Zobrazeno 1 - 10
of 286
pro vyhledávání: '"C Ellen, van der Schoot"'
Autor:
Romy T. Meier, Leendert Porcelijn, Suzanne Hofstede-van Egmond, Camila Caram-Deelder, Jonathan M. Coutinho, Yvonne M. C. Henskens, Marieke J. H. A. Kruip, An K. Stroobants, Jaap J. Zwaginga, C. Ellen van der Schoot, Masja de Haas, Rick Kapur
Publikováno v:
Antibodies, Vol 13, Iss 2, p 35 (2024)
Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare but severe complication following COVID-19 vaccination, marked by thrombocytopenia and thrombosis. Analogous to heparin-induced thrombocytopenia (HIT), VITT shares similarities in anti-plat
Externí odkaz:
https://doaj.org/article/eae254c8916047379802a27df9b623a3
Autor:
Zoltán Szittner, Arthur E. H. Bentlage, A. Robin Temming, David E. Schmidt, Remco Visser, Suzanne Lissenberg-Thunnissen, Juk Yee Mok, Wim J. E. van Esch, Myrthe E. Sonneveld, Erik L. de Graaf, Manfred Wuhrer, Leendert Porcelijn, Masja de Haas, C. Ellen van der Schoot, Gestur Vidarsson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate. However, the disease manifests itself in only a fraction of pregnancies, mo
Externí odkaz:
https://doaj.org/article/91e5bf2c71b7454b8cb27f5857ceb701
Autor:
Julie Van Coillie, Tamas Pongracz, Tonći Šuštić, Wenjun Wang, Jan Nouta, Mathieu Le Gars, Sofie Keijzer, Federica Linty, Olvi Cristianawati, Jim B.D. Keijser, Remco Visser, Lonneke A. van Vught, Marleen A. Slim, Niels van Mourik, Merel J. Smit, Adam Sander, David E. Schmidt, Maurice Steenhuis, Theo Rispens, Morten A. Nielsen, Benjamin G. Mordmüller, Alexander P.J. Vlaar, C. Ellen van der Schoot, Ramon Roozendaal, Manfred Wuhrer, Gestur Vidarsson, Brent Appelman, Diederik van de Beek, Marije K. Bomers, Justin de Brabander, Matthijs C. Brouwer, David T.P. Buis, Nora Chekrouni, Marit J. van Gils, Menno D. de Jong, Ayesha H.A. Lavell, Sabine E. Olie, Edgar J.G. Peters, Tom D.Y. Reijnders, Michiel Schinkel, Alex R. Schuurman, Jonne J. Sikkens, Yvo M. Smulders, Joost W. Wiersinga, Antinori Spinello, Cinzia Bassoli, Giovanna Bestetti, Mario Corbellino, Alice Covizzi, Angelica Lupo, Laura Milazzo, Marco Schiuma, Alessandro Torre, Willem A. de Jongh, Ali Salanti, Thor G. Theander, Matthew B.B. McCall, Meral Esen
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107619- (2023)
Summary: IgG antibodies are important mediators of vaccine-induced immunity through complement- and Fc receptor-dependent effector functions. Both are influenced by the composition of the conserved N-linked glycan located in the IgG Fc domain. Here,
Externí odkaz:
https://doaj.org/article/1f6bd129608a46e19f6f87262c09f1b9
Autor:
Eric Toussirot, Daniel Bradshaw, C Ellen van der Schoot, Lise J Estcourt, David J Roberts, Heli Harvala, Pierre Tiberghien, Bart J A Rijnders, Eva Schrezenmeier, Charline Vauchy, Maxime Desmarets, Simone Hoffmann, Antoine Durrbach, Sixten Körper, Gaëlle Brunotte, Thomas Appl, Erhard Seifried, Hubert Schrezenmeier
Publikováno v:
BMJ Open, Vol 13, Iss 4 (2023)
Introduction COVID-19 convalescent plasma (CCP) is a possible treatment option for COVID-19. A comprehensive number of clinical trials on CCP efficacy have already been conducted. However, many aspects of CCP treatment still require investigations: i
Externí odkaz:
https://doaj.org/article/47e9ada6780e45709912246d719e6266
Autor:
Lieke M. J. van Zogchel, Nathalie S. M. Lak, Nina U. Gelineau, Irina Sergeeva, Ellen Stelloo, Joost Swennenhuis, Harma Feitsma, Max van Min, Erik Splinter, Margit Bleijs, Marian Groot Koerkamp, Willemijn Breunis, Michael Torsten Meister, Waleed Hassan Kholossy, Frank C. P. Holstege, Jan J. Molenaar, Wendy W. J. de Leng, Janine Stutterheim, C. Ellen van der Schoot, Godelieve A. M. Tytgat
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundLiquid biopsies combine minimally invasive sample collection with sensitive detection of residual disease. Pediatric malignancies harbor tumor-driving copy number alterations or fusion genes, rather than recurrent point mutations. These reg
Externí odkaz:
https://doaj.org/article/7b442cccd01346f9baef8bf01b4fb357
Autor:
Julie Van Coillie, Tamas Pongracz, Johann Rahmöller, Hung-Jen Chen, Chiara Elisabeth Geyer, Lonneke A. van Vught, Jana Sophia Buhre, Tonći Šuštić, Thijs Luc Junior van Osch, Maurice Steenhuis, Willianne Hoepel, Wenjun Wang, Anne Sophie Lixenfeld, Jan Nouta, Sofie Keijzer, Federica Linty, Remco Visser, Mads Delbo Larsen, Emily Lara Martin, Inga Künsting, Selina Lehrian, Vera von Kopylow, Carsten Kern, Hanna Bele Lunding, Menno de Winther, Niels van Mourik, Theo Rispens, Tobias Graf, Marleen Adriana Slim, René Peter Minnaar, Marije Kristianne Bomers, Jonne Jochum Sikkens, Alexander P.J. Vlaar, C. Ellen van der Schoot, Jeroen den Dunnen, Manfred Wuhrer, Marc Ehlers, Gestur Vidarsson, Spinello Antinori, Cinzia Bassoli, Giovanna Bestetti, Mario Corbellino, Alice Covizzi, Angelica Lupo, Laura Milazzo, Marco Schiuma, Alessandro Torre, Brent Appelman, Diederik Beek van de, Marije K. Bomers, Justin Brabander de, Matthijs C. Brouwer, David T.P. Buis, Nora Chekrouni, Marit J. Gils van, Menno D. Jong de, Ayesha H.A. Lavell, Niels Mourik van, Sabine E. Olie, Edgar J.G. Peters, Tom D.Y. Reijnders, Michiel Schinkel, Alex R. Schuurman, Jonne J. Sikkens, Marleen A. Slim, Yvo M. Smulders, Lonneke A. Vught van, Joost W. Wiersinga
Publikováno v:
EBioMedicine, Vol 87, Iss , Pp 104408- (2023)
Summary: Background: Afucosylated IgG1 responses have only been found against membrane-embedded epitopes, including anti-S in SARS-CoV-2 infections. These responses, intrinsically protective through enhanced FcγRIIIa binding, can also trigger exacer
Externí odkaz:
https://doaj.org/article/bd40a551975d4a2c9340f940154e729f
Autor:
Iwona Wojcik, David E. Schmidt, Lisa A. de Neef, Minke A. E. Rab, Bob Meek, Okke de Weerdt, Manfred Wuhrer, C. Ellen van der Schoot, Jaap J. Zwaginga, Masja de Haas, David Falck, Gestur Vidarsson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract As a lymphoid organ, the spleen hosts a wide range of immune cell populations, which not only remove blood-borne antigens, but also generate and regulate antigen-specific immune responses. In particular, the splenic microenvironment has been
Externí odkaz:
https://doaj.org/article/be3e529ee6ca40edb4e9c9d2fe655c33
Autor:
Mads Delbo Larsen, Mary Lopez-Perez, Emmanuel Kakra Dickson, Paulina Ampomah, Nicaise Tuikue Ndam, Jan Nouta, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Benjamin Mordmüller, Ali Salanti, Morten Agertoug Nielsen, Achille Massougbodji, C. Ellen van der Schoot, Michael F. Ofori, Manfred Wuhrer, Lars Hviid, Gestur Vidarsson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Here, Larsen et al. describe differences in Fc fucosylation of P. falciparum PfEMP1-specific IgG produced in response to natural infection versus VAR2CSA-type subunit vaccination, which leads to differences in the ability to induce FcγRIIIa-dependen
Externí odkaz:
https://doaj.org/article/a9888fc047054d7cb375efcf290854a4
Autor:
Jesse Eernstman, Barbera Veldhuisen, Peter Ligthart, Marieke von Lindern, C. Ellen van der Schoot, Emile van den Akker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Beta-hemoglobinopathies become prominent after birth due to a switch from γ-globin to the mutated β-globin. Haploinsufficiency for the erythroid specific indispensable transcription factor Krueppel-like factor 1 (KLF1) is associated with h
Externí odkaz:
https://doaj.org/article/9ee3cf0d7bf745ada041de96f847e1a5
Autor:
Tonći Šuštić, Julie Van Coillie, Mads Delbo Larsen, Ninotska I.L. Derksen, Zoltan Szittner, Jan Nouta, Wenjun Wang, Timon Damelang, Ianthe Rebergen, Federica Linty, Remco Visser, Juk Yee Mok, Dionne M. Geerdes, Wim J.E. van Esch, Steven W. de Taeye, Marit J. van Gils, Leo van de Watering, C. Ellen van der Schoot, Manfred Wuhrer, Theo Rispens, Gestur Vidarsson
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104109- (2022)
Summary: Background: Immunoglobulin G (IgG) antibodies serve a crucial immuno-protective function mediated by IgG Fc receptors (FcγR). Absence of fucose on the highly conserved N-linked glycan in the IgG Fc domain strongly enhances IgG binding and a
Externí odkaz:
https://doaj.org/article/da752767a6eb419586c7246f663844e9