Zobrazeno 1 - 10
of 106
pro vyhledávání: '"C F Starmer"'
Publikováno v:
Journal of Membrane Biology. 207:107-117
Voltage- and/or conformation-dependent association and dissociation of local anesthetic-class drugs from a putative receptor site in domain IV S6 of the sodium channel and slow conformation transitions of the drug-associated channel have been propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd07dcc73c5fc849ac3f0367bb4d8b85
https://doi.org/10.1007/s00232-005-0805-0
https://doi.org/10.1007/s00232-005-0805-0
Publikováno v:
Cardiovascular Research. 42:490-502
Prior studies of the modulation of the Na+ current by sympathetic stimulation have yielded controversial results. Separation of the Na+ and Ca2+ currents poses a problem in myocyte preparations. The gating of cloned Na+ channels is different in oocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25655807c84c909c9cf94f9c1db1da64
https://doi.org/10.1016/s0008-6363(99)00042-5
https://doi.org/10.1016/s0008-6363(99)00042-5
Publikováno v:
Physical Review E. 56:R3757-R3760
The size of a spiral core is predicted on the basis of a boundary-layer analysis of a spiral tip in the nonkinematic limit. Dependencies of a spiral core radius on medium parameters are found analytically and numerically for two models of excitable m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::908619a971d443fd3395f1cae7c065ab
https://doi.org/10.1103/physreve.56.r3757
https://doi.org/10.1103/physreve.56.r3757
Autor:
Joseph M. Starobin, C F Starmer
Publikováno v:
Physical Review E. 55:1193-1196
Spiral waves appear in many excitable chemical and biological media @1#. The spiral wave tip either rotates around a circular unexcited core or meanders, inscribing a noncircular pattern often similar to that of a multipetal flower. From numerical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb1a2897e8fd68fe18cd4ca09dabd0d9
https://doi.org/10.1103/physreve.55.1193
https://doi.org/10.1103/physreve.55.1193
Autor:
V. I. Krinsky, G. Fernández-García, Vicente Pérez-Villar, Alberto P. Muñuzuri, Moncho Gómez-Gesteira, Vicente Pérez-Muñuzuri, C F Starmer
Publikováno v:
Physica D: Nonlinear Phenomena. 76:359-368
Mechanisms for initiating rotating waves in 1D and 2D excitable media were compared and parameters affecting wavefront formation were analyzed. The time delay between two sequentially initiated wavefronts (a conditioning wave followed by a test wave)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dba4ca6a08852758ffd6c09591ce01d0
https://doi.org/10.1016/0167-2789(94)90044-2
https://doi.org/10.1016/0167-2789(94)90044-2
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 266:H2007-H2017
In voltage-clamp studies of atrial myocytes exposed to disopyramide or quinidine, pulse-train stimulation revealed use-dependent block that increased with increased pulse amplitude. Use-dependent block also became negligible at hyperpolarized holding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967b57f8b17da85fa4942ba7d26c6550
https://doi.org/10.1152/ajpheart.1994.266.5.h2007
https://doi.org/10.1152/ajpheart.1994.266.5.h2007
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 264:H1588-H1598
The local anesthetic-class antiarrhythmic drugs produce greater depression of conduction in ischemic compared with normal myocardium. The basis for this relatively selective action is uncertain. A model of the pH-dependent interaction of tertiary ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d24ea491ecd6e127e1759e92ca17080
https://doi.org/10.1152/ajpheart.1993.264.5.h1588
https://doi.org/10.1152/ajpheart.1993.264.5.h1588
Autor:
C F Starmer
Publikováno v:
Journal of Statistical Planning and Inference. 33:99-106
Many biological respomses are dependent on the frequency of excitation. Frequency-dependent processes are a class of ligand binding processes where the degree of binding site saturation may be dependent on the cumulative duration of ligand release or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e538c06094ac1cbe1ad4f00a7cc46e53
https://doi.org/10.1016/0378-3758(92)90095-a
https://doi.org/10.1016/0378-3758(92)90095-a
Publikováno v:
Journal of Clinical Investigation. 90:368-381
A number of basic and clinical studies suggest that elevation of external sodium concentrations, [Na]o, may reverse the cardiotoxic effect of local anesthetic-class drugs. The mechanisms of reversal are uncertain. The blocking action of lidocaine and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379281dc74c3e3e5a00074f7a4c853af
https://doi.org/10.1172/jci115871
https://doi.org/10.1172/jci115871
Publikováno v:
Circulation Research. 70:1254-1273
The recovery of the sodium channel from blockade by local anesthetic antiarrhythmic drugs is voltage dependent. Recovery from lidocaine-induced blockade is accelerated by hyperpolarization, whereas that from glycylxylidide (GX) blockade has been repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5eeef83ecea10a1f6b2f13789d4e4c
https://doi.org/10.1161/01.res.70.6.1254
https://doi.org/10.1161/01.res.70.6.1254