Zobrazeno 1 - 10
of 265
pro vyhledávání: '"C Edward, Dixon"'
Autor:
Sarah E. Svirsky, Jeremy Henchir, Madison Parry, Erik Holets, Ting Zhang, George K. Gittes, Shaun W. Carlson, C. Edward Dixon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Reductions of neurogranin (Ng), a calcium-sensitive calmodulin-binding protein, result in significant impairment across various hippocampal-dependent learning and memory tasks. Conversely, increasing levels of Ng facilitates synaptic plastic
Externí odkaz:
https://doaj.org/article/af035727d13b423294d6fc156cba879f
Autor:
Sarah E. Svirsky, Youming Li, Jeremy Henchir, Anna Rodina, Shaun W. Carlson, Gabriela Chiosis, C. Edward Dixon
Publikováno v:
Neurobiology of Disease, Vol 188, Iss , Pp 106331- (2023)
Under normal conditions, heat shock proteins work in unison through dynamic protein interactions collectively referred to as the “chaperome.” Recent work revealed that during cellular stress, the functional interactions of the chaperome are modif
Externí odkaz:
https://doaj.org/article/6d24c9ac2c494c03aaf12b6a97227875
Autor:
Jessica Cummings, Yijen L. Wu, C. Edward Dixon, Jeremy Henchir, J. Marc Simard, Ashok Panigrahy, Patrick M. Kochanek, Ruchira M. Jha, Rajesh K. Aneja
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-11 (2023)
Abstract Sepsis-associated brain injury (SABI) is characterized by an acute deterioration of mental status resulting in cognitive impairment and acquisition of new and persistent functional limitations in sepsis survivors. Previously, we reported tha
Externí odkaz:
https://doaj.org/article/09fef268cec240d990a9cc47f2ca7af1
Autor:
Shanshan Song, Md Nabiul Hasan, Lauren Yu, Satya S. Paruchuri, John P. Bielanin, Shamseldin Metwally, Helena C. M. Oft, Sydney G. Fischer, Victoria M. Fiesler, Tanusree Sen, Rajaneesh K. Gupta, Lesley M. Foley, T. Kevin Hitchens, C. Edward Dixon, Franca Cambi, Nilkantha Sen, Dandan Sun
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Differential microglial inflammatory responses play a role in regulation of differentiation and maturation of oligodendrocytes (OLs) in brain white matter. How microglia–OL crosstalk is altered by traumatic brain injury (TBI) and its impac
Externí odkaz:
https://doaj.org/article/9a5a38ebd5124d2ba4abf05f52c62bee
Autor:
Dennis W. Simon, Itay Raphael, Kendall M. Johnson, C. Edward Dixon, Vincent Vagni, Keri Janesko-Feldman, Patrick M. Kochanek, H?lya Bayir, Robert S.B. Clark, Mandy J. McGeachy
Publikováno v:
Neurotrauma Reports, Vol 3, Iss 1, Pp 340-351 (2022)
Interleukin-17 (IL-17) is a proinflammatory cytokine primarily secreted in the brain by inflammatory T lymphocytes and glial cells. IL-17+ T-helper (Th17) cells are increased in the ipsilateral hemisphere after experimental traumatic brain injury (TB
Externí odkaz:
https://doaj.org/article/9df196680da748bd88313faa71ecf773
Autor:
Yongfang Zhao, Hongfeng Mu, Yichen Huang, Sicheng Li, Yangfan Wang, R. Anne Stetler, Michael V. L. Bennett, C. Edward Dixon, Jun Chen, Yejie Shi
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Histone deacetylases (HDACs) are believed to exacerbate traumatic brain injury (TBI) based on studies using pan-HDAC inhibitors. However, the HDAC isoform responsible for the detrimental effects and the cell types involved remain
Externí odkaz:
https://doaj.org/article/6dc79d3778b8478b96d6b51557a3c3f6
Autor:
Hongjian Pu, Yangfan Wang, Tuo Yang, Rehana K. Leak, R. Anne Stetler, Fang Yu, Wenting Zhang, Yejie Shi, Xiaoming Hu, Ke-jie Yin, T. Kevin Hitchens, C. Edward Dixon, Michael V.L. Bennett, Jun Chen
Publikováno v:
Neurobiology of Disease, Vol 180, Iss , Pp 106078- (2023)
Traumatic brain injury (TBI) is commonly followed by intractable psychiatric disorders and long-term changes in affect, such as anxiety. The present study sought to investigate the effect of repetitive intranasal delivery of interleukin-4 (IL-4) nano
Externí odkaz:
https://doaj.org/article/2cc010faead44f79a9f7f797f81fd883
Autor:
Ricky Whitener, Jeremy J. Henchir, Thomas A. Miller, Emily Levy, Aubrienne Krysiewicz-Bell, Eliza S. LaRovere Abrams, Shaun W. Carlson, Naresh Menon, C. Edward Dixon, Michael J. Whalen, Claude J. Rogers
Publikováno v:
Neurotrauma Reports, Vol 3, Iss 1, Pp 158-167 (2022)
Severe traumatic brain injury (TBI), such as that suffered by patients with cerebral contusion, is a major cause of death and disability in young persons. Effective therapeutics to treat or mitigate the effects of severe TBI are lacking, in part beca
Externí odkaz:
https://doaj.org/article/34d7cea5ed5541d494f13ceecb9da5a1
Autor:
Katherine M. Fronczak, Andrea Roberts, Sarah Svirsky, Madison Parry, Erik Holets, Jeremy Henchir, C. Edward Dixon, Shaun W. Carlson
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Repetitive mild traumatic brain injury (rmTBI) is a prominent public health concern, with linkage to debilitating chronic sequelae. Developing reliable and well-characterized preclinical models of rmTBI is imperative in the investigation of the under
Externí odkaz:
https://doaj.org/article/1f6ea21678784a44a20bd54a3b178dd0
Autor:
Joshua A. Beitchman, Jonathan Lifshitz, Neil G. Harris, Theresa Currier Thomas, Audrey D. Lafrenaye, Anders H?nell, C. Edward Dixon, John T. Povlishock, Rachel K. Rowe
Publikováno v:
Neurotrauma Reports, Vol 2, Iss 1, Pp 59-75 (2021)
Diffuse brain injury is better described as multi-focal, where pathology can be found adjacent to seemingly uninjured neural tissue. In experimental diffuse brain injury, pathology and pathophysiology have been reported far more lateral than predicte
Externí odkaz:
https://doaj.org/article/b9f9ed6700cf489bbb06c76cf6e5aa6f