Zobrazeno 1 - 10
of 79
pro vyhledávání: '"C F, Bennett"'
Autor:
Sonam Bhatia, Habeeb Alsudani, C. F. Bennett, Lily D. Brine, Kung-Chi Chang, Allen T. Yu, Karen Kostroff, Frank Rigo, Edi Brogi, Suzanne Russo, Sarah D. Diermeier, Tawfiqul Bhuiya, David L. Spector
SUMMARYMisregulation of long non-coding RNA genes has been linked to a wide variety of cancer types. Here we report onMammaryTumorAssociatedRNA 25 (MaTAR25), a nuclear enriched and chromatin associated lncRNA that plays a role in mammary tumor cell p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a95c0bc1dff7e1bb3857bd0233b587
https://doi.org/10.1101/2020.02.03.931881
https://doi.org/10.1101/2020.02.03.931881
Autor:
Yimin Hua, Y. J. Kim, Frank Rigo, Rahul Sinha, Adrian R. Krainer, T. Nomakuchi, C. F. Bennett, Kentaro Sahashi
Publikováno v:
Nucleic Acids Research
Familial dysautonomia (FD) is a rare inherited neurodegenerative disorder caused by a point mutation in the IKBKAP gene that results in defective splicing of its pre-mRNA. The mutation weakens the 5′ splice site of exon 20, causing this exon to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8b03aeaf90121d1346eb8b3ef9ae44
https://doi.org/10.1093/nar/gky249
https://doi.org/10.1093/nar/gky249
Autor:
J. Sun, C. F. Bennett, Bo Wan, Adrian R. Krainer, Yimin Hua, L. Sheng, P. Feng, Martin Akerman, Frank Rigo
Publikováno v:
Human Molecular Genetics. 27:486-498
Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality, characterized by progressive degeneration of spinal-cord motor neurons, leading to atrophy of skeletal muscles. However, accumulating evidence indicates that it is a mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e305d242be7af8463411f9cb44eb64
https://doi.org/10.1093/hmg/ddx418
https://doi.org/10.1093/hmg/ddx418
Publikováno v:
Nucleic Acid Therapeutics. 21:A1-A64
The use of Antisense Oligonucleotides (ASOs) for re-directing splicing has shown promising results as a therapeutic approach for several diseases. A showcase for this technology comes from work done on the Survival of Motor Neuron 2 (SMN2) gene. SMN2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc907eb1004bbad2e4c44b5bf4a134b9
https://doi.org/10.1089/nat.2011.1502
https://doi.org/10.1089/nat.2011.1502
Autor:
Stephen M. Ansell, Linda Wellik, D F Jelinek, C. F. Bennett, Bonnie K. Arendt, Ellen D. Remstein, Adele K. Fielding, Deanna M. Grote, Anne J. Novak
Publikováno v:
Leukemia. 18:616-623
Survivin is a member of the inhibitor of apoptosis protein (IAP) family and functions both as an apoptosis inhibitor and a regulator of cell division. Survivin overexpression is common in many human tumors and correlates with survival in large cell n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569f950820b22b16f18dcb5511c47edd
https://doi.org/10.1038/sj.leu.2403281
https://doi.org/10.1038/sj.leu.2403281
Autor:
Adrian J. Shepherd, Christine A. Orengo, C. F. Bennett, Ian Sillitoe, Andrew Harrison, Nigel Martin, Frances M. G. Pearl, James E. Bray, Janet M. Thornton
Publikováno v:
Nucleic Acids Research. 31:452-455
The CATH database of protein domain structures (http://www.biochem.ucl.ac.uk/bsm/cath_new) currently contains 34 287 domain structures classified into 1383 superfamilies and 3285 sequence families. Each structural family is expanded with domain seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad868e789e7b5cb4ff4139f49605a6d
https://doi.org/10.1093/nar/gkg062
https://doi.org/10.1093/nar/gkg062
Autor:
Brett P. Monia, Stanislaw M. Stepkowski, Wenhao Chen, Edward Wancewicz, L Tian, C. F. Bennett, Johnston Jf, Mou-Er Wang, Xiumei Qu
Publikováno v:
Transplantation. 70:656-661
Background. C-raf is a well-characterized serine/ threonine (Ser/Thr) protein kinase that is involved in the transduction of multiple signals of T cells. We demonstrate that the inhibition of C-raf mRNA expression prolongs heart allograft survival. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6e906ecbcc46bf73699b8380fadb77f
https://doi.org/10.1097/00007890-200008270-00020
https://doi.org/10.1097/00007890-200008270-00020
Autor:
James H. Clark, W. Chen, S M Stepkowski, Kahan Bd, C. F. Bennett, K. Stecker, D. Dragun, Mou-Er Wang, Ling Tian
Publikováno v:
Transplantation. 68:880-887
Background. We have previously shown that phosphorothioate intercellular adhesion molecule (ICAM)-1 antisense oligodeoxynucleotide (oligo) IP-9125 blocks the expression of rat ICAM-1 mRNA in rat L2 cells. A single ex situ perfusion of grafts with unf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::964927a8a2055b6411fbffd1f7b62493
https://doi.org/10.1097/00007890-199909270-00022
https://doi.org/10.1097/00007890-199909270-00022
Autor:
K. Stecker, Mark J. Graham, Ling Tian, M-E Wang, Xiumei Qu, B. D. Kahan, Stanislaw M. Stepkowski, Wenhao Chen, C. F. Bennett, T. P. Condon, S. Cheng-Flournoy
Publikováno v:
Transplantation. 66:699-707
BACKGROUND: We designed an antisense phosphorothioate oligodeoxynucleotide (oligo) to specifically inhibit the expression of rat intercellular adhesion molecule-1 (ICAM-1) mRNA (IP-9125). METHODS: IP-9125 oligo was delivered intravenously by osmotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa7c609f773a1c669b9c8910cd24630d
https://doi.org/10.1097/00007890-199809270-00003
https://doi.org/10.1097/00007890-199809270-00003
Autor:
Philip L. Felgner, Carl J. Wheeler, Jiin Felgner, Y. J. Tsai, D Mirejovsky, R M Crooke, C F Bennett, C.N. Sridhar
Publikováno v:
Journal of Drug Targeting. 5:149-162
A series of 2,3-dialkyloxypropyl quaternary ammonium lipids containing hydroxyalkyl chains on the quaternary amine were synthesized, formulated with dioleoylphosphatidylethanolamine (DOPE) and assayed for their ability to enhance the activity of an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dce4725605bdb057705dffb3f8220b
https://doi.org/10.3109/10611869808995870
https://doi.org/10.3109/10611869808995870