Zobrazeno 1 - 8
of 8
pro vyhledávání: '"C F Sauermelch"'
Publikováno v:
Stroke. 25:2450-2455
(+/-)-SB 209670, a potent nonpeptide endothelin (ET) receptor antagonist, was used to investigate the potential role of ET in cerebral vasospasm associated with subarachnoid hemorrhage. The effects of (+/-)-SB 209670 were evaluated in isolated segmen
Autor:
Giora Z. Feuerstein, C F Sauermelch, Eliot H. Ohlstein, Susanta K. Sarkar, Robert N. Willette, R Rycyna, A J Nichols
Publikováno v:
Stroke. 23:703-711
Platelet-fibrin thrombi in the lumen of atherostenotic carotid arteries may underlie transient ischemic attacks and cerebral infarction. For this reason, we investigated the antiplatelet and antithrombotic effects of a novel and potent platelet fibri
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 259:H1835-H1841
Hemodynamic responses to endothelin (ET-1) were studied in hindquarters of anesthetized rats and also in isolated buffer-perfused hindquarters of pithed rats. ET-1 (10-100 pmol ia) produced brief dose-related increases in hindquarter blood flow. Acet
Publikováno v:
Stroke. 21:451-458
We used laser-Doppler flowmetry to study the effects of endothelin-1 on local cortical microvascular perfusion and resistance in 29 pentobarbital-anesthetized rats. Intravenous administration of 10-300 pmol endothelin-1 reduced arterial blood pressur
Autor:
N, Aiyar, R A, Daines, J, Disa, P A, Chambers, C F, Sauermelch, M, Quiniou, N, Khandoudi, B, Gout, S A, Douglas, R N, Willette
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(3)
Calcitonin gene-related peptide (CGRP), a potent vasodilatory and cardiotonic peptide, has a potential role for CGRP in diverse physiologic and pathophysiologic situations such as congestive heart failure, diabetes, migraine, and neurogenic inflammat
Autor:
R N, Willette, E H, Ohlstein, M P, Mitchell, C F, Sauermelch, G R, Beck, M A, Luttmann, D W, Hay
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(2)
It has been proposed that endothelin-1 (ET-1), a potent endogenous vasoactive peptide, may play an important role in the regulation of pulmonary blood flow. The purpose of the present study was to characterize the effects of ET-1 and a nonpeptide mix
Autor:
C. F. Sauermelch, R. N. Willette
Publikováno v:
The American journal of physiology. 259(6 Pt 2)
Laser-Doppler flowmetry was used to assess the intraparenchymal effects of endothelin 1 (ET-1) on cortical microvascular perfusion (CP). The initial part of this study examined effects of the intraparenchymal microinjection technique on local cortica
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 252(2)
In the pithed rat, postjunctional alpha-1 and alpha-2 adrenoceptors mediate increases in proximal urethral perfusion pressure (UPP). The present study examined the role of alpha-1 and alpha-2 adrenoceptors in sympathetic control of the isolated in si