Zobrazeno 1 - 10
of 171
pro vyhledávání: '"C Erec Stebbins"'
Autor:
Sara Đaković, Johan P Zeelen, Anastasia Gkeka, Monica Chandra, Monique van Straaten, Konstantina Foti, Janet Zhong, Evi P Vlachou, Francisco Aresta-Branco, Joseph P Verdi, F Nina Papavasiliou, C Erec Stebbins
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011621 (2023)
Long-term immune evasion by the African trypanosome is achieved through repetitive cycles of surface protein replacement with antigenically distinct versions of the dense Variant Surface Glycoprotein (VSG) coat. Thousands of VSG genes and pseudo-gene
Externí odkaz:
https://doaj.org/article/2a7c6745a9b94c0cacb4fc4bd7e1493b
Autor:
Anastasia Gkeka, Francisco Aresta-Branco, Gianna Triller, Evi P. Vlachou, Monique van Straaten, Mirjana Lilic, Paul Dominic B. Olinares, Kathryn Perez, Brian T. Chait, Renata Blatnik, Thomas Ruppert, Joseph P. Verdi, C. Erec Stebbins, F. Nina Papavasiliou
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112262- (2023)
Summary: The African trypanosome survives the immune response of its mammalian host by antigenic variation of its major surface antigen (the variant surface glycoprotein or VSG). Here we describe the antibody repertoires elicited by different VSGs. W
Externí odkaz:
https://doaj.org/article/eb43510b214a4df1a0e7c607d76c984e
Autor:
Monica Chandra, Sara Đaković, Konstantina Foti, Johan P Zeelen, Monique van Straaten, Francisco Aresta-Branco, Eliane Tihon, Nicole Lübbehusen, Thomas Ruppert, Lucy Glover, F Nina Papavasiliou, C Erec Stebbins
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 2, p e0011093 (2023)
During infection of mammalian hosts, African trypanosomes thwart immunity using antigenic variation of the dense Variant Surface Glycoprotein (VSG) coat, accessing a large repertoire of several thousand genes and pseudogenes, and switching to antigen
Externí odkaz:
https://doaj.org/article/751ce205165247368209f63d3c1aca63
Autor:
Gianna Triller, Evi P. Vlachou, Hamidreza Hashemi, Monique van Straaten, Johan P. Zeelen, Yosip Kelemen, Carly Baehr, Cheryl L. Marker, Sandra Ruf, Anna Svirina, Monica Chandra, Katharina Urban, Anastasia Gkeka, Sebastian Kruse, Andreas Baumann, Aubry K. Miller, Marc Bartel, Marco Pravetoni, C. Erec Stebbins, F. Nina Papavasiliou, Joseph P. Verdi
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112049- (2023)
Summary: Poorly immunogenic small molecules pose challenges for the production of clinically efficacious vaccines and antibodies. To address this, we generate an immunization platform derived from the immunogenic surface coat of the African trypanoso
Externí odkaz:
https://doaj.org/article/c7ecefeb83cd43648db62b9d9e7b1931
Autor:
Alexander Hempelmann, Laura Hartleb, Monique van Straaten, Hamidreza Hashemi, Johan P. Zeelen, Kevin Bongers, F. Nina Papavasiliou, Markus Engstler, C. Erec Stebbins, Nicola G. Jones
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109923- (2021)
Summary: The dense variant surface glycoprotein (VSG) coat of African trypanosomes represents the primary host-pathogen interface. Antigenic variation prevents clearing of the pathogen by employing a large repertoire of antigenically distinct VSG gen
Externí odkaz:
https://doaj.org/article/c3acb4d7657a4e0b8cad190d14971cdf
Autor:
Monica Chandra, Sara Đaković, Konstantina Foti, Johan Zeelen, Monique van Straaten, Francisco Aresta-Branco, Eliane Tihon, Nicole Lübbehusen, Thomas Ruppert, Lucy Glover, F. Nina Papavasiliou, C. Erec Stebbins
During infection of mammalian hosts, African trypanosomes thwart immunity using antigenic variation of the dense Variant Surface Glycoprotein (VSG) coat, accessing a large repertoire of thousands of genes and pseudogenes and switching to antigenicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::380423546b1fcd99f0b82e9e8fcd1dbc
https://doi.org/10.1101/2022.09.28.508705
https://doi.org/10.1101/2022.09.28.508705
Autor:
Natalie Wiedemar, F. Nina Papavasiliou, Johan Zeelen, Hamidreza Hashemi, Joseph Verdi, Silvan Hälg, C. Erec Stebbins, Kathryn Perez, Pascal Mäser, Alexander Hempelmann, Philip D. Jeffrey, Monique van Straaten
Publikováno v:
Nature microbiology
Suramin has been a primary early-stage treatment for African trypanosomiasis for nearly 100 yr. Recent studies revealed that trypanosome strains that express the variant surface glycoprotein (VSG) VSGsur possess heightened resistance to suramin. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de7bcea833b26e631f61eb165643ccd
https://doi.org/10.1038/s41564-020-00844-1
https://doi.org/10.1038/s41564-020-00844-1
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005784 (2016)
Externí odkaz:
https://doaj.org/article/4c7c8a6a67614660bab3cd1bc5157214
Autor:
Gianna Triller, Evi P. Vlachou, Hamidreza Hashemi, Monique van Straaten, Johan Zeelen, Yosip Kelemen, Carly Baehr, Cheryl L. Marker, Sandra Ruf, Anna Svirina, Sebastian Kruse, Andreas Baumann, Aubry K. Miller, Marc Bartel, Marco Pravetoni, C. Erec Stebbins, F. Nina Papavasiliou, Joseph P. Verdi
Publikováno v:
SSRN Electronic Journal.
SummaryPoorly antigenic small molecules pose challenges for the production of clinically efficacious antibodies. To address this, we have developed an immunization platform derived from the antigenic surface coat of the African trypanosome. Through s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7a015ca62731ec29721ba9af770b82
https://doi.org/10.2139/ssrn.4131714
https://doi.org/10.2139/ssrn.4131714
Autor:
Monique van Straaten, Karine Lapouge, Monica Chandra, Brandon Waxman, Johan Zeelen, C. Erec Stebbins, Khan Umaer, James D. Bangs, Francisco Aresta-Branco
Publikováno v:
Traffic (Copenhagen, Denmark)REFERENCES. 22(8)
African trypanosomes cause disease in humans and livestock, avoiding host immunity by changing the expression of variant surface glycoproteins (VSGs); the major glycosylphosphatidylinositol (GPI) anchored antigens coating the surface of the bloodstre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bba81f68818a90b0ffc45877a76c8fa
https://pubmed.ncbi.nlm.nih.gov/34101314
https://pubmed.ncbi.nlm.nih.gov/34101314