 25:7575-7575

7575 Background: Most non-small cell lung cancers (NSCLC) are primarily resistant to the EGFR tyrosine kinase inhibitor gefitinib. One strategy to overcome resistance is to block parallel or downstream effectors that maintain tumor growth and prolife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f299a721136a55a37a23d1831139f60b
https://doi.org/10.1200/jco.2007.25.18_suppl.7575

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