Zobrazeno 1 - 10
of 11
pro vyhledávání: '"C F, Toombs"'
Autor:
W. P. Sheridan, C. F. Toombs
Publikováno v:
Hämostaseologie. 16:107-113
SummarySince the announcement of the discovery of thrombopoietin in 1994, a tremendous amount of research has determined that recombinant c-mpl ligand (ML) is capable of producing the biological effects of a Meg-CSF and thrombopoietin. Thrombopoietin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ba381f262ab2bc70eea214c40166069
https://doi.org/10.1055/s-0038-1656646
https://doi.org/10.1055/s-0038-1656646
Publikováno v:
Circulation. 88:2351-2358
BACKGROUND Infarct size reduction by ischemic preconditioning is believed to be mediated by adenosine; however, whether adenosine is the factor responsible for the initiation of this protection remains unknown. It is possible that during precondition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c6e0caa99f57a4616d3582b3c754a5
https://doi.org/10.1161/01.cir.88.5.2351
https://doi.org/10.1161/01.cir.88.5.2351
Autor:
William E. Johnston, S. Mcgee, M. S. Ashar, Jakob Vinten-Johansen, Zhi Qing Zhao, C. F. Toombs, Katsuhiko Nakanishi
Publikováno v:
Circulation. 88:709-719
BACKGROUND We hypothesized that: (1) endogenous adenosine released during ischemia/reperfusion reduces infarct size and preserves postischemic myocardial blood flow by receptor-mediated mechanisms and (2) this cardioprotection is exerted predominantl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621fe704adbd7b5e4e4d52291898d6ca
https://doi.org/10.1161/01.cir.88.2.709
https://doi.org/10.1161/01.cir.88.2.709
Publikováno v:
Circulation. 86:986-994
BACKGROUND We hypothesized that 1) endogenous adenosine released during ischemia conferred an inherent cardioprotection, and 2) a pretreatment dose of adenosine before ischemia would provide additional protection independent of hemodynamic effects. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33beda8d923ed4a719207872e3c6b332
https://doi.org/10.1161/01.cir.86.3.986
https://doi.org/10.1161/01.cir.86.3.986
Publikováno v:
Current drug targets. Cardiovascularhaematological disorders. 4(4)
Snake venoms contain a number of serine and metalloproteinases, included among these are the fibrinolytic metalloproteinases. When the fibrinolytic enzymes were first isolated from viper venoms it was postulated that there may be a clinical applicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a5f1865f2b4fe4c8a7a2d0552e5e0f5
https://pubmed.ncbi.nlm.nih.gov/15578961
https://pubmed.ncbi.nlm.nih.gov/15578961
Publikováno v:
Nature. 389(6647)
Platelets are small disc-shaped cell fragments which undergo a rapid transformation when they encounter vascular damage. They become more spherical and extrude pseudopodia, their fibrinogen receptors are activated, causing them to aggregate, they rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9bc43bd05adecf918056b9c500b34e6
https://pubmed.ncbi.nlm.nih.gov/9296496
https://pubmed.ncbi.nlm.nih.gov/9296496
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(2)
It has been established that the fibrin content of a developing thrombus can be dramatically reduced with the use of the GA6 monoclonal antibody, which is directed against P-selectin (CD62p). This effect is probably related to diminished tissue facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::778385633e2ae252036ada15d065a961
https://pubmed.ncbi.nlm.nih.gov/7473186
https://pubmed.ncbi.nlm.nih.gov/7473186
Publikováno v:
Cardiovascular research. 27(4)
Objective: The aim was to test the hypothesis that the cardioprotective effects against ischaemic-reperfusion injury of pretreatment with adenosine are mediated in part by activation of ATP sensitive potassium channels (K+ATP channels). Methods: 42 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e52f397026e0d77eac8dffd64b4d6bf
https://pubmed.ncbi.nlm.nih.gov/8324796
https://pubmed.ncbi.nlm.nih.gov/8324796
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 263(3)
Cromakalim has been shown to have anti-ischemic properties, but it also produces profound hypotension upon systemic administration. We hypothesized that U-89,232, a cromakalim analog, would reduce infarct size in an ischemia-reperfusion injury model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be3fe9b7239b7e9d9354cf1edf8e967f
https://pubmed.ncbi.nlm.nih.gov/1469632
https://pubmed.ncbi.nlm.nih.gov/1469632
Autor:
C. F. Toombs, Jakob Vinten-Johansen, J. S. Julian, William E. Johnston, A. R. Cordell, Hideo Yokoyama
Publikováno v:
The American journal of physiology. 260(6 Pt 2)
The slope and diameter axis intercept (D0) of the linear indexes end-systolic pressure-diameter relation (ESPDR), maximum of the first derivative of left ventricular pressure (dP/dtmax)-end-diastolic diameter relation (dP/dtmax-Ded), and dimensional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d14e918e5cb571eddd28058999ab07
https://pubmed.ncbi.nlm.nih.gov/2058717
https://pubmed.ncbi.nlm.nih.gov/2058717