Zobrazeno 1 - 10
of 68
pro vyhledávání: '"C Erec Stebbins"'
Autor:
Sara Đaković, Johan P Zeelen, Anastasia Gkeka, Monica Chandra, Monique van Straaten, Konstantina Foti, Janet Zhong, Evi P Vlachou, Francisco Aresta-Branco, Joseph P Verdi, F Nina Papavasiliou, C Erec Stebbins
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011621 (2023)
Long-term immune evasion by the African trypanosome is achieved through repetitive cycles of surface protein replacement with antigenically distinct versions of the dense Variant Surface Glycoprotein (VSG) coat. Thousands of VSG genes and pseudo-gene
Externí odkaz:
https://doaj.org/article/2a7c6745a9b94c0cacb4fc4bd7e1493b
Autor:
Monica Chandra, Sara Đaković, Konstantina Foti, Johan P Zeelen, Monique van Straaten, Francisco Aresta-Branco, Eliane Tihon, Nicole Lübbehusen, Thomas Ruppert, Lucy Glover, F Nina Papavasiliou, C Erec Stebbins
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 2, p e0011093 (2023)
During infection of mammalian hosts, African trypanosomes thwart immunity using antigenic variation of the dense Variant Surface Glycoprotein (VSG) coat, accessing a large repertoire of several thousand genes and pseudogenes, and switching to antigen
Externí odkaz:
https://doaj.org/article/751ce205165247368209f63d3c1aca63
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005784 (2016)
Externí odkaz:
https://doaj.org/article/4c7c8a6a67614660bab3cd1bc5157214
Autor:
Raymond Schuch, Adam J Pelzek, Assaf Raz, Chad W Euler, Patricia A Ryan, Benjamin Y Winer, Andrew Farnsworth, Shyam S Bhaskaran, C Erec Stebbins, Yong Xu, Adrienne Clifford, David J Bearss, Hariprasad Vankayalapati, Allan R Goldberg, Vincent A Fischetti
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60754 (2013)
We identified an essential cell wall biosynthetic enzyme in Bacillus anthracis and an inhibitor thereof to which the organism did not spontaneously evolve measurable resistance. This work is based on the exquisite binding specificity of bacteriophage
Externí odkaz:
https://doaj.org/article/015c5a7ce12a44dcbf5cce9c5e2c60a7
Autor:
Grégory Jubelin, Frédéric Taieb, David M Duda, Yun Hsu, Ascel Samba-Louaka, Rika Nobe, Marie Penary, Claude Watrin, Jean-Philippe Nougayrède, Brenda A Schulman, C Erec Stebbins, Eric Oswald
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001128 (2010)
The cycle inhibiting factors (Cif), produced by pathogenic bacteria isolated from vertebrates and invertebrates, belong to a family of molecules called cyclomodulins that interfere with the eukaryotic cell cycle. Cif blocks the cell cycle at both the
Externí odkaz:
https://doaj.org/article/ffc0c089152b4d21b4a09b0efdf3bbd2
Autor:
Dragana Nesic, C Erec Stebbins
Publikováno v:
PLoS Pathogens, Vol 1, Iss 3, p e28 (2005)
Many bacterial pathogens that cause different illnesses employ the cytolethal distending toxin (CDT) to induce host cell DNA damage, leading to cell cycle arrest or apoptosis. CDT is a tripartite holotoxin that consists of a DNase I family nuclease (
Externí odkaz:
https://doaj.org/article/6c956a5b327c417f8f8fa746e172c50e
Autor:
Monica Chandra, Sara Đaković, Konstantina Foti, Johan Zeelen, Monique van Straaten, Francisco Aresta-Branco, Eliane Tihon, Nicole Lübbehusen, Thomas Ruppert, Lucy Glover, F. Nina Papavasiliou, C. Erec Stebbins
During infection of mammalian hosts, African trypanosomes thwart immunity using antigenic variation of the dense Variant Surface Glycoprotein (VSG) coat, accessing a large repertoire of thousands of genes and pseudogenes and switching to antigenicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::380423546b1fcd99f0b82e9e8fcd1dbc
https://doi.org/10.1101/2022.09.28.508705
https://doi.org/10.1101/2022.09.28.508705
Autor:
Anastasia Gkeka, Francisco Aresta-Branco, Gianna Triller, Evi P. Vlachou, Monique van Straaten, Mirjana Lilic, Paul Dominic B. Olinares, Kathryn Perez, Brian T. Chait, Renata Blatnik, Thomas Ruppert, Joseph P. Verdi, C. Erec Stebbins, F. Nina Papavasiliou
Publikováno v:
Cell Reports. 42:112262
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce6dcef61b9a9d07d4db688d6997cbd9
https://doi.org/10.1016/j.celrep.2023.112262
https://doi.org/10.1016/j.celrep.2023.112262
Autor:
Natalie Wiedemar, F. Nina Papavasiliou, Johan Zeelen, Hamidreza Hashemi, Joseph Verdi, Silvan Hälg, C. Erec Stebbins, Kathryn Perez, Pascal Mäser, Alexander Hempelmann, Philip D. Jeffrey, Monique van Straaten
Publikováno v:
Nature microbiology
Suramin has been a primary early-stage treatment for African trypanosomiasis for nearly 100 yr. Recent studies revealed that trypanosome strains that express the variant surface glycoprotein (VSG) VSGsur possess heightened resistance to suramin. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de7bcea833b26e631f61eb165643ccd
https://doi.org/10.1038/s41564-020-00844-1
https://doi.org/10.1038/s41564-020-00844-1
Autor:
Gianna Triller, Evi P. Vlachou, Hamidreza Hashemi, Monique van Straaten, Johan Zeelen, Yosip Kelemen, Carly Baehr, Cheryl L. Marker, Sandra Ruf, Anna Svirina, Sebastian Kruse, Andreas Baumann, Aubry K. Miller, Marc Bartel, Marco Pravetoni, C. Erec Stebbins, F. Nina Papavasiliou, Joseph P. Verdi
Publikováno v:
SSRN Electronic Journal.
SummaryPoorly antigenic small molecules pose challenges for the production of clinically efficacious antibodies. To address this, we have developed an immunization platform derived from the antigenic surface coat of the African trypanosome. Through s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7a015ca62731ec29721ba9af770b82
https://doi.org/10.2139/ssrn.4131714
https://doi.org/10.2139/ssrn.4131714