Zobrazeno 1 - 10
of 269
pro vyhledávání: '"C Fehling"'
Autor:
Aubrey L. Miller, Samuel C. Fehling, Patrick L. Garcia, Tracy L. Gamblin, Leona N. Council, Robert C.A.M. van Waardenburg, Eddy S. Yang, James E. Bradner, Karina J. Yoon
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 419-430 (2019)
Background: DNA repair deficiency accumulates DNA damage and sensitizes tumor cells to PARP inhibitors (PARPi). Based on our observation that the BET inhibitor JQ1 increases levels of DNA damage, we evaluated the efficacy of JQ1 + the PARPi olaparib
Externí odkaz:
https://doaj.org/article/06329e4890dc457f95f1890ebe29c231
Autor:
Denise L. Smith, Jeannie M. Haller, Maria Korre, Patricia C. Fehling, Konstantina Sampani, Luiz Guilherme Grossi Porto, Costas A. Christophi, Stefanos N. Kales
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 18 (2018)
Background Sudden cardiac death accounts for the greatest proportion of duty‐related deaths among US firefighters. Increased understanding of the pathoanatomic causes of sudden cardiac death and the risk associated with underlying cardiac pathologi
Externí odkaz:
https://doaj.org/article/07d46fa616b84ada9658c31b35e2943b
Autor:
Tara C. Fehling-Fraser, Eliane Ceccon
Publikováno v:
Revista Chapingo: Serie Ciencias Forestales y del Ambiente, Vol 21, Iss 1, Pp 5-16 (2015)
L a deforestación en México ha hecho que la restauración sea una necesidad urgente. Erythrina americana es un árbol multipropósito, útil para la restauración de bosques tropicales estacionalmente secos (BTES), pero es poco estudiado. La macrop
Externí odkaz:
https://doaj.org/article/272da23196924797930438ec79c26e68
Publikováno v:
Cancer Lett
Our previous finding that the BET inhibitor (BETi) JQ1 increases levels of the DNA damage marker γH2AX suggested that JQ1 might enhance the sensitivity of tumor cells to PARP inhibitors (PARPi), which are selectively toxic to cells that harbor relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e817cb0ee1d8f937ad41afd02d611d81
https://doi.org/10.1016/j.canlet.2019.10.011
https://doi.org/10.1016/j.canlet.2019.10.011
Autor:
Aubrey L. Miller, Patrick L. Garcia, Samuel C. Fehling, Tracy L. Gamblin, Rebecca B. Vance, Leona N. Council, Dongquan Chen, Eddy S. Yang, Robert C. A. M. van Waardenburg, Karina J. Yoon
Publikováno v:
Cancers, Vol 13, Iss 3470, p 3470 (2021)
Cancers
Volume 13
Issue 14
Cancers
Volume 13
Issue 14
Gemcitabine is used to treat pancreatic cancer (PC), but is not curative. We sought to determine whether gemcitabine + a BET bromodomain inhibitor was superior to gemcitabine, and identify proteins that may contribute to the efficacy of this combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b956466b29776d684f290d27d614f7
https://www.mdpi.com/2072-6694/13/14/3470
https://www.mdpi.com/2072-6694/13/14/3470
Autor:
Denise L. Smith, Patricia C. Fehling, Adam Frisch, Jeannie M. Haller, Molly Winke, Michael W. Dailey
Publikováno v:
Journal of Obesity, Vol 2012 (2012)
Obesity is associated with increased risk of cardiovascular disease (CVD) mortality. CVD is the leading cause of duty-related death among firefighters, and the prevalence of obesity is a growing concern in the Fire Service. Methods. Traditional CVD r
Externí odkaz:
https://doaj.org/article/089c6d2afee84dc7bd6217170dda9dcd
Autor:
Rebecca C. Arend, Karina J. Yoon, Ronald D. Alvarez, Rebecca B. Vance, Patsy G. Oliver, Samuel C. Fehling, Charles N. Landen, Ashwini A. Katre, Kelly M. Kreitzburg, Robert C.A.M. van Waardenburg, Tracy L. Gamblin
Publikováno v:
Cancer Letters. 436:75-86
Ovarian cancer is the fifth leading cause of cancer-related deaths among women in the United States. Although most patients respond to frontline therapy, virtually all patients relapse with chemoresistant disease. This study addresses the hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69386e1c32b80a8a31951167718d25af
https://doi.org/10.1016/j.canlet.2018.08.015
https://doi.org/10.1016/j.canlet.2018.08.015
Autor:
Chenbei Chang, Gordon P. Meares, Nicolas F. Berbari, Magda Gerigk, Rajani Rajbhandari, Markus Bredel, Amber L. Rowse, G. Kenneth Gray, Chih-Liang Tien, Susan Nozell, Sindhu Nair, Etty N. Benveniste, Kayln C. Mulhern, Samuel C. Fehling
Publikováno v:
Glia. 66:987-998
Previously, we determined microRNA-31 (miR-31) is a non-coding tumor suppressive gene frequently deleted in glioblastoma (GBM); miR-31 suppresses tumor growth, in part, by limiting the activity of NF-κB. Herein, we expand our previous studies by cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11525688eaacf2a9b3c86c872620100f
https://doi.org/10.1002/glia.23296
https://doi.org/10.1002/glia.23296
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Publikováno v:
Experimental Physiology. 101:1541-1551
NEW FINDINGS What is the central question of this study? Although heat stress is known to increase cardiovascular strain, no study, to date, had explored the potential impact of exercise-induced heat stress on vascular function. What is the main find
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b601320936fbe16abfa4983aded051f
https://doi.org/10.1113/ep085828
https://doi.org/10.1113/ep085828