Zobrazeno 1 - 10
of 130
pro vyhledávání: '"C Finnemann"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5299 (2024)
Greg Lemke’s laboratory was one of the pioneers of research into the TAM family of receptor tyrosine kinases (RTKs). Not only was Tyro3 cloned in his laboratory, but his group also extensively studied mice knocked out for individual or various comb
Externí odkaz:
https://doaj.org/article/03ec2d28b0814b34bb11b3ee6dfb288c
Autor:
Fangyuan Gao, Emily Tom, Stephanie A. Lieffrig, Silvia C. Finnemann, Dorota Skowronska-Krawczyk
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionThe vertebrate retinal pigment epithelium (RPE) lies adjacent to the photoreceptors and is responsible for the engulfment and degradation of shed photoreceptor outer segment fragments (POS) through receptor-mediated phagocytosis. Phagocyt
Externí odkaz:
https://doaj.org/article/bfc1cc3bb8ac44d3b57181b2619161f1
Autor:
Devin Rocks, Mamta Shukla, Laila Ouldibbat, Silvia C. Finnemann, Achyuth Kalluchi, M. Jordan Rowley, Marija Kundakovic
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here the authors provide evidence that 3D chromatin structure in the mouse brain differs between males and females and undergoes dynamic remodelling during the female ovarian cycle. They show female-specific 3D genome dynamics affects neuronal gene e
Externí odkaz:
https://doaj.org/article/202b6f36f95a42a1a01547b4b2b59f11
Autor:
Yemsratch T Akalu, Maria E Mercau, Marleen Ansems, Lindsey D Hughes, James Nevin, Emily J Alberto, Xinran N Liu, Li-Zhen He, Diego Alvarado, Tibor Keler, Yong Kong, William M Philbrick, Marcus Bosenberg, Silvia C Finnemann, Antonio Iavarone, Anna Lasorella, Carla V Rothlin, Sourav Ghosh
Publikováno v:
eLife, Vol 11 (2022)
Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a presumed consequence of gene KO, mice display certain phenotypes. Based on insight into the molecular role
Externí odkaz:
https://doaj.org/article/43fad56f4e26479584968f8d6e15f037
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Clearance phagocytosis is a documented function of Müller glia in the retina. However, the molecular mechanisms of Müller glia phagocytosis remain largely undefined. Here, we show that extracellular galectin-3 and protein S promote clearance phagoc
Externí odkaz:
https://doaj.org/article/ba3f7702055948efb2ecc083f074bcc1
Autor:
Jade A. Vargas, Silvia C. Finnemann
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9466 (2022)
In all mammalian species tested to date, rod photoreceptor outer segment renewal is a circadian process synchronized by light with a burst of outer segment fragment (POS) shedding and POS phagocytosis by the adjacent retinal pigment epithelium (RPE)
Externí odkaz:
https://doaj.org/article/39426b2d715846b79edcda6d8d05c387
Publikováno v:
Redox Biology, Vol 42, Iss , Pp 101918- (2021)
Methionine sulfoxide reductase A (MsrA) is a widely expressed antioxidant enzyme that counteracts oxidative protein damage and contributes to protein regulation by reversing oxidation of protein methionine residues. In retinal pigment epithelial (RPE
Externí odkaz:
https://doaj.org/article/0efcf6d862c644fc828b83acea40accc
Autor:
Francesca Mazzoni, Claudia Müller, Jonathan DeAssis, Deborah Lew, W. Matthew Leevy, Silvia C. Finnemann
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Abstract Phosphatidylserine externalization is an early molecular signature for apoptosis. In many retinal degenerative diseases, photoreceptor neurons die by apoptosis. Here, we report utility of the phosphatidylserine-binding conjugate of Bis(zinc(
Externí odkaz:
https://doaj.org/article/b9a3c646aa1d4bb2a8a8cbe6cc25c001
Autor:
Jade A. Vargas, Silvia C. Finnemann
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3661 (2022)
In the vertebrate retina, the light-sensitive photoreceptor rods and cones constantly undergo renewal by generating new portions of the outer segment and shedding their distal, spent tips. The neighboring RPE provides the critical function of engulfi
Externí odkaz:
https://doaj.org/article/3403d2954c994449b1f048ba9d9429bb
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Retinitis Pigmentosa (RP) is a group of inherited retinal diseases characterized by progressive loss of rod followed by cone photoreceptors. An especially early onset form of RP with blindness in teenage years is caused by mutations in mertk, the gen
Externí odkaz:
https://doaj.org/article/3af224a5d28b4781ad42af6015f1e145